hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11074.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CALD1 | Caldesmon (CDM) | 5 | UniProt NCBI |
| API5 | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) | 5 | UniProt NCBI |
| TJP2 | Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2) | 5 | UniProt NCBI |
| APEX1 | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (REF-1) (Redox factor-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | 5 | UniProt NCBI |
| MAP4 | Microtubule-associated protein 4 (MAP-4) | 5 | UniProt NCBI |
| MYLK | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0640693 | 0.00187254522974 | 0.4 | CALD1 MYLK | endometrium; smooth muscle cells[High] |
| HPA:0460201 | 0.00355592165412 | 0.8 | MAP4 MYLK CALD1 TJP2 | skin 1; endothelial cells[>=Low] |
| HPA:0470201 | 0.00438427065649 | 0.8 | MAP4 MYLK CALD1 TJP2 | skin 2; endothelial cells[>=Low] |
| HPA:0641503 | 0.00568622014719 | 0.4 | CALD1 MYLK | endometrium; ciliated epithelial cells[High] |
| HPA:0641522 | 0.00568622014719 | 0.4 | CALD1 MYLK | endometrium; nonciliated luminal epithelial cells[>=Medium] |
| HPA:0640692 | 0.00568622014719 | 0.4 | CALD1 MYLK | endometrium; smooth muscle cells[>=Medium] |
| HPA:0470203 | 0.00728144353478 | 0.6 | MAP4 CALD1 MYLK | skin 2; endothelial cells[High] |
| HPA:0641521 | 0.00989213643332 | 0.4 | CALD1 MYLK | endometrium; nonciliated luminal epithelial cells[>=Low] |
| REAC:R-HSA-445355 | 0.0100756681589 | 0.4 | CALD1 MYLK | Smooth Muscle Contraction |
| HPA:0640691 | 0.0102944856463 | 0.4 | CALD1 MYLK | endometrium; smooth muscle cells[>=Low] |
| HPA:0641502 | 0.010704797307 | 0.4 | CALD1 MYLK | endometrium; ciliated epithelial cells[>=Medium] |
| HPA:0641501 | 0.0157428028711 | 0.4 | CALD1 MYLK | endometrium; ciliated epithelial cells[>=Low] |
| KEGG:04270 | 0.0204627079102 | 0.4 | CALD1 MYLK | Vascular smooth muscle contraction |
| HPA:0640000 | 0.0343425608627 | 0.4 | CALD1 MYLK | endometrium |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAP4 | CALD1 | 0.985 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | |
| CALD1 | TJP2 | 0.974 | hein_WMM bioplex3_WMM gupta_WMM WMM_only | |
| API5 | CALD1 | 0.962 | bioplex_WMM bioplex3_WMM gupta_WMM fraction treiber_WMM | |
| CALD1 | APEX1 | 0.961 | bioplex_WMM bioplex3_WMM gupta_WMM fraction | |
| MYLK | TJP2 | 0.953 | 0.052 | hein_WMM youn_WMM WMM_only |
| MAP4 | APEX1 | 0.722 | bioplex () bioplex_WMM bioplex3_WMM gupta_WMM boldt_WMM treiber_WMM | |
| API5 | APEX1 | 0.485 | 0.438 | bioplex () bioplex_WMM bioplex3_WMM gupta_WMM fraction treiber_WMM |
| API5 | MAP4 | 0.23 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| CALD1 | MYLK | 0.226 | hein_WMM WMM_only | |
| API5 | MYLK | 0.014 | 0.068 | youn_WMM WMM_only |
| MAP4 | TJP2 | 0.013 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| MAP4 | MYLK | 0.012 | youn_WMM WMM_only | |
| APEX1 | TJP2 | 0.008 | 0.392 | bioplex3_WMM gupta_WMM WMM_only |
| API5 | TJP2 | 0.001 | 0.202 | bioplex3_WMM youn_WMM gupta_WMM fraction |
Related Complexes