hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11037.1
Complex Portal: CPX-11274
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NSUN2 | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | 5 | UniProt NCBI |
| SKIC8 | Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)] | 5 | UniProt NCBI |
| EEFSEC | Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) | 5 | UniProt NCBI |
| UTP14C | U3 small nucleolar RNA-associated protein 14 homolog C | 5 | UniProt NCBI |
| PNO1 | RNA-binding protein PNO1 (Partner of NOB1) | 5 | UniProt NCBI |
| MTPAP | Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP) | 5 | UniProt NCBI |
| DECR1 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | 5 | UniProt NCBI |
| ABCF2 | ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2) | 3 | UniProt NCBI |
| RO60 | RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) | 5 | UniProt NCBI |
| SKIC2 | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | 5 | UniProt NCBI |
| CYP20A1 | Cytochrome P450 20A1 (EC 1.14.-.-) | 3 | UniProt NCBI |
| UTP14A | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | 5 | UniProt NCBI |
| SKIC3 | Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin) | 5 | UniProt NCBI |
| RPS27L | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1168 | 3.08880131998e-08 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | SKI complex |
| REAC:R-HSA-8953854 | 6.30981065027e-06 | 0.615384615385 | PNO1 SKIC2 SKIC3 UTP14C UTP14A SKIC8 RPS27L NSUN2 | Metabolism of RNA |
| GO:0070478 | 2.74903317479e-05 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| GO:0055087 | 2.74903317479e-05 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | Ski complex |
| REAC:R-HSA-429958 | 8.35637546794e-05 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | mRNA decay by 3' to 5' exoribonuclease |
| KEGG:03018 | 0.00188717471678 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | RNA degradation |
| HP:0025156 | 0.00228133307992 | 0.153846153846 | SKIC2 SKIC3 | Dependency on intravenous nutrition |
| REAC:R-HSA-429914 | 0.0038371560728 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-6791226 | 0.00398594671889 | 0.307692307692 | UTP14C UTP14A RPS27L PNO1 | Major pathway of rRNA processing in the nucleolus and cytosol |
| GO:0034427 | 0.00451731143698 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' |
| REAC:R-HSA-6790901 | 0.00474503209357 | 0.230769230769 | UTP14C UTP14A PNO1 | rRNA modification in the nucleus and cytosol |
| REAC:R-HSA-8868773 | 0.00493256546398 | 0.307692307692 | UTP14C UTP14A RPS27L PNO1 | rRNA processing in the nucleus and cytosol |
| GO:0006414 | 0.00580482931134 | 0.307692307692 | SKIC8 SKIC3 EEFSEC SKIC2 | translational elongation |
| REAC:R-HSA-72312 | 0.00603555238001 | 0.307692307692 | UTP14C UTP14A RPS27L PNO1 | rRNA processing |
| HP:0030056 | 0.0113895015741 | 0.153846153846 | SKIC2 SKIC3 | Uncombable hair |
| HP:0002041 | 0.01593730064 | 0.153846153846 | SKIC2 SKIC3 | Intractable diarrhea |
| GO:0000291 | 0.0310665990836 | 0.230769230769 | SKIC8 SKIC2 SKIC3 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| HP:0009886 | 0.0499631138006 | 0.153846153846 | SKIC2 SKIC3 | Trichorrhexis nodosa |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| SKIC3 | SKIC2 | 0.999 | 0.914 | |
| SKIC3 | SKIC8 | 0.993 | 0.306 | |
| SKIC3 | RO60 | 0.993 | 0.168 | |
| SKIC2 | RO60 | 0.99 | 0.08 | |
| PNO1 | MTPAP | 0.986 | 0.102 | |
| NSUN2 | MTPAP | 0.983 | 0.178 | |
| UTP14A | PNO1 | 0.983 | 0.698 |
structurally_consistent (dimer)
|
| SKIC8 | SKIC2 | 0.981 | 0.426 | |
| EEFSEC | PNO1 | 0.98 | 0.028 | |
| SKIC3 | DECR1 | 0.975 | 0.054 | |
| UTP14C | PNO1 | 0.975 |
structurally_consistent (dimer)
|
|
| SKIC2 | MTPAP | 0.974 | 0.066 | |
| ABCF2 | PNO1 | 0.973 | 0.63 | |
| DECR1 | NSUN2 | 0.972 | 0.056 | |
| SKIC2 | PNO1 | 0.969 | 0.04 | |
| SKIC3 | PNO1 | 0.966 | 0.03 | |
| RPS27L | SKIC2 | 0.964 | 0.09 | |
| CYP20A1 | RO60 | 0.964 | 0.04 | |
| DECR1 | SKIC2 | 0.958 | 0.058 | |
| RO60 | PNO1 | 0.958 | 0.052 | |
| SKIC3 | ABCF2 | 0.956 | 0.066 | |
| SKIC3 | RPS27L | 0.956 | 0.098 | |
| ABCF2 | NSUN2 | 0.955 | 0.174 | |
| SKIC3 | MTPAP | 0.946 | 0.03 | |
| SKIC2 | ABCF2 | 0.934 | 0.106 | |
| PNO1 | NSUN2 | 0.928 | 0.148 | |
| UTP14A | UTP14C | 0.904 |
mutually_exclusive (Q9NRX1)
|
|
| RPS27L | PNO1 | 0.904 | 0.1 | |
| RPS27L | RO60 | 0.891 | 0.172 | |
| DECR1 | MTPAP | 0.885 | 0.024 | |
| SKIC3 | EEFSEC | 0.869 | 0.098 | |
| SKIC3 | NSUN2 | 0.846 | 0.084 | |
| SKIC2 | NSUN2 | 0.842 | 0.09 | |
| ABCF2 | MTPAP | 0.808 | 0.1 | |
| CYP20A1 | PNO1 | 0.664 | 0.01 | |
| RPS27L | MTPAP | 0.661 | 0.074 | |
| SKIC3 | CYP20A1 | 0.63 | 0.03 | |
| DECR1 | PNO1 | 0.583 | 0.012 | |
| RPS27L | NSUN2 | 0.55 | 0.174133333333 | |
| SKIC2 | CYP20A1 | 0.52 | 0.048 | |
| RPS27L | ABCF2 | 0.415 | 0.094 | |
| SKIC2 | EEFSEC | 0.351 | 0.078 | |
| DECR1 | RPS27L | 0.348 | 0.05 | |
| SKIC8 | UTP14A | 0.296 | 0.066 | |
| SKIC8 | MTPAP | 0.239 | 0.056 | |
| RO60 | EEFSEC | 0.192 | 0.106 | |
| CYP20A1 | EEFSEC | 0.192 | 0.082 | |
| DECR1 | ABCF2 | 0.137 | 0.114 | |
| DECR1 | EEFSEC | 0.115 | 0.064 | |
| RPS27L | CYP20A1 | 0.097 | 0.06 | |
| RPS27L | EEFSEC | 0.067 | 0.08 | |
| SKIC8 | RPS27L | 0.056 | 0.164 | |
| UTP14C | NSUN2 | 0.053 | ||
| UTP14A | NSUN2 | 0.053 | 0.258 | |
| RO60 | NSUN2 | 0.05 | 0.114 | |
| DECR1 | RO60 | 0.036 | 0.042 | |
| EEFSEC | NSUN2 | 0.033 | 0.042 | |
| SKIC8 | NSUN2 | 0.029 | 0.188 | |
| RO60 | MTPAP | 0.025 | 0.06 | |
| RO60 | ABCF2 | 0.023 | 0.088 | |
| SKIC8 | RO60 | 0.021 | 0.228 | |
| RO60 | UTP14C | 0.019 | ||
| SKIC8 | ABCF2 | 0.018 | 0.186 | |
| SKIC8 | EEFSEC | 0.018 | 0.118 | |
| ABCF2 | UTP14C | 0.018 | ||
| SKIC8 | UTP14C | 0.014 | ||
| UTP14C | MTPAP | 0.014 | ||
| SKIC8 | PNO1 | 0.012 | 0.098 | |
| DECR1 | SKIC8 | 0.012 | 0.044 | |
| CYP20A1 | ABCF2 | 0.011 | 0.018 | |
| UTP14A | MTPAP | 0.01 | 0.15 | |
| UTP14A | ABCF2 | 0.009 | 0.316 | |
| SKIC8 | CYP20A1 | 0.009 | 0.04 | |
| UTP14A | EEFSEC | 0.006 | 0.012 | |
| SKIC3 | UTP14A | 0.006 | 0.01 | |
| ABCF2 | EEFSEC | 0.005 | 0.044 | |
| DECR1 | UTP14A | 0.003 | 0.016 | |
| RPS27L | UTP14C | 0.002 | ||
| SKIC2 | UTP14A | 0.002 | 0.032 | |
| RO60 | UTP14A | 0.002 | 0.032 | |
| RPS27L | UTP14A | 0.001 | 0.122 |
Related Complexes