hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11098.1
Complex Portal: CPX-15920
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEK6 | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | 5 | UniProt NCBI |
| ANKS6 | Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) | 5 | UniProt NCBI |
| NEK9 | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | 5 | UniProt NCBI |
| NEK7 | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | 5 | UniProt NCBI |
| ANKS3 | Ankyrin repeat and SAM domain-containing protein 3 | 5 | UniProt NCBI |
| ZNF214 | Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2980767 | 2.47215416054e-07 | 0.5 | NEK6 NEK9 NEK7 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| REAC:R-HSA-3301854 | 3.83832488858e-05 | 0.5 | NEK6 NEK9 NEK7 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-2980766 | 0.000113827315454 | 0.5 | NEK6 NEK9 NEK7 | Nuclear Envelope Breakdown |
| REAC:R-HSA-9648025 | 0.00162692918042 | 0.5 | NEK6 NEK9 NEK7 | EML4 and NUDC in mitotic spindle formation |
| WP:WP4803 | 0.00167174375179 | 0.5 | ANKS6 NEK9 ANKS3 | Ciliopathies |
| REAC:R-HSA-68875 | 0.00204866370827 | 0.5 | NEK6 NEK9 NEK7 | Mitotic Prophase |
| WP:WP4352 | 0.00400681842466 | 0.5 | ANKS6 NEK7 ANKS3 | Ciliary landscape |
| REAC:R-HSA-68877 | 0.00834875761735 | 0.5 | NEK6 NEK9 NEK7 | Mitotic Prometaphase |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NEK7 | NEK9 | 0.998 | 0.044 |
mutually_exclusive (Q9HC98)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| NEK6 | NEK9 | 0.998 | 0.05 |
mutually_exclusive (Q8TDX7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEK6 | NEK7 | 0.997 | 0.338 |
mutually_exclusive (Q8TD19)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| NEK7 | ANKS3 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| ANKS3 | ANKS6 | 0.989 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | ||
| NEK6 | ANKS3 | 0.973 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ANKS3 | ZNF214 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NEK7 | ANKS6 | 0.869 | 0.082 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| NEK9 | ANKS3 | 0.57 |
mutually_exclusive (Q8TDX7)
|
bioplex3_WMM boldt boldt_WMM WMM_only | |
| NEK7 | ZNF214 | 0.337 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| NEK6 | ANKS6 | 0.175 | 0.076 | bioplex3_WMM WMM_only | |
| NEK9 | ANKS6 | 0.019 | 0.1 | bioplex3_WMM gupta_WMM WMM_only |
Related Complexes