hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11118.1

Complex Portal: CPX-17646

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
RAB7A	Ras-related protein Rab-7a (EC 3.6.5.2)	5	UniProt NCBI
RAP1B	Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)	5	UniProt NCBI
RRAS	Ras-related protein R-Ras (EC 3.6.5.-) (p23)	5	UniProt NCBI
RAB14	Ras-related protein Rab-14	5	UniProt NCBI
RAP2C	Ras-related protein Rap-2c (EC 3.6.5.2)	5	UniProt NCBI
RAB1A	Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein)	5	UniProt NCBI
RAC3	Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)	5	UniProt NCBI
RAP1A	Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)	5	UniProt NCBI
RRAS2	Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene)	5	UniProt NCBI
RAB5C	Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0003924	4.03471790425e-12	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	GTPase activity
GO:0019003	3.50553764221e-11	0.777777777778	RAP2C RRAS2 RAP1A RAB7A RAP1B RAB14 RAB5C	GDP binding
GO:0017111	1.71520263917e-10	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	ribonucleoside triphosphate phosphatase activity
GO:0032561	4.03512211403e-10	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	guanyl ribonucleotide binding
GO:0019001	4.20566202611e-10	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	guanyl nucleotide binding
GO:0016462	4.93748576731e-10	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	pyrophosphatase activity
GO:0016817	4.93748576731e-10	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	hydrolase activity, acting on acid anhydrides
GO:0016818	4.93748576731e-10	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0005525	5.52095297604e-08	0.777777777778	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14	GTP binding
GO:0032555	5.05354728169e-07	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	purine ribonucleotide binding
GO:0032553	5.78040891337e-07	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	ribonucleotide binding
WP:WP4223	1.07022725358e-06	0.555555555556	RAB5C RAP1B RRAS2 RAC3 RAP1A	Ras signaling
GO:0017076	1.35517561568e-06	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	purine nucleotide binding
KEGG:04014	1.83196641183e-06	0.555555555556	RAB5C RAP1B RRAS2 RAC3 RAP1A	Ras signaling pathway
GO:0000166	4.13147669612e-06	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	nucleotide binding
GO:1901265	4.18548446359e-06	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	nucleoside phosphate binding
GO:1901363	7.17675875301e-06	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	heterocyclic compound binding
REAC:R-HSA-8873719	8.62700529853e-06	0.444444444444	RAB7A RAB5C RAB1A RAB14	RAB geranylgeranylation
GO:0097367	9.11262270454e-06	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	carbohydrate derivative binding
REAC:R-HSA-6798695	1.14126161297e-05	0.666666666667	RAP2C RAP1A RAB7A RAP1B RAB14 RAB5C	Neutrophil degranulation
GO:0035639	2.51002472958e-05	0.777777777778	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14	purine ribonucleoside triphosphate binding
REAC:R-HSA-8876198	2.55956250181e-05	0.444444444444	RAB7A RAB5C RAB1A RAB14	RAB GEFs exchange GTP for GDP on RABs
GO:0043168	3.65142143539e-05	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	anion binding
GO:0030667	6.37667834008e-05	0.666666666667	RAP2C RAP1A RAB7A RAP1B RAB14 RAB5C	secretory granule membrane
GO:0016787	7.26346940542e-05	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	hydrolase activity
KEGG:04024	8.0308930152e-05	0.444444444444	RAP1B RRAS2 RAC3 RAP1A	cAMP signaling pathway
REAC:R-HSA-9007101	8.18366619652e-05	0.444444444444	RAB7A RAB5C RAB1A RAB14	Rab regulation of trafficking
GO:0070062	0.000373674637146	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	extracellular exosome
WP:WP382	0.00037823056716	0.444444444444	RAP1B RRAS2 RAC3 RAP1A	MAPK signaling pathway
GO:1903561	0.000406158005187	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	extracellular vesicle
GO:0043230	0.000408144647603	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	extracellular organelle
GO:0065010	0.000408144647603	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	extracellular membrane-bounded organelle
KEGG:04010	0.000444838463051	0.444444444444	RAP1B RRAS2 RAC3 RAP1A	MAPK signaling pathway
KEGG:04520	0.000814374186211	0.333333333333	RAP1B RAC3 RAP1A	Adherens junction
REAC:R-HSA-168249	0.000840607349289	0.666666666667	RAP2C RAP1A RAB7A RAP1B RAB14 RAB5C	Innate Immune System
KEGG:04137	0.00120583060025	0.333333333333	RAB7A RRAS2 RAB5C	Mitophagy - animal
WP:WP185	0.00136924947295	0.333333333333	RAP1B RAC3 RAP1A	Integrin mediated cell adhesion
GO:0030659	0.00151363658534	0.777777777778	RAP2C RAP1A RAB7A RAP1B RAB14 RAB1A RAB5C	cytoplasmic vesicle membrane
GO:0012506	0.00168947867145	0.777777777778	RAP2C RAP1A RAB7A RAP1B RAB14 RAB1A RAB5C	vesicle membrane
GO:0032486	0.00177138039123	0.333333333333	RAP1B RAP1A RAP2C	Rap protein signal transduction
KEGG:04148	0.00243900744737	0.333333333333	RAB7A RAB5C RAB14	Efferocytosis
KEGG:04062	0.00342866970736	0.333333333333	RAP1B RAC3 RAP1A	Chemokine signaling pathway
REAC:R-HSA-8875555	0.00358554253109	0.222222222222	RAP1B RAP1A	MET activates RAP1 and RAC1
REAC:R-HSA-354194	0.00438093013445	0.222222222222	RAP1B RAP1A	GRB2:SOS provides linkage to MAPK signaling for Integrins
WP:WP4301	0.00468193988771	0.222222222222	RAB5C RRAS2	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
KEGG:04140	0.00483284608142	0.333333333333	RAB7A RRAS2 RAB1A	Autophagy - animal
GO:0043167	0.00497987143669	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	ion binding
WP:WP1981	0.0052310849594	0.222222222222	RAP1B RAP1A	Thyroxine thyroid hormone production
REAC:R-HSA-372708	0.00525543712779	0.222222222222	RAP1B RAP1A	p130Cas linkage to MAPK signaling for integrins
KEGG:04015	0.00581188411713	0.333333333333	RAP1B RAC3 RAP1A	Rap1 signaling pathway
MIRNA:hsa-miR-19a-3p	0.00598888908919	0.666666666667	RAP2C RRAS2 RAP1A RAB14 RAP1B RAB1A	hsa-miR-19a-3p
KEGG:04510	0.00656916301355	0.333333333333	RAP1B RAC3 RAP1A	Focal adhesion
REAC:R-HSA-392517	0.00724150508664	0.222222222222	RAP1B RAP1A	Rap1 signalling
GO:0005615	0.00730177587354	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	extracellular space
GO:0031410	0.0109403276913	0.888888888889	RAP2C RAC3 RAP1A RAB7A RAP1B RAB14 RAB1A RAB5C	cytoplasmic vesicle
GO:0097708	0.0110977854262	0.888888888889	RAP2C RAC3 RAP1A RAB7A RAP1B RAB14 RAB1A RAB5C	intracellular vesicle
WP:WP306	0.0118556609861	0.333333333333	RAP1B RAC3 RAP1A	Focal adhesion
GO:0036094	0.0120846567052	0.888888888889	RAP2C RAP1A RAC3 RAB7A RRAS2 RAP1B RAB14 RAB5C	small molecule binding
GO:0045920	0.0123615112794	0.333333333333	RAB7A RAP1A RAP1B	negative regulation of exocytosis
WP:WP313	0.0132604628613	0.222222222222	RAP1B RAP1A	Hepatocyte growth factor receptor signaling
WP:WP2636	0.0151103173393	0.222222222222	RAP1B RAP1A	Common pathways underlying drug addiction
REAC:R-HSA-354192	0.0166738379974	0.222222222222	RAP1B RAP1A	Integrin signaling
GO:0005576	0.0175413137939	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	extracellular region
GO:0016192	0.0208703166512	0.777777777778	RAB14 RAC3 RAP1A RAB7A RAP1B RAB1A RAB5C	vesicle-mediated transport
MIRNA:hsa-miR-19b-3p	0.0237730966843	0.666666666667	RAP2C RRAS2 RAP1A RAB14 RAP1B RAB1A	hsa-miR-19b-3p
KEGG:04720	0.0239862693019	0.222222222222	RAP1B RAP1A	Long-term potentiation
GO:0007264	0.0256244466091	0.555555555556	RAP1B RRAS2 RAC3 RAP1A RAP2C	small GTPase-mediated signal transduction
GO:0030141	0.0283261218171	0.666666666667	RAP2C RAP1A RAB7A RAP1B RAB14 RAB5C	secretory granule
REAC:R-HSA-76009	0.0299458635385	0.222222222222	RAP1B RAP1A	Platelet Aggregation (Plug Formation)
GO:0031982	0.0299859493569	1.0	RAP2C RAC3 RAP1A RAB7A RRAS2 RAP1B RAB14 RAB1A RAB5C	vesicle
REAC:R-HSA-168256	0.0342353908338	0.666666666667	RAP2C RAP1A RAB7A RAP1B RAB14 RAB5C	Immune System
REAC:R-HSA-6802948	0.0344394959621	0.222222222222	RAP1B RAP1A	Signaling by high-kinase activity BRAF mutants
KEGG:05211	0.0347423807791	0.222222222222	RAP1B RAP1A	Renal cell carcinoma
GO:0010008	0.0397491644308	0.555555555556	RAP2C RAB7A RAB5C RAP1A RAB14	endosome membrane
KEGG:04972	0.0425976239187	0.222222222222	RAP1B RAP1A	Pancreatic secretion
REAC:R-HSA-8875878	0.0443583465173	0.222222222222	RAP1B RAP1A	MET promotes cell motility
REAC:R-HSA-5674135	0.0443583465173	0.222222222222	RAP1B RAP1A	MAP2K and MAPK activation
WP:WP2032	0.0449082842831	0.222222222222	RAP1B RAP1A	Thyroid stimulating hormone TSH signaling pathway
REAC:R-HSA-9656223	0.0470317013402	0.222222222222	RAP1B RAP1A	Signaling by RAF1 mutants
GO:0061028	0.0478559415828	0.333333333333	RAP1B RAP1A RAP2C	establishment of endothelial barrier
WP:WP4205	0.0482342246392	0.222222222222	RAP1B RAP1A	MET in type 1 papillary renal cell carcinoma

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RAB7A	RAP1B	0.999	0.422		hein_WMM bioplex_WMM Guru bioplex3_WMM boldt gupta_WMM fraction boldt_WMM
RAB14	RAB7A	0.999	0.514	mutually_exclusive (P31150)	hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only
RRAS	RRAS2	0.997	0.562		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB1A	RAB7A	0.996	0.784	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RRAS2	RAP2C	0.993	0.078		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RAB14	RAB1A	0.993	0.776		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RAB5C	RAP1A	0.993	0.506		hein_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction
RRAS2	RAP1B	0.992	0.094		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RRAS2	RAP1A	0.99	0.1		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
RAB5C	RAB14	0.99	0.828		hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only
RAB5C	RRAS2	0.989	0.216		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
RAC3	RAP1A	0.988	0.086		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB14	RAP1B	0.98	0.446		hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
RAB5C	RAB7A	0.978	0.602		hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAP2C	RAP1A	0.973	0.126		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
RAB1A	RAC3	0.972	0.188		hein_WMM bioplex3_WMM WMM_only
RAB5C	RAB1A	0.971	0.834		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAP1B	RAP1A	0.97	0.882		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
RAC3	RRAS2	0.969	0.154333988212		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB5C	RAC3	0.968	0.49		hein_WMM bioplex3_WMM WMM_only
RAB5C	RAP1B	0.966	0.496		hein_WMM bioplex_WMM Guru bioplex3_WMM boldt gupta_WMM fraction boldt_WMM
RAB5C	RAP2C	0.963	0.292		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
RAC3	RAP1B	0.961	0.0863339882122	mutually_exclusive (P52306)	hein_WMM bioplex_WMM bioplex3_WMM fraction
RAC3	RAP2C	0.961	0.038		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB1A	RRAS2	0.961	0.268		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RAB1A	RAP1A	0.951	0.676		hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
RAB1A	RAP2C	0.946	0.164	structurally_consistent (dimer)	hein_WMM bioplex_WMM Guru bioplex3_WMM fraction
RAB1A	RAP1B	0.926	0.478		hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
RRAS	RAP2C	0.924	0.04		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAP2C	RAP1B	0.915	0.106		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB7A	RAP1A	0.859	0.444		hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction
RAB14	RAP2C	0.69	0.248		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RRAS	RAP1B	0.654	0.182		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB14	RRAS2	0.512	0.128		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RRAS	RAP1A	0.499	0.274		hein_WMM bioplex3_WMM WMM_only
RAB14	RAC3	0.46	0.23		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB14	RAP1A	0.378	0.418		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
RAB7A	RAP2C	0.175	0.22	mutually_exclusive (P62820)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB14	RRAS	0.126	0.17		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB7A	RAC3	0.112	0.464		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB7A	RRAS2	0.072	0.184		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAC3	RRAS	0.061	0.128		hein_WMM bioplex3_WMM WMM_only
RAB1A	RRAS	0.043	0.152		hein_WMM bioplex3_WMM WMM_only
RAB7A	RRAS	0.042	0.222		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RAB5C	RRAS	0.026	0.232833333333		hein_WMM bioplex3_WMM WMM_only bioplex_WMM

Related Complexes

Genename	Complexes
RAB7A	huMAP3_02945.1 huMAP3_06565.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08503.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11118.1
RAP1B	huMAP3_05674.1 huMAP3_06217.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1
RRAS	huMAP3_03705.1 huMAP3_06179.1 huMAP3_08271.1 huMAP3_11118.1 huMAP3_12303.1 huMAP3_12658.1 huMAP3_15136.1
RAB14	huMAP3_01895.1 huMAP3_02945.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11118.1
RAP2C	huMAP3_03804.1 huMAP3_06179.1 huMAP3_06512.1 huMAP3_07045.1 huMAP3_07836.1 huMAP3_09165.1 huMAP3_11118.1
RAB1A	huMAP3_01895.1 huMAP3_02945.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_08941.1 huMAP3_09165.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11118.1
RAC3	huMAP3_03705.1 huMAP3_05480.1 huMAP3_06179.1 huMAP3_06217.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1
RAP1A	huMAP3_06179.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1 huMAP3_11897.1 huMAP3_14124.1
RRAS2	huMAP3_03705.1 huMAP3_05633.1 huMAP3_06179.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1
RAB5C	huMAP3_00855.1 huMAP3_02945.1 huMAP3_05480.1 huMAP3_07239.1 huMAP3_08941.1 huMAP3_08960.1 huMAP3_09217.1 huMAP3_10627.1 huMAP3_11094.1 huMAP3_11118.1 huMAP3_11860.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11118.1

Complex Portal: CPX-17646