hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11115.1
Complex Portal: CPX-22031
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EEFSEC | Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) | 5 | UniProt NCBI |
| MROH1 | Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) | 3 | UniProt NCBI |
| RPS27 | Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) | 5 | UniProt NCBI |
| RPS27L | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2408557 | 0.000169699262125 | 0.75 | EEFSEC RPS27 RPS27L | Selenocysteine synthesis |
| REAC:R-HSA-2408522 | 0.000309528132151 | 0.75 | EEFSEC RPS27 RPS27L | Selenoamino acid metabolism |
| REAC:R-HSA-9735869 | 0.0068064250699 | 0.5 | RPS27 RPS27L | SARS-CoV-1 modulates host translation machinery |
| REAC:R-HSA-71291 | 0.007608748274 | 0.75 | EEFSEC RPS27 RPS27L | Metabolism of amino acids and derivatives |
| REAC:R-HSA-9754678 | 0.0130136556072 | 0.5 | RPS27 RPS27L | SARS-CoV-2 modulates host translation machinery |
| REAC:R-HSA-72695 | 0.0135329645116 | 0.5 | RPS27 RPS27L | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72649 | 0.0174510452107 | 0.5 | RPS27 RPS27L | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.0174510452107 | 0.5 | RPS27 RPS27L | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 0.0180511544442 | 0.5 | RPS27 RPS27L | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| KEGG:03010 | 0.0207865818092 | 0.5 | RPS27 RPS27L | Ribosome |
| REAC:R-HSA-156902 | 0.0389395459224 | 0.5 | RPS27 RPS27L | Peptide chain elongation |
| REAC:R-HSA-192823 | 0.0389395459224 | 0.5 | RPS27 RPS27L | Viral mRNA Translation |
| REAC:R-HSA-72764 | 0.041644107744 | 0.5 | RPS27 RPS27L | Eukaryotic Translation Termination |
| REAC:R-HSA-156842 | 0.0425656343513 | 0.5 | RPS27 RPS27L | Eukaryotic Translation Elongation |
| REAC:R-HSA-9692914 | 0.0434971593242 | 0.5 | RPS27 RPS27L | SARS-CoV-1-host interactions |
| REAC:R-HSA-975956 | 0.0444386798825 | 0.5 | RPS27 RPS27L | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| KEGG:05171 | 0.049994875911 | 0.5 | RPS27 RPS27L | Coronavirus disease - COVID-19 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPS27L | RPS27 | 0.997 | 0.748 |
mutually_exclusive (P78346)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| RPS27 | EEFSEC | 0.981 | 0.284 | hein_WMM bioplex3_HEK293 WMM_only | |
| MROH1 | RPS27 | 0.961 | 0.014 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RPS27L | MROH1 | 0.103 | 0.02 | bioplex3_WMM WMM_only | |
| RPS27L | EEFSEC | 0.067 | 0.08 | hein_WMM bioplex3_HEK293 WMM_only |
Related Complexes