List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_11119.1

Confidence: Medium High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
TIMELESS	Protein timeless homolog (hTIM)	5	UniProt   NCBI
MCM3	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	5	UniProt   NCBI
GINS1	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	5	UniProt   NCBI
MCMBP	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	5	UniProt   NCBI
MCM5	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	5	UniProt   NCBI
MCM6	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	5	UniProt   NCBI
CLSPN	Claspin (hClaspin)	5	UniProt   NCBI
GINS2	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	5	UniProt   NCBI
GINS4	DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]	5	UniProt   NCBI
MCM7	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	5	UniProt   NCBI
GINS3	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	5	UniProt   NCBI
TIPIN	TIMELESS-interacting protein	5	UniProt   NCBI
MCM4	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	5	UniProt   NCBI
CDC45	Cell division control protein 45 homolog (PORC-PI-1)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-176974	3.46150205157e-15	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	Unwinding of DNA
GO:0006261	2.7739234778e-13	0.9	MCMBP MCM6 CDC45 TIMELESS GINS1 GINS4 TIPIN GINS2 GINS3	DNA-templated DNA replication
GO:0071162	3.58349586175e-13	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	CMG complex
GO:0031261	7.16530924676e-13	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA replication preinitiation complex
REAC:R-HSA-69190	3.37887701263e-12	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA strand elongation
CORUM:678	8.06664600281e-12	0.4	GINS1 GINS3 GINS2 GINS4	GINS complex
GO:0006260	1.34757221223e-11	0.9	MCMBP MCM6 CDC45 TIMELESS GINS1 GINS4 TIPIN GINS2 GINS3	DNA replication
GO:0006268	4.19910603841e-11	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA unwinding involved in DNA replication
GO:0000228	7.22601911871e-10	0.8	GINS3 MCM6 CDC45 TIMELESS GINS1 GINS4 GINS2 TIPIN	nuclear chromosome
GO:0000811	5.52565251192e-09	0.4	GINS1 GINS3 GINS2 GINS4	GINS complex
GO:0032508	6.26742705426e-09	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA duplex unwinding
REAC:R-HSA-69239	1.26763126221e-08	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	Synthesis of DNA
GO:0032392	1.7632009671e-08	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA geometric change
GO:0071103	3.83871979183e-08	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA conformation change
REAC:R-HSA-69242	7.38143751137e-08	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	S Phase
REAC:R-HSA-69306	1.27386379083e-07	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	DNA Replication
GO:0033260	5.34253802658e-07	0.5	CDC45 GINS1 TIPIN GINS3 MCM6	nuclear DNA replication
GO:0044786	9.80102829112e-07	0.5	CDC45 GINS1 TIPIN GINS3 MCM6	cell cycle DNA replication
GO:0006259	1.32880440525e-06	0.9	MCMBP MCM6 CDC45 TIMELESS GINS1 GINS4 TIPIN GINS2 GINS3	DNA metabolic process
GO:0000727	1.81927560642e-06	0.4	CDC45 MCM6 GINS2 GINS4	double-strand break repair via break-induced replication
GO:1902969	3.93917350423e-06	0.4	CDC45 GINS1 GINS3 MCM6	mitotic DNA replication
REAC:R-HSA-1640170	8.32723293103e-06	0.7	CLSPN GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	Cell Cycle
GO:0000076	1.68308738937e-05	0.4	TIMELESS TIPIN CDC45 CLSPN	DNA replication checkpoint signaling
REAC:R-HSA-69278	9.47504494937e-05	0.6	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2	Cell Cycle, Mitotic
GO:0051276	0.000296937740753	0.7	GINS3 GINS1 CDC45 MCM6 GINS4 GINS2 MCMBP	chromosome organization
REAC:R-HSA-176187	0.000393160884162	0.3	MCM6 CDC45 CLSPN	Activation of ATR in response to replication stress
GO:0022402	0.000792598743402	0.8	CLSPN GINS3 MCM6 CDC45 TIMELESS GINS1 TIPIN MCMBP	cell cycle process
GO:0032993	0.00118321437729	0.8	GINS3 MCM6 CDC45 TIMELESS GINS1 GINS4 GINS2 TIPIN	protein-DNA complex
GO:0000724	0.00167178873394	0.5	CDC45 TIMELESS GINS2 GINS4 MCM6	double-strand break repair via homologous recombination
GO:0000725	0.00189523613818	0.5	CDC45 TIMELESS GINS2 GINS4 MCM6	recombinational repair
GO:0140513	0.00205875531072	0.8	GINS3 MCM6 CDC45 TIMELESS GINS1 GINS4 GINS2 TIPIN	nuclear protein-containing complex
GO:0006974	0.00353710704098	0.7	CLSPN TIPIN CDC45 TIMELESS MCM6 GINS4 GINS2	DNA damage response
GO:0007049	0.00560105754087	0.8	CLSPN GINS3 MCM6 CDC45 TIMELESS GINS1 TIPIN MCMBP	cell cycle
REAC:R-HSA-5693607	0.00634443554182	0.3	TIMELESS TIPIN CLSPN	Processing of DNA double-strand break ends
GO:0005694	0.0129065863791	0.8	GINS3 MCM6 CDC45 TIMELESS GINS1 GINS4 GINS2 TIPIN	chromosome
GO:0006310	0.0155706363437	0.5	CDC45 TIMELESS GINS2 GINS4 MCM6	DNA recombination
REAC:R-HSA-5693567	0.0161495944471	0.3	TIMELESS TIPIN CLSPN	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
REAC:R-HSA-5693538	0.0186112177015	0.3	TIMELESS TIPIN CLSPN	Homology Directed Repair
GO:0006302	0.02422534277	0.5	CDC45 TIMELESS GINS2 GINS4 MCM6	double-strand break repair
REAC:R-HSA-5693532	0.033986572252	0.3	TIMELESS TIPIN CLSPN	DNA Double-Strand Break Repair
REAC:R-HSA-69481	0.0346276551428	0.3	MCM6 CDC45 CLSPN	G2/M Checkpoints
WP:WP466	0.0351918400012	0.2	MCM6 CDC45	DNA replication
GO:0031570	0.0368293644996	0.4	TIMELESS TIPIN CDC45 CLSPN	DNA integrity checkpoint signaling
GO:1903047	0.0417614119535	0.6	CLSPN GINS3 GINS1 CDC45 MCM6 TIPIN	mitotic cell cycle process
GO:0005654	0.042696914045	1.0	CLSPN MCMBP MCM6 CDC45 TIMELESS GINS1 GINS4 TIPIN GINS2 GINS3	nucleoplasm
CORUM:2791	0.0499436884912	0.1	MCM6	MCM4-MCM6-MCM7 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
GINS2	GINS4	1.0	0.93
MCMBP	MCM5	1.0	0.314
GINS3	GINS1	1.0	0.93
TIPIN	TIMELESS	1.0	0.216
GINS2	GINS1	1.0	0.838
MCM6	MCM4	1.0	0.986
GINS2	GINS3	1.0	0.908
GINS4	GINS1	1.0	0.836
GINS4	GINS3	1.0	0.922
MCM4	MCM7	1.0	0.988
MCM3	MCMBP	0.999	0.254486486486
MCM3	MCM5	0.999	0.962
MCM4	MCM5	0.999	0.97
MCM6	MCM7	0.999	0.974
MCM3	MCM4	0.999	0.988
MCM3	MCM6	0.999	0.974
MCM4	TIPIN	0.999	0.384
MCM5	MCM7	0.998	0.98
MCMBP	MCM6	0.998	0.304
GINS4	TIMELESS	0.998	0.204
MCM3	MCM7	0.998	0.986
MCM6	MCM5	0.997	0.98
GINS4	TIPIN	0.997	0.09
MCMBP	MCM7	0.996	0.396
CLSPN	GINS4	0.996	0.12
TIPIN	GINS3	0.996	0.084
CLSPN	TIMELESS	0.995	0.124
TIMELESS	CDC45	0.995	0.416
GINS3	TIMELESS	0.995	0.158
MCM6	TIMELESS	0.995	0.476
TIPIN	MCM7	0.994	0.402
MCM3	GINS4	0.994	0.256
MCM3	GINS3	0.993	0.646
MCM3	TIPIN	0.992	0.236
MCM6	TIPIN	0.991	0.374
MCM4	TIMELESS	0.991	0.382
MCM6	GINS3	0.991	0.764
MCM6	GINS4	0.989	0.54
MCM4	GINS3	0.989	0.642
GINS4	MCM7	0.989	0.59
CLSPN	TIPIN	0.988	0.22
MCM7	TIMELESS	0.988	0.464
GINS3	CDC45	0.984	0.474
MCMBP	MCM4	0.98	0.436
MCM3	TIMELESS	0.979	0.342
MCM7	CDC45	0.978	0.49
CLSPN	GINS3	0.978	0.154
GINS1	CDC45	0.976	0.316
TIPIN	MCM5	0.974	0.26
MCM4	GINS4	0.969	0.554
MCM5	TIMELESS	0.967	0.502
MCM3	CLSPN	0.965	0.384
GINS2	MCM5	0.963	0.472
GINS3	MCM5	0.957	0.578
GINS4	MCM5	0.953	0.328
GINS2	TIMELESS	0.952	0.092
GINS2	MCM7	0.939	0.47
MCM6	CLSPN	0.927	0.504
CLSPN	MCM7	0.925	0.516
GINS3	MCM7	0.915	0.516
GINS4	CDC45	0.91	0.198
GINS1	TIMELESS	0.908	0.128
TIPIN	GINS1	0.896	0.104
MCM3	GINS2	0.879	0.302
GINS1	MCM5	0.877	0.594
MCM6	CDC45	0.859	0.418
GINS2	CDC45	0.857	0.124
MCM3	GINS1	0.841	0.404
GINS1	MCM7	0.835	0.592
MCM5	CDC45	0.832	0.426
MCM4	GINS2	0.825	0.614
MCM4	CDC45	0.822	0.476
MCM6	GINS2	0.759	0.666
MCM3	CDC45	0.754	0.354
MCM6	GINS1	0.704	0.412
GINS2	TIPIN	0.699	0.098
CLSPN	CDC45	0.694	0.22
MCM4	GINS1	0.632	0.736
TIPIN	CDC45	0.594	0.122
CLSPN	GINS1	0.568	0.074
GINS2	CLSPN	0.401	0.078
MCM4	CLSPN	0.372	0.576
MCMBP	GINS2	0.105	0.078
MCMBP	TIPIN	0.093	0.09
CLSPN	MCM5	0.064	0.34
MCMBP	GINS1	0.038	0.124
MCMBP	GINS4	0.038	0.166
MCMBP	TIMELESS	0.024	0.074
MCMBP	CLSPN	0.022	0.118
MCMBP	GINS3	0.022	0.084
MCMBP	CDC45	0.01	0.202





Related Complexes

Genename	Complexes
TIMELESS	huMAP3_06136.1 huMAP3_06417.1 huMAP3_07113.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM3	huMAP3_00154.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS1	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCMBP	huMAP3_00154.1 huMAP3_02113.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09860.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM5	huMAP3_05529.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM6	huMAP3_00154.1 huMAP3_02602.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10862.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
CLSPN	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS2	huMAP3_03896.1 huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_13708.1 huMAP3_14758.1
GINS4	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM7	huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS3	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
TIPIN	huMAP3_04079.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM4	huMAP3_00154.1 huMAP3_02602.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10862.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
CDC45	huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1