hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11048.1
Complex Portal: CPX-24632
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PROK2 | Prokineticin-2 (PK2) (Protein Bv8 homolog) | 5 | UniProt NCBI |
| UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 5 | UniProt NCBI |
| LRRC20 | Leucine-rich repeat-containing protein 20 | 2 | UniProt NCBI |
| ACTC1 | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | 5 | UniProt NCBI |
| ACTBL2 | Beta-actin-like protein 2 (Kappa-actin) | 4 | UniProt NCBI |
| ACTA2 | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | 5 | UniProt NCBI |
| PHACTR2 | Phosphatase and actin regulator 2 | 5 | UniProt NCBI |
| CAP2 | Adenylyl cyclase-associated protein 2 (CAP 2) | 5 | UniProt NCBI |
| CAP1 | Adenylyl cyclase-associated protein 1 (CAP 1) | 5 | UniProt NCBI |
| POTEF | POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428890 | 0.00284368219242 | 0.2 | CAP2 CAP1 | Role of ABL in ROBO-SLIT signaling |
| HPA:0640693 | 0.0119003486202 | 0.2 | ACTA2 CAP2 | endometrium; smooth muscle cells[High] |
| WP:WP383 | 0.0243817991122 | 0.2 | ACTC1 ACTA2 | Striated muscle contraction pathway |
| WP:WP4534 | 0.0319043985122 | 0.2 | ACTC1 ACTA2 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| HPA:0640692 | 0.036005271879 | 0.2 | ACTA2 CAP2 | endometrium; smooth muscle cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAP2 | CAP1 | 1.0 | 0.416 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CAP2 | ACTBL2 | 0.999 | 0.084 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CAP1 | ACTBL2 | 0.998 | 0.340111111111 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| ACTA2 | CAP2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ACTA2 | CAP1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| POTEF | ACTBL2 | 0.995 | 0.93 |
mutually_exclusive (P40123)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| CAP2 | UBC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LRRC20 | ACTBL2 | 0.992 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ACTC1 | CAP2 | 0.991 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ACTBL2 | PHACTR2 | 0.983 | 0.311333333333 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACTA2 | ACTBL2 | 0.98 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| ACTA2 | PHACTR2 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LRRC20 | ACTA2 | 0.958 |
structurally_consistent (P60709)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAP2 | POTEF | 0.957 | 0.088 |
mutually_exclusive (Q562R1)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only |
| POTEF | PROK2 | 0.955 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ACTC1 | ACTBL2 | 0.93 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only | ||
| ACTC1 | PHACTR2 | 0.851 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LRRC20 | ACTC1 | 0.735 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CAP1 | UBC | 0.591 | bioplex3_WMM WMM_only boldt_WMM | ||
| ACTA2 | ACTC1 | 0.449 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | ||
| CAP1 | POTEF | 0.41 | 0.342 |
mutually_exclusive (Q562R1)
|
bioplex3_WMM WMM_only |
| ACTC1 | CAP1 | 0.342 |
mutually_exclusive (P40123)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| UBC | POTEF | 0.291 | bioplex3_WMM WMM_only | ||
| CAP1 | PHACTR2 | 0.209 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAP2 | PHACTR2 | 0.202 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACTA2 | POTEF | 0.12 |
mutually_exclusive (P40123)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| UBC | ACTBL2 | 0.102 | bioplex3_WMM WMM_only | ||
| ACTA2 | UBC | 0.099 | bioplex3_WMM boldt boldt_WMM WMM_only | ||
| ACTC1 | POTEF | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ACTC1 | UBC | 0.023 | bioplex3_WMM WMM_only boldt_WMM | ||
| LRRC20 | POTEF | 0.018 | 0.044 | bioplex_WMM WMM_only | |
| ACTC1 | PROK2 | 0.008 | bioplex3_HCT116 WMM_only | ||
| LRRC20 | CAP1 | 0.002 | 0.054 | bioplex3_HCT116 WMM_only |
Related Complexes