hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11109.1
Complex Portal: CPX-22731
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WDHD1 | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | 5 | UniProt NCBI |
| SFT2D2 | Vesicle transport protein SFT2B (SFT2 domain-containing protein 2) | 5 | UniProt NCBI |
| SPOP | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | 5 | UniProt NCBI |
| XCL1 | Lymphotactin (ATAC) (C motif chemokine 1) (Cytokine SCM-1) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1) | 5 | UniProt NCBI |
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | 5 | UniProt NCBI |
| KPNA5 | Importin subunit alpha-6 (Karyopherin subunit alpha-5) | 5 | UniProt NCBI |
| SPOPL | Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04340 | 0.0100614067411 | 0.285714285714 | SPOPL SPOP | Hedgehog signaling pathway |
| WP:WP4249 | 0.0117684016707 | 0.285714285714 | SPOPL SPOP | Hedgehog signaling pathway |
| REAC:R-HSA-168276 | 0.0251789059 | 0.285714285714 | NUP50 KPNA5 | NS1 Mediated Effects on Host Pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NUP50 | KPNA5 | 0.998 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SPOPL | SPOP | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPOP | NUP50 | 0.997 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| SPOPL | KPNA5 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPOP | KPNA5 | 0.994 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| XCL1 | SPOPL | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SFT2D2 | SPOPL | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SPOPL | NUP50 | 0.979 |
mutually_exclusive (O15131)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUP50 | WDHD1 | 0.963 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| SFT2D2 | XCL1 | 0.415 | bioplex3_WMM WMM_only | ||
| SPOP | WDHD1 | 0.206 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| SFT2D2 | SPOP | 0.113 | 0.104 | bioplex3_WMM WMM_only | |
| XCL1 | SPOP | 0.078 | bioplex3_WMM WMM_only | ||
| SFT2D2 | KPNA5 | 0.076 | 0.112 | bioplex3_WMM WMM_only | |
| XCL1 | KPNA5 | 0.074 | bioplex3_WMM WMM_only | ||
| SPOPL | WDHD1 | 0.042 | bioplex3_WMM WMM_only | ||
| KPNA5 | WDHD1 | 0.039 | 0.144 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SFT2D2 | NUP50 | 0.024 | 0.028 | bioplex3_WMM gupta_WMM WMM_only | |
| XCL1 | NUP50 | 0.007 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes