hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11045.1
Complex Portal: CPX-11282
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ELP4 | Elongator complex protein 4 (hELP4) (PAX6 neighbor gene protein) | 5 | UniProt NCBI |
| ELP5 | Elongator complex protein 5 (Dermal papilla-derived protein 6) (S-phase 2 protein) | 5 | UniProt NCBI |
| LIG1 | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | 5 | UniProt NCBI |
| ELP6 | Elongator complex protein 6 (Angiotonin-transactivated protein 1) (Protein TMEM103) | 5 | UniProt NCBI |
| ZNF639 | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | 5 | UniProt NCBI |
| ZBTB2 | Zinc finger and BTB domain-containing protein 2 | 5 | UniProt NCBI |
| LALBA | Alpha-lactalbumin (Lactose synthase B protein) (Lysozyme-like protein 7) | 5 | UniProt NCBI |
| ZBTB25 | Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) | 5 | UniProt NCBI |
| CSN3 | Kappa-casein | 5 | UniProt NCBI |
| PIPOX | Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6332 | 2.61903437064e-07 | 0.333333333333 | ELP4 ELP5 ELP6 | Elongator complex (ELP1, ELP2, ELP3, ELP4, ELP5, ELP6) |
| GO:0033588 | 0.000161332517231 | 0.333333333333 | ELP4 ELP5 ELP6 | elongator holoenzyme complex |
| HPA:0280383 | 0.000645794308625 | 0.222222222222 | LALBA CSN3 | lactating breast; lactating glandular cells[High] |
| HPA:0280382 | 0.00120471285032 | 0.222222222222 | LALBA CSN3 | lactating breast; lactating glandular cells[>=Medium] |
| HPA:0280000 | 0.00154842184106 | 0.222222222222 | LALBA CSN3 | lactating breast |
| HPA:0280381 | 0.00154842184106 | 0.222222222222 | LALBA CSN3 | lactating breast; lactating glandular cells[>=Low] |
| GO:0002098 | 0.00546674693619 | 0.333333333333 | ELP4 ELP5 ELP6 | tRNA wobble uridine modification |
| GO:0002097 | 0.00915637133828 | 0.333333333333 | ELP4 ELP5 ELP6 | tRNA wobble base modification |
| REAC:R-HSA-3214847 | 0.0128638830436 | 0.333333333333 | ELP4 ELP5 ELP6 | HATs acetylate histones |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZBTB2 | ZNF639 | 1.0 | 0.132 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| ELP5 | ELP6 | 1.0 | 0.386 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| ELP4 | ELP6 | 1.0 | 0.57 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PIPOX | ELP5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LALBA | PIPOX | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZBTB2 | ZBTB25 | 0.998 | 0.068 |
mutually_exclusive (Q8N4J0)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PIPOX | ELP6 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PIPOX | CSN3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ELP4 | ELP5 | 0.996 | 0.438 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ZBTB2 | ELP6 | 0.995 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIPOX | ELP4 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZBTB25 | ELP6 | 0.985 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ZBTB2 | LIG1 | 0.984 | 0.228166666667 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZNF639 | ELP6 | 0.981 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ZBTB25 | ZNF639 | 0.966 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| LALBA | CSN3 | 0.902 | bioplex3_WMM WMM_only | ||
| LALBA | ELP5 | 0.902 | bioplex3_WMM WMM_only | ||
| LALBA | ELP6 | 0.869 | bioplex3_WMM WMM_only | ||
| ZBTB2 | ELP4 | 0.757 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZBTB25 | LIG1 | 0.388 | 0.082 | bioplex3_WMM WMM_only | |
| ZBTB25 | ELP4 | 0.377 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZBTB2 | ELP5 | 0.37 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF639 | LIG1 | 0.356 | 0.088 | bioplex3_WMM WMM_only | |
| CSN3 | ELP6 | 0.227 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| ZBTB25 | ELP5 | 0.224 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| CSN3 | ELP5 | 0.219 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| ZNF639 | ELP5 | 0.215 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF639 | ELP4 | 0.215 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| LALBA | ELP4 | 0.214 | bioplex3_WMM WMM_only | ||
| LIG1 | ELP6 | 0.024 | 0.112 | bioplex3_WMM youn_WMM WMM_only | |
| CSN3 | ELP4 | 0.015 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| LIG1 | ELP5 | 0.008 | 0.114 | youn_WMM WMM_only | |
| LIG1 | ELP4 | 0.003 | 0.094 | youn_WMM WMM_only |
Related Complexes