hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11034.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
HNRNPH1	Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]	5	UniProt NCBI
NAGK	N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60)	5	UniProt NCBI
TARDBP	TAR DNA-binding protein 43 (TDP-43)	5	UniProt NCBI
HNRNPH2	Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]	5	UniProt NCBI
HNRNPF	Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HPA:0461422	9.14717843682e-06	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; eccrine glands[>=Medium]
CORUM:1287	1.36501667663e-05	0.4	HNRNPH1 HNRNPF	HNRPF-HNRPH1 complex
HPA:0461421	2.65282187994e-05	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; eccrine glands[>=Low]
CORUM:1288	4.09448956317e-05	0.4	HNRNPH1 HNRNPF	DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF)
WP:WP3584	4.10805385987e-05	0.6	HNRNPH1 HNRNPF TARDBP	MECP2 and associated Rett syndrome
HPA:0461423	0.000169328102063	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; eccrine glands[High]
HPA:0471473	0.000319219006781	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; lymphocytes[High]
HPA:0471443	0.000340359638059	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; fibrohistiocytic cells[High]
HPA:0471493	0.000498798374019	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; vascular mural cells[High]
HPA:0461493	0.00060300411182	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; vascular mural cells[High]
HPA:0470182	0.000683901796962	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; cells in granular layer[>=Medium]
HPA:0461472	0.000805816638304	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; lymphocytes[>=Medium]
HPA:0471472	0.00126973557024	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; lymphocytes[>=Medium]
HPA:0471462	0.00138937640585	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; langerhans cells[>=Medium]
HPA:0570762	0.0014268142167	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	testis; pachytene spermatocytes[>=Medium]
HPA:0471412	0.00154572452116	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; cells in spinous layer[>=Medium]
HPA:0570802	0.00158356482678	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	testis; sertoli cells[>=Medium]
HPA:0570783	0.00159410664141	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	testis; preleptotene spermatocytes[High]
HPA:0461492	0.00161900343633	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; vascular mural cells[>=Medium]
HPA:0471492	0.00167292187702	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; vascular mural cells[>=Medium]
HPA:0461442	0.00170451251374	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; fibrohistiocytic cells[>=Medium]
HPA:0470181	0.00183134834989	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; cells in granular layer[>=Low]
HPA:0461471	0.0018531522342	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; lymphocytes[>=Low]
HPA:0100123	0.00190850802923	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	cerebral cortex; glial cells[High]
HPA:0461413	0.00208397740023	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; cells in spinous layer[High]
HPA:0470671	0.00209394959887	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; melanocytes[>=Low]
HPA:0461463	0.00241521762684	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; langerhans cells[High]
HPA:0461411	0.00251845971887	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; cells in spinous layer[>=Low]
CORUM:1332	0.00258714793858	0.4	HNRNPH1 TARDBP	Large Drosha complex
HPA:0351183	0.00268766618047	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	pancreas; pancreatic endocrine cells[High]
HPA:0471461	0.00277537397964	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; langerhans cells[>=Low]
HPA:0471471	0.0029883012645	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; lymphocytes[>=Low]
HPA:0130203	0.00313145510122	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	colon; endothelial cells[High]
HPA:0270353	0.00316394788145	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	kidney; cells in glomeruli[High]
HPA:0471491	0.00326258955925	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; vascular mural cells[>=Low]
HPA:0130243	0.00331328078749	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	colon; peripheral nerve/ganglion[High]
HPA:0440343	0.00334716570579	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	skeletal muscle; myocytes[High]
HPA:0460183	0.00334812702156	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; cells in granular layer[High]
HPA:0471442	0.00338130785257	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; fibrohistiocytic cells[>=Medium]
HPA:0461491	0.00339144619884	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; vascular mural cells[>=Low]
HPA:0471413	0.00356842784326	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; cells in spinous layer[High]
REAC:R-HSA-72163	0.00407681863898	0.6	HNRNPH1 HNRNPH2 HNRNPF	mRNA Splicing - Major Pathway
HPA:0471411	0.00412014949722	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; cells in spinous layer[>=Low]
REAC:R-HSA-6803529	0.00418294558639	0.4	HNRNPH1 HNRNPF	FGFR2 alternative splicing
HPA:0570761	0.00418957947782	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	testis; pachytene spermatocytes[>=Low]
HPA:0471463	0.00433732325393	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; langerhans cells[High]
HPA:0461441	0.00434283939871	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 1; fibrohistiocytic cells[>=Low]
HPA:0470201	0.00438427065649	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; endothelial cells[>=Low]
REAC:R-HSA-72172	0.00451677062682	0.6	HNRNPH1 HNRNPH2 HNRNPF	mRNA Splicing
HPA:0471391	0.00616172683602	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; cells in basal layer[>=Low]
HPA:0460673	0.00635127551111	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	skin 1; melanocytes[High]
HPA:0570801	0.00711993405789	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	testis; sertoli cells[>=Low]
HPA:0460203	0.00713826887462	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; endothelial cells[High]
HPA:0470203	0.00728144353478	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; endothelial cells[High]
HPA:0471441	0.00754988101369	0.8	HNRNPH1 TARDBP HNRNPH2 NAGK	skin 2; fibrohistiocytic cells[>=Low]
HPA:0630223	0.00758106556162	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	cervix; squamous epithelial cells[High]
HPA:0080133	0.0094855580307	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	caudate; neuronal cells[High]
REAC:R-HSA-72203	0.0102904130445	0.6	HNRNPH1 HNRNPH2 HNRNPF	Processing of Capped Intron-Containing Pre-mRNA
HPA:0470673	0.0108340378335	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 2; melanocytes[High]
HPA:0330223	0.011424797654	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	oral mucosa; squamous epithelial cells[High]
HPA:0500701	0.0131603168214	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	soft tissue 1; peripheral nerve[>=Low]
HPA:0461473	0.0133449870931	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; lymphocytes[High]
HPA:0461443	0.0147897127468	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; fibrohistiocytic cells[High]
HPA:0250133	0.0158409039991	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	hippocampus; neuronal cells[High]
HPA:0500702	0.0197095687405	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	soft tissue 1; peripheral nerve[>=Medium]
HPA:0390053	0.0197730832204	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	prostate; glandular cells[High]
HPA:0170053	0.0200286577533	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	endometrium 2; glandular cells[High]
HPA:0530712	0.0210155383112	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	spleen; cells in red pulp[>=Medium]
HPA:0050053	0.0219554107003	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	breast; glandular cells[High]
HPA:0570782	0.0222315456663	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	testis; preleptotene spermatocytes[>=Medium]
REAC:R-HSA-5654738	0.0224106525753	0.4	HNRNPH1 HNRNPF	Signaling by FGFR2
HPA:0570813	0.0224403274321	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	testis; spermatogonia cells[High]
HPA:0510701	0.0247537704307	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	soft tissue 2; peripheral nerve[>=Low]
HPA:0040083	0.0252885802715	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	bone marrow; hematopoietic cells[High]
REAC:R-HSA-190236	0.0285103583123	0.4	HNRNPH1 HNRNPF	Signaling by FGFR
HPA:0050012	0.0292360362423	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	breast; adipocytes[>=Medium]
HPA:0420053	0.029577214981	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	salivary gland; glandular cells[High]
HPA:0510702	0.0297489037729	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	soft tissue 2; peripheral nerve[>=Medium]
HPA:0310432	0.0308725173414	1.0	HNRNPH1 HNRNPF TARDBP HNRNPH2 NAGK	lymph node; germinal center cells[>=Medium]
HPA:0360053	0.035740890287	0.8	HNRNPH1 HNRNPH2 HNRNPF TARDBP	parathyroid gland; glandular cells[High]
HPA:0460182	0.0372666753661	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; cells in granular layer[>=Medium]
CORUM:1181	0.0395319616948	0.4	HNRNPH1 HNRNPF	C complex spliceosome
HPA:0570803	0.0398511078381	0.6	HNRNPH1 HNRNPH2 TARDBP	testis; sertoli cells[High]
WP:WP411	0.0427057597692	0.4	HNRNPH1 HNRNPH2	mRNA processing
HPA:0461462	0.0444139015161	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; langerhans cells[>=Medium]
HPA:0460202	0.0460879152407	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; endothelial cells[>=Medium]
HPA:0461412	0.0463303695681	0.6	HNRNPH1 HNRNPH2 TARDBP	skin 1; cells in spinous layer[>=Medium]
HPA:0490693	0.0465736551749	0.6	HNRNPH1 HNRNPH2 HNRNPF	smooth muscle; smooth muscle cells[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
HNRNPF	HNRNPH1	0.996	0.93	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM
HNRNPH1	HNRNPH2	0.992	0.626	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
HNRNPF	TARDBP	0.986	0.972	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM
HNRNPF	HNRNPH2	0.986	0.576	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM
NAGK	HNRNPH2	0.979	0.032	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
NAGK	HNRNPH1	0.962	0.034	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TARDBP	HNRNPH2	0.75	0.468	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction treiber_WMM
NAGK	HNRNPF	0.335	0.05403125	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TARDBP	HNRNPH1	0.275	0.96	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
NAGK	TARDBP	0.015	0.048	bioplex_WMM bioplex3_WMM fraction

Related Complexes

Genename	Complexes
HNRNPH1	huMAP3_03345.1 huMAP3_04675.1 huMAP3_06054.1 huMAP3_07055.1 huMAP3_07372.1 huMAP3_11034.1 huMAP3_11082.1 huMAP3_13511.1 huMAP3_14523.1
NAGK	huMAP3_01387.1 huMAP3_04675.1 huMAP3_05122.1 huMAP3_06303.1 huMAP3_06910.1 huMAP3_07792.1 huMAP3_08229.1 huMAP3_11034.1 huMAP3_11082.1 huMAP3_13650.1
TARDBP	huMAP3_02533.1 huMAP3_05727.1 huMAP3_06054.1 huMAP3_07784.1 huMAP3_10082.1 huMAP3_11034.1 huMAP3_13511.1
HNRNPH2	huMAP3_03345.1 huMAP3_06054.1 huMAP3_07055.1 huMAP3_07104.1 huMAP3_07372.1 huMAP3_07784.1 huMAP3_11034.1 huMAP3_11082.1 huMAP3_13511.1 huMAP3_14523.1
HNRNPF	huMAP3_02533.1 huMAP3_05727.1 huMAP3_06054.1 huMAP3_07055.1 huMAP3_07104.1 huMAP3_07784.1 huMAP3_11034.1 huMAP3_13511.1 huMAP3_14523.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11034.1