hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11026.1
Complex Portal: CPX-25109
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLF13 | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | 5 | UniProt NCBI |
| PRMT8 | Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4) | 5 | UniProt NCBI |
| RBM3 | RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL) | 5 | UniProt NCBI |
| ANGEL2 | Protein angel homolog 2 | 3 | UniProt NCBI |
| SYNCRIP | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | 5 | UniProt NCBI |
| KHDRBS3 | KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein) | 5 | UniProt NCBI |
| LSM14A | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | 5 | UniProt NCBI |
| PRMT1 | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) | 5 | UniProt NCBI |
| CIRBP | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | 5 | UniProt NCBI |
| NAA40 | N-alpha-acetyltransferase 40 (EC 2.3.1.257) (N-acetyltransferase 11) (N-alpha-acetyltransferase D) (NatD) (hNatD) (Protein acetyltransferase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4947 | 0.00272734094269 | 0.2 | PRMT8 PRMT1 | Nitric oxide metabolism in cystic fibrosis |
| GO:0010608 | 0.00359561840605 | 0.6 | RBM3 CIRBP SYNCRIP LSM14A ANGEL2 PRMT1 | post-transcriptional regulation of gene expression |
| GO:1903311 | 0.0132195963345 | 0.5 | RBM3 KHDRBS3 SYNCRIP CIRBP ANGEL2 | regulation of mRNA metabolic process |
| GO:0006417 | 0.0229192951885 | 0.5 | PRMT1 RBM3 SYNCRIP CIRBP LSM14A | regulation of translation |
| GO:0003729 | 0.0265327626105 | 0.5 | LSM14A ANGEL2 SYNCRIP CIRBP KHDRBS3 | mRNA binding |
| GO:0045727 | 0.0296958080835 | 0.4 | RBM3 SYNCRIP CIRBP PRMT1 | positive regulation of translation |
| CORUM:1731 | 0.0499436884912 | 0.1 | PRMT1 | PRMT1 complex |
| CORUM:2765 | 0.0499436884912 | 0.1 | PRMT1 | PRMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRMT1 | PRMT8 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRMT8 | ANGEL2 | 0.998 |
mutually_exclusive (Q99873)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRMT1 | CIRBP | 0.998 |
mutually_exclusive (Q5VTE6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| PRMT8 | CIRBP | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RBM3 | PRMT8 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LSM14A | PRMT8 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RBM3 | PRMT1 | 0.993 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PRMT8 | SYNCRIP | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLF13 | RBM3 | 0.986 | 0.048 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| LSM14A | PRMT1 | 0.981 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | ||
| NAA40 | ANGEL2 | 0.98 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SYNCRIP | ANGEL2 | 0.976 | 0.1045 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PRMT1 | SYNCRIP | 0.972 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | ||
| KHDRBS3 | SYNCRIP | 0.969 | 0.108 | bioplex_WMM Guru bioplex3_WMM youn_WMM fraction treiber_WMM | |
| PRMT1 | ANGEL2 | 0.958 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| LSM14A | KHDRBS3 | 0.704 | 0.09 | bioplex3_WMM youn_WMM WMM_only | |
| CIRBP | ANGEL2 | 0.665 | 0.058 |
mutually_exclusive (Q99873)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RBM3 | CIRBP | 0.632 | 0.06 |
mutually_exclusive (Q99873)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM treiber_WMM |
| RBM3 | SYNCRIP | 0.295 | 0.214 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| LSM14A | CIRBP | 0.259 | 0.028 | bioplex_WMM bioplex3_WMM gupta_WMM fraction | |
| RBM3 | ANGEL2 | 0.251 | 0.08 |
mutually_exclusive (Q99873)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KLF13 | PRMT1 | 0.192 | hein_WMM WMM_only | ||
| RBM3 | KHDRBS3 | 0.104 | 0.042 | bioplex3_WMM youn_WMM WMM_only | |
| LSM14A | SYNCRIP | 0.087 | 0.138 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| LSM14A | ANGEL2 | 0.086 | 0.086 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CIRBP | SYNCRIP | 0.082 | 0.016 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| PRMT1 | NAA40 | 0.06 |
mutually_exclusive (Q5VTE6)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KLF13 | LSM14A | 0.041 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| KHDRBS3 | ANGEL2 | 0.032 | 0.096 | bioplex3_WMM youn_WMM WMM_only | |
| PRMT1 | KHDRBS3 | 0.029 | bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| KLF13 | CIRBP | 0.018 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBM3 | LSM14A | 0.015 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CIRBP | NAA40 | 0.009 | 0.124 |
mutually_exclusive (Q5VTE6)
|
bioplex3_HEK293 bioplex () bioplex3_HCT116 |
| SYNCRIP | NAA40 | 0.006 | 0.54 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CIRBP | KHDRBS3 | 0.003 | 0.1 | bioplex3_WMM WMM_only | |
| RBM3 | NAA40 | 0.002 | 0.126 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes