hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11071.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS13D | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | 5 | UniProt NCBI |
| TMEM31 | Transmembrane protein 31 | 2 | UniProt NCBI |
| UBQLN4 | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | 5 | UniProt NCBI |
| UBQLN1 | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) | 5 | UniProt NCBI |
| UBQLN2 | Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) | 5 | UniProt NCBI |
| ZRANB1 | Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) | 5 | UniProt NCBI |
| SLC17A2 | Sodium-dependent phosphate transport protein 3 (Na(+)/PI cotransporter 3) (Sodium/phosphate cotransporter 3) (Solute carrier family 17 member 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5209 | 0.000205125012531 | 0.285714285714 | UBQLN2 UBQLN1 | Ubiquilin-proteasome complex |
| GO:0031593 | 0.000288863510592 | 0.571428571429 | UBQLN2 ZRANB1 UBQLN4 UBQLN1 | polyubiquitin modification-dependent protein binding |
| KEGG:04141 | 0.00211181505065 | 0.428571428571 | UBQLN2 UBQLN4 UBQLN1 | Protein processing in endoplasmic reticulum |
| GO:0016241 | 0.011574920454 | 0.571428571429 | UBQLN2 VPS13D UBQLN1 UBQLN4 | regulation of macroautophagy |
| KEGG:05014 | 0.0184567258965 | 0.428571428571 | UBQLN2 UBQLN4 UBQLN1 | Amyotrophic lateral sclerosis |
| GO:0140030 | 0.0218746163137 | 0.571428571429 | UBQLN2 ZRANB1 UBQLN4 UBQLN1 | modification-dependent protein binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TMEM31 | UBQLN2 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM31 | UBQLN1 | 0.98 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM31 | ZRANB1 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TMEM31 | UBQLN4 | 0.97 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM31 | VPS13D | 0.96 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SLC17A2 | UBQLN2 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLC17A2 | UBQLN4 | 0.954 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBQLN1 | SLC17A2 | 0.743 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBQLN1 | UBQLN2 | 0.698 | bioplex_WMM bioplex3_WMM fraction | |
| UBQLN2 | UBQLN4 | 0.661 | 0.788 | bioplex_WMM bioplex3_WMM WMM_only |
| UBQLN1 | UBQLN4 | 0.491 | bioplex_WMM bioplex3_WMM fraction | |
| VPS13D | ZRANB1 | 0.076 | bioplex3_WMM WMM_only | |
| UBQLN1 | ZRANB1 | 0.043 | bioplex3_WMM WMM_only | |
| ZRANB1 | UBQLN4 | 0.04 | bioplex3_WMM WMM_only | |
| ZRANB1 | UBQLN2 | 0.04 | bioplex3_WMM WMM_only | |
| VPS13D | UBQLN2 | 0.034 | 0.03 | bioplex3_WMM WMM_only |
| VPS13D | UBQLN4 | 0.022 | 0.072 | bioplex3_WMM WMM_only |
| VPS13D | UBQLN1 | 0.019 | bioplex3_WMM WMM_only |
Related Complexes