hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11061.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNRC6C | Trinucleotide repeat-containing gene 6C protein | 5 | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | 5 | UniProt NCBI |
| TNRC6A | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | 5 | UniProt NCBI |
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | 5 | UniProt NCBI |
| TNRC6B | Trinucleotide repeat-containing gene 6B protein | 5 | UniProt NCBI |
| AGO4 | Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 9.51665903358e-20 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 3.80666361343e-19 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-9768778 | 3.80666361343e-19 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Regulation of NPAS4 mRNA translation |
| REAC:R-HSA-8943723 | 1.14199908403e-18 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Regulation of PTEN mRNA translation |
| REAC:R-HSA-9768759 | 2.85499771007e-18 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Regulation of NPAS4 gene expression |
| REAC:R-HSA-8934593 | 1.68254531714e-16 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9634815 | 5.12186589187e-15 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9022692 | 6.45800482018e-15 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 1.00099074713e-14 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-2559585 | 1.50576385893e-14 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Oncogene Induced Senescence |
| REAC:R-HSA-8853884 | 3.16059666496e-14 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Transcriptional Regulation by VENTX |
| REAC:R-HSA-9024446 | 4.4356100923e-14 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | NR1H2 and NR1H3-mediated signaling |
| GO:0035278 | 4.57652326261e-14 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | miRNA-mediated gene silencing by inhibition of translation |
| REAC:R-HSA-8986944 | 3.12112156329e-13 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 3.12112156329e-13 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Ca2+ pathway |
| REAC:R-HSA-1912408 | 2.97217415752e-12 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5628897 | 3.77896585315e-12 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-8936459 | 4.08536848989e-12 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-5687128 | 4.41219796908e-12 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912422 | 9.69432630241e-12 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Pre-NOTCH Expression and Processing |
| GO:0035195 | 2.25440881952e-11 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | miRNA-mediated post-transcriptional gene silencing |
| REAC:R-HSA-2559580 | 2.45699148207e-11 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Oxidative Stress Induced Senescence |
| REAC:R-HSA-211000 | 4.47982414893e-11 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Gene Silencing by RNA |
| REAC:R-HSA-9018519 | 7.02788877184e-11 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Estrogen-dependent gene expression |
| GO:0035194 | 8.48945065214e-11 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | regulatory ncRNA-mediated post-transcriptional gene silencing |
| REAC:R-HSA-6807070 | 1.0212516238e-10 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | PTEN Regulation |
| REAC:R-HSA-3858494 | 1.06838631413e-10 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Beta-catenin independent WNT signaling |
| GO:0016441 | 1.85131237804e-10 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | post-transcriptional gene silencing |
| REAC:R-HSA-2559583 | 4.97348545126e-10 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Cellular Senescence |
| REAC:R-HSA-8939211 | 6.97456429516e-10 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | ESR-mediated signaling |
| REAC:R-HSA-157118 | 1.26360308449e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Signaling by NOTCH |
| REAC:R-HSA-8878171 | 1.55096825923e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 2.61739309821e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | PIP3 activates AKT signaling |
| GO:0031047 | 3.01089364494e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | regulatory ncRNA-mediated gene silencing |
| REAC:R-HSA-9006931 | 4.03332839379e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Signaling by Nuclear Receptors |
| REAC:R-HSA-5683057 | 4.2353857595e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | MAPK family signaling cascades |
| GO:0017148 | 5.28740914265e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | negative regulation of translation |
| REAC:R-HSA-9006925 | 6.17695829337e-09 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Intracellular signaling by second messengers |
| REAC:R-HSA-195721 | 1.23174824354e-08 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Signaling by WNT |
| GO:0034249 | 1.42122328137e-08 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | negative regulation of amide metabolic process |
| REAC:R-HSA-3700989 | 2.69262180848e-08 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Transcriptional Regulation by TP53 |
| GO:0006402 | 3.33591214305e-07 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | mRNA catabolic process |
| GO:0036464 | 3.75570851491e-07 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | cytoplasmic ribonucleoprotein granule |
| GO:0016442 | 3.94651622678e-07 | 0.666666666667 | AGO1 AGO4 AGO3 TNRC6A | RISC complex |
| GO:0031332 | 3.94651622678e-07 | 0.666666666667 | AGO1 AGO4 AGO3 TNRC6A | RNAi effector complex |
| REAC:R-HSA-426486 | 5.93134254527e-07 | 0.5 | AGO1 AGO3 AGO4 | Small interfering RNA (siRNA) biogenesis |
| GO:0035770 | 6.06439948643e-07 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | ribonucleoprotein granule |
| GO:0006401 | 1.1242652898e-06 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | RNA catabolic process |
| GO:0006417 | 1.75842000413e-06 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | regulation of translation |
| REAC:R-HSA-2262752 | 2.64149968796e-06 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Cellular responses to stress |
| REAC:R-HSA-8953897 | 2.79926993011e-06 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Cellular responses to stimuli |
| GO:0034248 | 4.78282062515e-06 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | regulation of amide metabolic process |
| REAC:R-HSA-203927 | 1.24783008572e-05 | 0.5 | AGO1 AGO3 AGO4 | MicroRNA (miRNA) biogenesis |
| GO:0034655 | 1.76580945595e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | nucleobase-containing compound catabolic process |
| GO:0010608 | 1.87774310691e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | post-transcriptional regulation of gene expression |
| REAC:R-HSA-212436 | 2.1578946509e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Generic Transcription Pathway |
| GO:0046700 | 2.68096414183e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | heterocycle catabolic process |
| GO:0044270 | 2.71981869461e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | cellular nitrogen compound catabolic process |
| GO:0019439 | 2.92120387676e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | aromatic compound catabolic process |
| GO:1901361 | 3.65107454417e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | organic cyclic compound catabolic process |
| REAC:R-HSA-73857 | 4.17740470622e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 8.88513506469e-05 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Gene expression (Transcription) |
| GO:0070578 | 0.00010757157937 | 0.5 | AGO1 AGO3 AGO4 | RISC-loading complex |
| GO:0006412 | 0.000118417549116 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | translation |
| GO:0043043 | 0.000141389276595 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | peptide biosynthetic process |
| GO:0016071 | 0.000144505202752 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | mRNA metabolic process |
| GO:0010501 | 0.000161332517231 | 0.5 | AGO1 AGO3 AGO4 | RNA secondary structure unwinding |
| GO:0051248 | 0.00017155614265 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | negative regulation of protein metabolic process |
| GO:0070922 | 0.0002304395259 | 0.5 | AGO1 AGO3 AGO4 | RISC complex assembly |
| GO:0043604 | 0.000411170968199 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | amide biosynthetic process |
| GO:0060213 | 0.00042234232358 | 0.5 | TNRC6C TNRC6B TNRC6A | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| GO:0006518 | 0.000446172352959 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | peptide metabolic process |
| GO:0060211 | 0.000548960443183 | 0.5 | TNRC6C TNRC6B TNRC6A | regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| GO:0010629 | 0.000826395680207 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | negative regulation of gene expression |
| GO:0031054 | 0.0010743908712 | 0.5 | AGO1 AGO3 AGO4 | pre-miRNA processing |
| REAC:R-HSA-162582 | 0.00128853291586 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | Signal Transduction |
| GO:0099080 | 0.00221939891188 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | supramolecular complex |
| GO:0043603 | 0.00239328344874 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | amide metabolic process |
| GO:0000956 | 0.00242244235372 | 0.666666666667 | AGO1 TNRC6C TNRC6B TNRC6A | nuclear-transcribed mRNA catabolic process |
| GO:0009057 | 0.00674613151229 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | macromolecule catabolic process |
| GO:0000289 | 0.00777254411354 | 0.5 | TNRC6C TNRC6B TNRC6A | nuclear-transcribed mRNA poly(A) tail shortening |
| GO:0035198 | 0.00860399003151 | 0.5 | AGO1 AGO3 AGO4 | miRNA binding |
| GO:1902555 | 0.00860399003151 | 0.5 | AGO1 AGO3 AGO4 | endoribonuclease complex |
| GO:1905348 | 0.0125202207278 | 0.5 | AGO1 AGO3 AGO4 | endonuclease complex |
| GO:0044248 | 0.0138295426169 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | cellular catabolic process |
| GO:0035196 | 0.0161301339283 | 0.5 | AGO1 AGO3 AGO4 | miRNA processing |
| GO:0061980 | 0.017471616814 | 0.5 | AGO1 AGO3 AGO4 | regulatory RNA binding |
| GO:1901566 | 0.0225352456866 | 1.0 | AGO4 AGO1 AGO3 TNRC6A TNRC6B TNRC6C | organonitrogen compound biosynthetic process |
| CORUM:1386 | 0.0499436884912 | 0.166666666667 | AGO4 | TTP-AGO4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TNRC6B | TNRC6A | 0.998 | 0.208 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AGO3 | TNRC6A | 0.996 | 0.166 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| TNRC6B | AGO3 | 0.993 | 0.152 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| TNRC6A | AGO1 | 0.991 | 0.164456790123 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| TNRC6B | AGO1 | 0.991 | 0.108 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| AGO3 | AGO1 | 0.99 | 0.288 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| TNRC6C | AGO1 | 0.969 | 0.242171075838 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction |
| AGO3 | AGO4 | 0.968 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| AGO4 | AGO1 | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| TNRC6C | TNRC6A | 0.902 | 0.104 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AGO4 | TNRC6A | 0.715 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TNRC6C | AGO4 | 0.594 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TNRC6B | AGO4 | 0.57 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TNRC6B | TNRC6C | 0.458 | 0.156 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| TNRC6C | AGO3 | 0.239 | 0.08 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes