hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11120.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POMT1 | Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) | 5 | UniProt NCBI |
| POMT2 | Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) | 5 | UniProt NCBI |
| CD244 | Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) | 5 | UniProt NCBI |
| TSPOAP1 | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) | 5 | UniProt NCBI |
| RFTN2 | Raftlin-2 (Raft-linking protein 2) | 3 | UniProt NCBI |
| STEAP2 | Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5083633 | 7.74455426548e-05 | 0.333333333333 | POMT1 POMT2 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 |
| REAC:R-HSA-5083629 | 7.74455426548e-05 | 0.333333333333 | POMT1 POMT2 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 |
| HP:0040173 | 0.00107987178333 | 0.333333333333 | POMT1 POMT2 | Abnormality of the tongue muscle |
| HP:0006888 | 0.00107987178333 | 0.333333333333 | POMT1 POMT2 | Meningoencephalocele |
| HP:0012793 | 0.00161951205762 | 0.333333333333 | POMT1 POMT2 | Kinked brainstem |
| HP:0006899 | 0.00161951205762 | 0.333333333333 | POMT1 POMT2 | Fusion of the cerebellar hemispheres |
| KEGG:00515 | 0.00167329519289 | 0.333333333333 | POMT1 POMT2 | Mannose type O-glycan biosynthesis |
| HP:0030099 | 0.00388470114881 | 0.333333333333 | POMT1 POMT2 | Reduced muscle fiber alpha dystroglycan |
| HP:0030112 | 0.00485499013014 | 0.333333333333 | POMT1 POMT2 | Abnormal muscle fiber alpha dystroglycan |
| HP:0030046 | 0.00485499013014 | 0.333333333333 | POMT1 POMT2 | Hypoglycosylation of alpha-dystroglycan |
| HP:0012695 | 0.00485499013014 | 0.333333333333 | POMT1 POMT2 | Decreased thalamic volume |
| HP:0012693 | 0.00485499013014 | 0.333333333333 | POMT1 POMT2 | Abnormal thalamic size |
| KEGG:00514 | 0.00563154229257 | 0.333333333333 | POMT1 POMT2 | Other types of O-glycan biosynthesis |
| HP:0004637 | 0.00593279372985 | 0.333333333333 | POMT1 POMT2 | Decreased cervical spine mobility |
| HP:0006955 | 0.00841070885474 | 0.333333333333 | POMT1 POMT2 | Olivopontocerebellar hypoplasia |
| HP:0007015 | 0.00981070246055 | 0.333333333333 | POMT1 POMT2 | Poor gross motor coordination |
| HP:0007260 | 0.011317974846 | 0.333333333333 | POMT1 POMT2 | Type II lissencephaly |
| HP:0003707 | 0.0129324670968 | 0.333333333333 | POMT1 POMT2 | Calf muscle pseudohypertrophy |
| HP:0007291 | 0.0129324670968 | 0.333333333333 | POMT1 POMT2 | Posterior fossa cyst |
| HP:0003741 | 0.0146541203169 | 0.333333333333 | POMT1 POMT2 | Congenital muscular dystrophy |
| HP:0031882 | 0.0146541203169 | 0.333333333333 | POMT1 POMT2 | Agyria |
| HP:0008443 | 0.0164828756284 | 0.333333333333 | POMT1 POMT2 | Neuropathic spinal arthropathy |
| HP:0007227 | 0.020461457105 | 0.333333333333 | POMT1 POMT2 | Macrogyria |
| HP:0007731 | 0.020461457105 | 0.333333333333 | POMT1 POMT2 | Chorioretinal dysplasia |
| REAC:R-HSA-3906995 | 0.0220691409046 | 0.333333333333 | POMT1 POMT2 | Diseases associated with O-glycosylation of proteins |
| HP:0000659 | 0.0226111656051 | 0.333333333333 | POMT1 POMT2 | Peters anomaly |
| HP:0010508 | 0.0248677408666 | 0.333333333333 | POMT1 POMT2 | Metatarsus valgus |
| HP:0007033 | 0.0272311241025 | 0.333333333333 | POMT1 POMT2 | Cerebellar dysplasia |
| HP:0012400 | 0.0297012565438 | 0.333333333333 | POMT1 POMT2 | Abnormal circulating aldolase concentration |
| HP:0000557 | 0.0297012565438 | 0.333333333333 | POMT1 POMT2 | Buphthalmos |
| HP:0007973 | 0.0297012565438 | 0.333333333333 | POMT1 POMT2 | Retinal dysplasia |
| HP:0030089 | 0.0406481036194 | 0.333333333333 | POMT1 POMT2 | Abnormal muscle fiber protein expression |
| HP:0007204 | 0.0467604957305 | 0.333333333333 | POMT1 POMT2 | Diffuse white matter abnormalities |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| POMT2 | CD244 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CD244 | POMT1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STEAP2 | CD244 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CD244 | TSPOAP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RFTN2 | POMT2 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RFTN2 | POMT1 | 0.909 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| POMT2 | POMT1 | 0.703 | 0.218 | bioplex_WMM bioplex3_WMM WMM_only |
| STEAP2 | POMT1 | 0.407 | bioplex3_WMM WMM_only | |
| STEAP2 | POMT2 | 0.288 | bioplex3_WMM WMM_only | |
| POMT2 | TSPOAP1 | 0.213 | bioplex_WMM bioplex3_WMM WMM_only | |
| STEAP2 | TSPOAP1 | 0.146 | bioplex3_WMM WMM_only | |
| POMT1 | TSPOAP1 | 0.087 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes