hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11063.1
Complex Portal: CPX-16678
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TOP2B | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | 5 | UniProt NCBI |
| NOL9 | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | 5 | UniProt NCBI |
| H2AB1 | Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd) | 5 | UniProt NCBI |
| SENP3 | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | 5 | UniProt NCBI |
| APOBEC3A | DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1) | 5 | UniProt NCBI |
| WDR18 | WD repeat-containing protein 18 | 5 | UniProt NCBI |
| LAS1L | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | 5 | UniProt NCBI |
| NAP1L1 | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6855 | 5.03944556454e-11 | 0.5 | LAS1L NOL9 SENP3 WDR18 | LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex |
| CORUM:6854 | 9.81744484776e-08 | 0.375 | WDR18 SENP3 LAS1L | 5FMC (Friends of Methylated Chtop) complex |
| REAC:R-HSA-6791226 | 0.000318925497353 | 0.5 | LAS1L NOL9 SENP3 WDR18 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.000395754397668 | 0.5 | LAS1L NOL9 SENP3 WDR18 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.000485585116423 | 0.5 | LAS1L NOL9 SENP3 WDR18 | rRNA processing |
| REAC:R-HSA-8953854 | 0.00234371756137 | 0.625 | WDR18 NOL9 LAS1L SENP3 APOBEC3A | Metabolism of RNA |
| CORUM:5386 | 0.0077239395488 | 0.25 | SENP3 LAS1L | MLL1-WDR5 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SENP3 | WDR18 | 1.0 | 0.238 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction | |
| NOL9 | WDR18 | 1.0 | 0.94 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM | |
| NOL9 | LAS1L | 1.0 | 0.976 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| WDR18 | LAS1L | 1.0 | 0.86 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM | |
| SENP3 | NOL9 | 1.0 | 0.392 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SENP3 | LAS1L | 0.999 | 0.586 |
mutually_exclusive (Q5SY16)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| APOBEC3A | H2AB1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| H2AB1 | NOL9 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| H2AB1 | LAS1L | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SENP3 | TOP2B | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| H2AB1 | WDR18 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NOL9 | NAP1L1 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | ||
| H2AB1 | SENP3 | 0.969 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SENP3 | NAP1L1 | 0.969 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | ||
| LAS1L | TOP2B | 0.966 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | ||
| LAS1L | NAP1L1 | 0.943 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM | ||
| WDR18 | NAP1L1 | 0.317 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | ||
| NOL9 | TOP2B | 0.173 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | ||
| WDR18 | TOP2B | 0.15 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| APOBEC3A | LAS1L | 0.083 | bioplex3_WMM WMM_only | ||
| APOBEC3A | WDR18 | 0.074 | bioplex3_WMM WMM_only | ||
| H2AB1 | NAP1L1 | 0.069 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| APOBEC3A | NOL9 | 0.042 | bioplex3_WMM WMM_only | ||
| APOBEC3A | SENP3 | 0.027 | bioplex3_WMM WMM_only | ||
| NAP1L1 | TOP2B | 0.009 | bioplex3_WMM gupta_WMM WMM_only boldt_WMM | ||
| APOBEC3A | NAP1L1 | 0.002 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes