hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11037.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
NSUN2	RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)	5	UniProt NCBI
SKIC8	Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]	5	UniProt NCBI
EEFSEC	Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)	5	UniProt NCBI
UTP14C	U3 small nucleolar RNA-associated protein 14 homolog C	5	UniProt NCBI
PNO1	RNA-binding protein PNO1 (Partner of NOB1)	5	UniProt NCBI
MTPAP	Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)	5	UniProt NCBI
DECR1	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)	5	UniProt NCBI
ABCF2	ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2)	3	UniProt NCBI
RO60	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)	5	UniProt NCBI
SKIC2	Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP)	5	UniProt NCBI
CYP20A1	Cytochrome P450 20A1 (EC 1.14.-.-)	3	UniProt NCBI
UTP14A	U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16)	5	UniProt NCBI
SKIC3	Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin)	5	UniProt NCBI
RPS27L	Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1168	3.08880131998e-08	0.230769230769	SKIC8 SKIC2 SKIC3	SKI complex
REAC:R-HSA-8953854	6.30981065027e-06	0.615384615385	NSUN2 UTP14A RPS27L SKIC8 SKIC2 UTP14C SKIC3 PNO1	Metabolism of RNA
GO:0070478	2.74903317479e-05	0.230769230769	SKIC8 SKIC2 SKIC3	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO:0055087	2.74903317479e-05	0.230769230769	SKIC8 SKIC2 SKIC3	Ski complex
REAC:R-HSA-429958	8.35637546794e-05	0.230769230769	SKIC8 SKIC2 SKIC3	mRNA decay by 3' to 5' exoribonuclease
KEGG:03018	0.00188717471678	0.230769230769	SKIC8 SKIC2 SKIC3	RNA degradation
HP:0025156	0.00228133307992	0.153846153846	SKIC3 SKIC2	Dependency on intravenous nutrition
REAC:R-HSA-429914	0.0038371560728	0.230769230769	SKIC8 SKIC2 SKIC3	Deadenylation-dependent mRNA decay
REAC:R-HSA-6791226	0.00398594671889	0.307692307692	UTP14C PNO1 RPS27L UTP14A	Major pathway of rRNA processing in the nucleolus and cytosol
GO:0034427	0.00451731143698	0.230769230769	SKIC8 SKIC2 SKIC3	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
REAC:R-HSA-6790901	0.00474503209357	0.230769230769	UTP14C PNO1 UTP14A	rRNA modification in the nucleus and cytosol
REAC:R-HSA-8868773	0.00493256546398	0.307692307692	UTP14C PNO1 RPS27L UTP14A	rRNA processing in the nucleus and cytosol
GO:0006414	0.00580482931134	0.307692307692	SKIC8 EEFSEC SKIC3 SKIC2	translational elongation
REAC:R-HSA-72312	0.00603555238001	0.307692307692	UTP14C PNO1 RPS27L UTP14A	rRNA processing
HP:0030056	0.0113895015741	0.153846153846	SKIC3 SKIC2	Uncombable hair
HP:0002041	0.01593730064	0.153846153846	SKIC3 SKIC2	Intractable diarrhea
GO:0000291	0.0310665990836	0.230769230769	SKIC8 SKIC2 SKIC3	nuclear-transcribed mRNA catabolic process, exonucleolytic
HP:0009886	0.0499631138006	0.153846153846	SKIC3 SKIC2	Trichorrhexis nodosa

Edges

Protein 1	Protein 2	Score	ProteomeHD
SKIC3	SKIC2	0.999	0.914
SKIC3	SKIC8	0.993	0.306
SKIC3	RO60	0.993	0.168
SKIC2	RO60	0.99	0.08
PNO1	MTPAP	0.986	0.102
NSUN2	MTPAP	0.983	0.178
UTP14A	PNO1	0.983	0.698
SKIC8	SKIC2	0.981	0.426
EEFSEC	PNO1	0.98	0.028
SKIC3	DECR1	0.975	0.054
UTP14C	PNO1	0.975
SKIC2	MTPAP	0.974	0.066
ABCF2	PNO1	0.973	0.63
DECR1	NSUN2	0.972	0.056
SKIC2	PNO1	0.969	0.04
SKIC3	PNO1	0.966	0.03
RPS27L	SKIC2	0.964	0.09
CYP20A1	RO60	0.964	0.04
DECR1	SKIC2	0.958	0.058
RO60	PNO1	0.958	0.052
SKIC3	ABCF2	0.956	0.066
SKIC3	RPS27L	0.956	0.098
ABCF2	NSUN2	0.955	0.174
SKIC3	MTPAP	0.946	0.03
SKIC2	ABCF2	0.934	0.106
PNO1	NSUN2	0.928	0.148
UTP14A	UTP14C	0.904
RPS27L	PNO1	0.904	0.1
RPS27L	RO60	0.891	0.172
DECR1	MTPAP	0.885	0.024
SKIC3	EEFSEC	0.869	0.098
SKIC3	NSUN2	0.846	0.084
SKIC2	NSUN2	0.842	0.09
ABCF2	MTPAP	0.808	0.1
CYP20A1	PNO1	0.664	0.01
RPS27L	MTPAP	0.661	0.074
SKIC3	CYP20A1	0.63	0.03
DECR1	PNO1	0.583	0.012
RPS27L	NSUN2	0.55	0.174133333333
SKIC2	CYP20A1	0.52	0.048
RPS27L	ABCF2	0.415	0.094
SKIC2	EEFSEC	0.351	0.078
DECR1	RPS27L	0.348	0.05
SKIC8	UTP14A	0.296	0.066
SKIC8	MTPAP	0.239	0.056
CYP20A1	EEFSEC	0.192	0.082
RO60	EEFSEC	0.192	0.106
DECR1	ABCF2	0.137	0.114
DECR1	EEFSEC	0.115	0.064
RPS27L	CYP20A1	0.097	0.06
RPS27L	EEFSEC	0.067	0.08
SKIC8	RPS27L	0.056	0.164
UTP14C	NSUN2	0.053
UTP14A	NSUN2	0.053	0.258
RO60	NSUN2	0.05	0.114
DECR1	RO60	0.036	0.042
EEFSEC	NSUN2	0.033	0.042
SKIC8	NSUN2	0.029	0.188
RO60	MTPAP	0.025	0.06
RO60	ABCF2	0.023	0.088
SKIC8	RO60	0.021	0.228
RO60	UTP14C	0.019
SKIC8	ABCF2	0.018	0.186
SKIC8	EEFSEC	0.018	0.118
ABCF2	UTP14C	0.018
SKIC8	UTP14C	0.014
UTP14C	MTPAP	0.014
SKIC8	PNO1	0.012	0.098
DECR1	SKIC8	0.012	0.044
CYP20A1	ABCF2	0.011	0.018
UTP14A	MTPAP	0.01	0.15
UTP14A	ABCF2	0.009	0.316
SKIC8	CYP20A1	0.009	0.04
UTP14A	EEFSEC	0.006	0.012
SKIC3	UTP14A	0.006	0.01
ABCF2	EEFSEC	0.005	0.044
DECR1	UTP14A	0.003	0.016
RPS27L	UTP14C	0.002
SKIC2	UTP14A	0.002	0.032
RO60	UTP14A	0.002	0.032
RPS27L	UTP14A	0.001	0.122

Related Complexes

Genename	Complexes
NSUN2	huMAP3_11037.1 huMAP3_12301.1 huMAP3_12727.1
SKIC8	huMAP3_01232.1 huMAP3_01529.1 huMAP3_02343.1 huMAP3_03766.1 huMAP3_06456.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_09843.1 huMAP3_10359.1 huMAP3_11018.1 huMAP3_11037.1 huMAP3_11092.1 huMAP3_12111.1
EEFSEC	huMAP3_05053.1 huMAP3_08023.1 huMAP3_08373.1 huMAP3_09056.1 huMAP3_11037.1 huMAP3_11115.1 huMAP3_12301.1 huMAP3_12727.1
UTP14C	huMAP3_05053.1 huMAP3_05134.1 huMAP3_08152.1 huMAP3_09056.1 huMAP3_11037.1 huMAP3_12301.1 huMAP3_12727.1 huMAP3_13023.1
PNO1	huMAP3_05053.1 huMAP3_05134.1 huMAP3_08152.1 huMAP3_08239.1 huMAP3_09056.1 huMAP3_11037.1 huMAP3_12301.1 huMAP3_12727.1
MTPAP	huMAP3_11037.1 huMAP3_12301.1
DECR1	huMAP3_00934.1 huMAP3_01535.1 huMAP3_06383.1 huMAP3_07770.1 huMAP3_09415.1 huMAP3_10599.1 huMAP3_11037.1 huMAP3_11731.1 huMAP3_12301.1 huMAP3_12727.1 huMAP3_13926.1
ABCF2	huMAP3_04277.1 huMAP3_06981.1 huMAP3_08152.1 huMAP3_09056.1 huMAP3_11037.1 huMAP3_11129.1 huMAP3_12301.1
RO60	huMAP3_01643.1 huMAP3_05421.1 huMAP3_06958.1 huMAP3_06970.1 huMAP3_07756.1 huMAP3_09371.1 huMAP3_11037.1 huMAP3_11084.1
SKIC2	huMAP3_01535.1 huMAP3_06383.1 huMAP3_06958.1 huMAP3_07717.1 huMAP3_09415.1 huMAP3_09525.1 huMAP3_11037.1 huMAP3_12301.1 huMAP3_12727.1
CYP20A1	huMAP3_01643.1 huMAP3_05421.1 huMAP3_11037.1 huMAP3_11084.1 huMAP3_11203.1 huMAP3_12276.1 huMAP3_14928.1
UTP14A	huMAP3_02116.1 huMAP3_03535.1 huMAP3_03583.1 huMAP3_05053.1 huMAP3_05134.1 huMAP3_07610.1 huMAP3_08152.1 huMAP3_08239.1 huMAP3_08896.1 huMAP3_09056.1 huMAP3_09196.1 huMAP3_10039.1 huMAP3_10171.1 huMAP3_10761.1 huMAP3_11037.1 huMAP3_13023.1
SKIC3	huMAP3_00703.1 huMAP3_01232.1 huMAP3_02562.1 huMAP3_06383.1 huMAP3_07717.1 huMAP3_09415.1 huMAP3_09525.1 huMAP3_10568.1 huMAP3_11037.1 huMAP3_12301.1 huMAP3_12727.1
RPS27L	huMAP3_01232.1 huMAP3_01409.1 huMAP3_01535.1 huMAP3_02562.1 huMAP3_06383.1 huMAP3_08023.1 huMAP3_09415.1 huMAP3_11037.1 huMAP3_11115.1 huMAP3_12301.1 huMAP3_12727.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11037.1