hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11078.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EFNB2 | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | 5 | UniProt NCBI |
| C22orf42 | Uncharacterized protein C22orf42 | 1 | UniProt NCBI |
| RADIL | Ras-associating and dilute domain-containing protein | 5 | UniProt NCBI |
| EPHA5 | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | 5 | UniProt NCBI |
| SDC3 | Syndecan-3 (SYND3) | 5 | UniProt NCBI |
| EPHB3 | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3928665 | 9.30143006941e-05 | 0.5 | EPHB3 EFNB2 EPHA5 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-2682334 | 0.000618329565809 | 0.5 | EPHB3 EFNB2 EPHA5 | EPH-Ephrin signaling |
| KEGG:04360 | 0.00116048290445 | 0.5 | EPHB3 EFNB2 EPHA5 | Axon guidance |
| REAC:R-HSA-3928664 | 0.00309047926945 | 0.333333333333 | EFNB2 EPHB3 | Ephrin signaling |
| GO:0048013 | 0.017471616814 | 0.5 | EPHB3 EFNB2 EPHA5 | ephrin receptor signaling pathway |
| REAC:R-HSA-3928662 | 0.0180324600743 | 0.333333333333 | EFNB2 EPHB3 | EPHB-mediated forward signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EFNB2 | SDC3 | 0.986 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EPHB3 | EFNB2 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| EFNB2 | RADIL | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EPHA5 | C22orf42 | 0.956 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EFNB2 | EPHA5 | 0.953 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EPHB3 | SDC3 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPHB3 | RADIL | 0.3 | bioplex_WMM bioplex3_WMM WMM_only | |
| SDC3 | EPHA5 | 0.224 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| EPHB3 | EPHA5 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | |
| RADIL | EPHA5 | 0.212 | bioplex_WMM bioplex3_WMM WMM_only | |
| SDC3 | RADIL | 0.188 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes