hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11033.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | 5 | UniProt NCBI |
| RLBP1 | Retinaldehyde-binding protein 1 (Cellular retinaldehyde-binding protein) | 5 | UniProt NCBI |
| RTL10 | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | 5 | UniProt NCBI |
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | 5 | UniProt NCBI |
| INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | 5 | UniProt NCBI |
| RRM1 | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | 5 | UniProt NCBI |
| FBXO48 | F-box only protein 48 (F-box protein 48) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 7.8760465306e-07 | 0.5 | RRM1 RRM2 RRM2B | Biomarkers for pyrimidine metabolism disorders |
| GO:0005971 | 1.92240082153e-06 | 0.5 | RRM1 RRM2 RRM2B | ribonucleoside-diphosphate reductase complex |
| GO:0061731 | 1.92240082153e-06 | 0.5 | RRM1 RRM2 RRM2B | ribonucleoside-diphosphate reductase activity |
| GO:0004748 | 1.92240082153e-06 | 0.5 | RRM1 RRM2 RRM2B | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| WP:WP4225 | 2.24542123067e-06 | 0.5 | RRM1 RRM2 RRM2B | Pyrimidine metabolism and related diseases |
| REAC:R-HSA-499943 | 1.24783008572e-05 | 0.5 | RRM1 RRM2 RRM2B | Interconversion of nucleotide di- and triphosphates |
| GO:0016728 | 1.92180881975e-05 | 0.5 | RRM1 RRM2 RRM2B | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| KEGG:00240 | 2.80567734252e-05 | 0.5 | RRM1 RRM2 RRM2B | Pyrimidine metabolism |
| KEGG:00480 | 3.87236556688e-05 | 0.5 | RRM1 RRM2 RRM2B | Glutathione metabolism |
| KEGG:00983 | 9.43976951613e-05 | 0.5 | RRM1 RRM2 RRM2B | Drug metabolism - other enzymes |
| GO:0009263 | 0.00010757157937 | 0.5 | RRM1 RRM2 RRM2B | deoxyribonucleotide biosynthetic process |
| GO:0009265 | 0.00010757157937 | 0.5 | RRM1 RRM2 RRM2B | 2'-deoxyribonucleotide biosynthetic process |
| GO:0046385 | 0.00010757157937 | 0.5 | RRM1 RRM2 RRM2B | deoxyribose phosphate biosynthetic process |
| KEGG:01232 | 0.000107816224659 | 0.5 | RRM1 RRM2 RRM2B | Nucleotide metabolism |
| GO:0016725 | 0.0002304395259 | 0.5 | RRM1 RRM2 RRM2B | oxidoreductase activity, acting on CH or CH2 groups |
| KEGG:00230 | 0.000298275635298 | 0.5 | RRM1 RRM2 RRM2B | Purine metabolism |
| REAC:R-HSA-15869 | 0.000511131050826 | 0.5 | RRM1 RRM2 RRM2B | Metabolism of nucleotides |
| WP:WP1601 | 0.00407076266464 | 0.333333333333 | RRM2 RRM1 | Fluoropyrimidine activity |
| GO:0019692 | 0.00440656064028 | 0.5 | RRM1 RRM2 RRM2B | deoxyribose phosphate metabolic process |
| GO:0009394 | 0.00440656064028 | 0.5 | RRM1 RRM2 RRM2B | 2'-deoxyribonucleotide metabolic process |
| GO:0009262 | 0.00498056162807 | 0.5 | RRM1 RRM2 RRM2B | deoxyribonucleotide metabolic process |
| KEGG:04115 | 0.0144916673313 | 0.333333333333 | RRM2 RRM2B | p53 signaling pathway |
| WP:WP2446 | 0.0362670507824 | 0.333333333333 | RRM2 RRM1 | Retinoblastoma gene in cancer |
| KEGG:01100 | 0.0414134615413 | 0.666666666667 | RRM1 INPPL1 RRM2 RRM2B | Metabolic pathways |
| GO:0070318 | 0.042122686785 | 0.333333333333 | RRM2B RRM1 | positive regulation of G0 to G1 transition |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RRM2B | RRM2 | 1.0 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| INPPL1 | RRM2B | 0.986 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RRM2B | RRM1 | 0.979 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| INPPL1 | RLBP1 | 0.979 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| INPPL1 | RRM2 | 0.974 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| RRM1 | FBXO48 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RRM2 | RRM1 | 0.97 | 0.318 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| INPPL1 | RTL10 | 0.958 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRM2B | FBXO48 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| RRM2 | FBXO48 | 0.32 | bioplex_WMM bioplex3_WMM WMM_only | |
| RTL10 | RRM1 | 0.034 | bioplex3_HCT116 WMM_only | |
| INPPL1 | RRM1 | 0.014 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| RLBP1 | RRM2 | 0.008 | gupta_WMM WMM_only |
Related Complexes