hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11039.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LPIN2 | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | 5 | UniProt NCBI |
| LPIN3 | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | 5 | UniProt NCBI |
| CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | 5 | UniProt NCBI |
| ZFP36L2 | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | 5 | UniProt NCBI |
| LPIN1 | Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1483213 | 5.14505990951e-07 | 0.6 | LPIN2 LPIN1 LPIN3 | Synthesis of PE |
| REAC:R-HSA-75109 | 6.85937538545e-07 | 0.6 | LPIN2 LPIN1 LPIN3 | Triglyceride biosynthesis |
| WP:WP5275 | 8.19946297372e-07 | 0.6 | LPIN2 LPIN1 LPIN3 | Ether lipid biosynthesis |
| REAC:R-HSA-4419969 | 8.91627220919e-07 | 0.6 | LPIN2 LPIN1 LPIN3 | Depolymerization of the Nuclear Lamina |
| WP:WP5101 | 9.83834482812e-07 | 0.6 | LPIN2 LPIN1 LPIN3 | Congenital generalized lipodystrophy |
| REAC:R-HSA-1483191 | 5.51556094215e-06 | 0.6 | LPIN2 LPIN1 LPIN3 | Synthesis of PC |
| REAC:R-HSA-8979227 | 1.54330255969e-05 | 0.6 | LPIN2 LPIN1 LPIN3 | Triglyceride metabolism |
| KEGG:00561 | 2.17491853578e-05 | 0.6 | LPIN2 LPIN1 LPIN3 | Glycerolipid metabolism |
| REAC:R-HSA-2980766 | 5.03751582702e-05 | 0.6 | LPIN2 LPIN1 LPIN3 | Nuclear Envelope Breakdown |
| KEGG:00564 | 7.3222294744e-05 | 0.6 | LPIN2 LPIN1 LPIN3 | Glycerophospholipid metabolism |
| GO:0008195 | 0.000211268761872 | 0.6 | LPIN2 LPIN1 LPIN3 | phosphatidate phosphatase activity |
| WP:WP236 | 0.00023712659371 | 0.6 | LPIN2 LPIN1 LPIN3 | Adipogenesis |
| KEGG:04936 | 0.00028582601872 | 0.6 | LPIN2 LPIN1 LPIN3 | Alcoholic liver disease |
| KEGG:04150 | 0.000486709886236 | 0.6 | LPIN2 LPIN1 LPIN3 | mTOR signaling pathway |
| GO:0042577 | 0.000537554131189 | 0.6 | LPIN2 LPIN1 LPIN3 | lipid phosphatase activity |
| REAC:R-HSA-1483206 | 0.000578912790256 | 0.6 | LPIN2 LPIN1 LPIN3 | Glycerophospholipid biosynthesis |
| REAC:R-HSA-68875 | 0.000910160054501 | 0.6 | LPIN2 LPIN1 LPIN3 | Mitotic Prophase |
| WP:WP2533 | 0.00205749802636 | 0.4 | LPIN2 LPIN1 | Glycerophospholipid biosynthetic pathway |
| REAC:R-HSA-1483257 | 0.0027382103682 | 0.6 | LPIN2 LPIN1 LPIN3 | Phospholipid metabolism |
| GO:0019432 | 0.00522817157061 | 0.6 | LPIN2 LPIN1 LPIN3 | triglyceride biosynthetic process |
| GO:0046463 | 0.00807957978043 | 0.6 | LPIN2 LPIN1 LPIN3 | acylglycerol biosynthetic process |
| GO:0046460 | 0.00807957978043 | 0.6 | LPIN2 LPIN1 LPIN3 | neutral lipid biosynthetic process |
| REAC:R-HSA-68886 | 0.0287469323532 | 0.6 | LPIN2 LPIN1 LPIN3 | M Phase |
| GO:0006641 | 0.0457443058639 | 0.6 | LPIN2 LPIN1 LPIN3 | triglyceride metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LPIN2 | LPIN3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LPIN3 | LPIN1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| LPIN2 | LPIN1 | 0.991 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LPIN3 | CAMKK1 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ZFP36L2 | LPIN1 | 0.95 | 0.104 | hein_WMM bioplex3_WMM WMM_only boldt_WMM |
| LPIN2 | CAMKK1 | 0.303 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| CAMKK1 | LPIN1 | 0.164 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| LPIN3 | ZFP36L2 | 0.133 | bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes