hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11090.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SETD6 | N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6) | 5 | UniProt NCBI |
| RPS4Y2 | Small ribosomal subunit protein eS4, Y isoform 2 (40S ribosomal protein S4, Y isoform 2) | 2 | UniProt NCBI |
| RPS4Y1 | Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) | 4 | UniProt NCBI |
| RPL36AL | Ribosomal protein eL42-like (60S ribosomal protein L36a-like) (Large ribosomal subunit protein eL42-like) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03010 | 0.000122013372793 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Ribosome |
| REAC:R-HSA-192823 | 0.000153311097908 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Viral mRNA Translation |
| REAC:R-HSA-156902 | 0.000153311097908 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Peptide chain elongation |
| REAC:R-HSA-2408557 | 0.000169699262125 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Selenocysteine synthesis |
| REAC:R-HSA-72764 | 0.000169699262125 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Eukaryotic Translation Termination |
| REAC:R-HSA-156842 | 0.000175410417245 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Eukaryotic Translation Elongation |
| REAC:R-HSA-975956 | 0.000187213642192 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-9633012 | 0.000225769742075 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| REAC:R-HSA-72689 | 0.000225769742075 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Formation of a pool of free 40S subunits |
| REAC:R-HSA-1799339 | 0.000301178051097 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-156827 | 0.000301178051097 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-2408522 | 0.000309528132151 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Selenoamino acid metabolism |
| REAC:R-HSA-72706 | 0.000309528132151 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-927802 | 0.000335499618459 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-975957 | 0.000335499618459 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-72737 | 0.000372329018867 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 0.000372329018867 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Eukaryotic Translation Initiation |
| KEGG:05171 | 0.000459857531952 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Coronavirus disease - COVID-19 |
| REAC:R-HSA-168273 | 0.000510403660163 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-168255 | 0.000737326259628 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Influenza Infection |
| REAC:R-HSA-9711097 | 0.00081494341463 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Cellular response to starvation |
| REAC:R-HSA-9010553 | 0.00104173974765 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-6791226 | 0.00132908901162 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.00156371199708 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.00182434362823 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | rRNA processing |
| REAC:R-HSA-376176 | 0.00211233137107 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Signaling by ROBO receptors |
| REAC:R-HSA-72766 | 0.00544769255683 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Translation |
| REAC:R-HSA-9735869 | 0.0068064250699 | 0.5 | RPS4Y2 RPS4Y1 | SARS-CoV-1 modulates host translation machinery |
| REAC:R-HSA-71291 | 0.007608748274 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Metabolism of amino acids and derivatives |
| REAC:R-HSA-9754678 | 0.0130136556072 | 0.5 | RPS4Y2 RPS4Y1 | SARS-CoV-2 modulates host translation machinery |
| REAC:R-HSA-72695 | 0.0135329645116 | 0.5 | RPS4Y2 RPS4Y1 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72702 | 0.0174510452107 | 0.5 | RPS4Y2 RPS4Y1 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0174510452107 | 0.5 | RPS4Y2 RPS4Y1 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0180511544442 | 0.5 | RPS4Y2 RPS4Y1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Axon guidance |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | RPL36AL RPS4Y2 RPS4Y1 | Nervous system development |
| REAC:R-HSA-9692914 | 0.0434971593242 | 0.5 | RPS4Y2 RPS4Y1 | SARS-CoV-1-host interactions |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS4Y2 | RPS4Y1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| SETD6 | RPL36AL | 0.969 | 0.138 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPS4Y2 | RPL36AL | 0.952 | bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| RPS4Y2 | SETD6 | 0.188 | bioplex3_WMM WMM_only | |
| RPS4Y1 | RPL36AL | 0.115 | 0.066 | bioplex3_WMM WMM_only treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| SETD6 | huMAP3_03384.1 huMAP3_05935.1 huMAP3_11090.1 huMAP3_14873.1 |
| RPS4Y2 | huMAP3_00399.1 huMAP3_01196.1 huMAP3_05607.1 huMAP3_11090.1 |
| RPS4Y1 | huMAP3_00399.1 huMAP3_01923.1 huMAP3_11090.1 huMAP3_13090.1 |
| RPL36AL | huMAP3_03384.1 huMAP3_05807.1 huMAP3_05935.1 huMAP3_11090.1 huMAP3_14873.1 |