hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11076.1
Complex Portal: CPX-24591
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CORO1A | Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO) | 5 | UniProt NCBI |
| WDR1 | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | 5 | UniProt NCBI |
| CFL1 | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) | 5 | UniProt NCBI |
| CORO1B | Coronin-1B (Coronin-2) | 5 | UniProt NCBI |
| CORO6 | Coronin-6 (Coronin-like protein E) (Clipin-E) | 4 | UniProt NCBI |
| AFAP1 | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | 5 | UniProt NCBI |
| SYNPO | Synaptopodin | 5 | UniProt NCBI |
| DSTN | Destrin (Actin-depolymerizing factor) (ADF) | 5 | UniProt NCBI |
| CFL2 | Cofilin-2 (Cofilin, muscle isoform) | 5 | UniProt NCBI |
| CORO1C | Coronin-1C (Coronin-3) (hCRNN4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0003779 | 1.32004918684e-10 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | actin binding |
| GO:0051015 | 5.97205035095e-10 | 0.8 | CFL1 CFL2 DSTN WDR1 CORO1C CORO1A CORO1B CORO6 | actin filament binding |
| GO:0007015 | 8.12575671644e-10 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | actin filament organization |
| GO:0015629 | 2.19638778689e-09 | 0.9 | CFL1 CFL2 DSTN WDR1 AFAP1 CORO1C CORO1A CORO1B SYNPO | actin cytoskeleton |
| GO:0030036 | 4.99920109885e-08 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | actin cytoskeleton organization |
| GO:0030029 | 1.33450530331e-07 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | actin filament-based process |
| GO:0097435 | 1.62343621351e-07 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | supramolecular fiber organization |
| GO:0008092 | 6.86895064999e-07 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | cytoskeletal protein binding |
| GO:0030043 | 1.15344049292e-05 | 0.3 | CFL1 DSTN CFL2 | actin filament fragmentation |
| GO:0007010 | 3.56434715953e-05 | 0.9 | CORO1C CFL1 CFL2 DSTN WDR1 SYNPO CORO1A CORO1B CORO6 | cytoskeleton organization |
| GO:0030042 | 0.000361003342891 | 0.4 | WDR1 CFL2 DSTN CFL1 | actin filament depolymerization |
| GO:0005856 | 0.000650754322627 | 0.9 | CFL1 CFL2 DSTN WDR1 AFAP1 CORO1C CORO1A CORO1B SYNPO | cytoskeleton |
| GO:0044877 | 0.00293647708351 | 0.8 | CFL1 CFL2 DSTN WDR1 CORO1C CORO1A CORO1B CORO6 | protein-containing complex binding |
| GO:0110053 | 0.00321315142279 | 0.5 | CORO1A SYNPO CFL2 CORO1B WDR1 | regulation of actin filament organization |
| GO:0051014 | 0.00642915610421 | 0.3 | CFL1 DSTN CFL2 | actin filament severing |
| GO:0051261 | 0.00941974755121 | 0.4 | WDR1 CFL2 DSTN CFL1 | protein depolymerization |
| GO:0032956 | 0.0114022498138 | 0.5 | CORO1A SYNPO CFL2 CORO1B WDR1 | regulation of actin cytoskeleton organization |
| GO:0032970 | 0.0197078650144 | 0.5 | CORO1A SYNPO CFL2 CORO1B WDR1 | regulation of actin filament-based process |
| WP:WP524 | 0.0216520902792 | 0.2 | CFL1 CFL2 | G13 signaling pathway |
| GO:1902903 | 0.0237835996432 | 0.5 | CORO1A SYNPO CFL2 CORO1B WDR1 | regulation of supramolecular fiber organization |
| KEGG:05133 | 0.0355555587532 | 0.2 | CFL1 CFL2 | Pertussis |
| GO:0008154 | 0.0436892060701 | 0.4 | WDR1 CFL2 DSTN CFL1 | actin polymerization or depolymerization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CORO1B | CORO1A | 0.999 | 0.104 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| CORO6 | CORO1A | 0.999 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CORO1B | CORO1C | 0.999 | 0.188 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CFL2 | CFL1 | 0.999 | 0.918 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| CFL2 | CORO1C | 0.999 | 0.178 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| CORO6 | CORO1C | 0.999 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| CORO1A | CORO1C | 0.998 | 0.08 |
mutually_exclusive (Q9BR76)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| CORO6 | CORO1B | 0.998 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| DSTN | AFAP1 | 0.993 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| WDR1 | CORO1C | 0.991 | 0.362 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM | |
| CFL1 | DSTN | 0.983 | 0.572 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| DSTN | CORO1C | 0.981 | 0.304 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| CFL2 | DSTN | 0.979 | 0.476 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| CFL1 | CORO1C | 0.965 | 0.184 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SYNPO | CORO1C | 0.963 | hein_WMM hein () | ||
| CORO1C | AFAP1 | 0.963 | hein_WMM hein () | ||
| CFL1 | AFAP1 | 0.952 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| WDR1 | CFL2 | 0.95 | 0.298 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction | |
| CORO1B | CFL2 | 0.938 | 0.17 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| WDR1 | CFL1 | 0.925 | 0.518 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| CORO1B | WDR1 | 0.908 | 0.266 | hein_WMM bioplex_WMM bioplex3_WMM fraction treiber_WMM | |
| WDR1 | DSTN | 0.901 | 0.474 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| SYNPO | DSTN | 0.781 | hein_WMM WMM_only | ||
| SYNPO | AFAP1 | 0.773 | hein_WMM WMM_only | ||
| WDR1 | AFAP1 | 0.773 | hein_WMM WMM_only | ||
| CORO1B | SYNPO | 0.773 | hein_WMM WMM_only | ||
| CORO1B | AFAP1 | 0.773 | hein_WMM WMM_only | ||
| CFL2 | AFAP1 | 0.773 | hein_WMM WMM_only | ||
| SYNPO | CFL1 | 0.764 | hein_WMM WMM_only | ||
| SYNPO | WDR1 | 0.764 | hein_WMM WMM_only | ||
| CORO1B | DSTN | 0.758 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| CORO1B | CFL1 | 0.74 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SYNPO | CFL2 | 0.351 | hein_WMM WMM_only | ||
| CORO1A | DSTN | 0.065 | 0.07 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CORO6 | DSTN | 0.062 | 0.058 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CORO1A | CFL2 | 0.019 | 0.104 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CORO6 | CFL2 | 0.019 | 0.12 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| CORO6 | CFL1 | 0.006 | 0.2 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| CORO1A | WDR1 | 0.005 | 0.41 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction treiber_WMM | |
| CORO1A | CFL1 | 0.003 | 0.396 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| CORO6 | WDR1 | 0.002 | 0.146 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes