hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11121.1
Complex Portal: CPX-22584
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EPB41L3 | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | 5 | UniProt NCBI |
| WWC1 | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | 5 | UniProt NCBI |
| EPB41 | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | 5 | UniProt NCBI |
| RBFOX1 | RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1) | 5 | UniProt NCBI |
| PRMT5 | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | 5 | UniProt NCBI |
| COPRS | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | 5 | UniProt NCBI |
| FARP2 | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | 5 | UniProt NCBI |
| RIOK1 | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) | 5 | UniProt NCBI |
| WDR77 | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | 5 | UniProt NCBI |
| CIRBP | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6853 | 2.73623797451e-05 | 0.222222222222 | PRMT5 COPRS | COPRS-PRMT5 complex |
| CORUM:837 | 8.20609246787e-05 | 0.222222222222 | PRMT5 WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:2838 | 8.20609246787e-05 | 0.222222222222 | PRMT5 WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:6852 | 0.000164069436391 | 0.222222222222 | PRMT5 COPRS | COPRS-PRMT5-RUNX1-CBFB complex |
| CORUM:6858 | 0.000273361732609 | 0.222222222222 | PRMT5 WDR77 | CHTOP-methylosome complex |
| CORUM:810 | 0.000573693030134 | 0.222222222222 | PRMT5 WDR77 | FCP1-associated protein complex |
| CORUM:811 | 0.000573693030134 | 0.222222222222 | PRMT5 WDR77 | FCP1-associated protein complex |
| REAC:R-HSA-3214858 | 0.00196450797769 | 0.333333333333 | PRMT5 WDR77 COPRS | RMTs methylate histone arginines |
| GO:0048024 | 0.00625820430729 | 0.444444444444 | RBFOX1 WDR77 CIRBP PRMT5 | regulation of mRNA splicing, via spliceosome |
| GO:0048026 | 0.00778531456229 | 0.333333333333 | PRMT5 CIRBP WDR77 | positive regulation of mRNA splicing, via spliceosome |
| GO:0050684 | 0.0154150912184 | 0.444444444444 | RBFOX1 WDR77 CIRBP PRMT5 | regulation of mRNA processing |
| GO:0050685 | 0.0162365457737 | 0.333333333333 | PRMT5 CIRBP WDR77 | positive regulation of mRNA processing |
| GO:0033120 | 0.0325091721374 | 0.333333333333 | PRMT5 CIRBP WDR77 | positive regulation of RNA splicing |
| CORUM:1748 | 0.0499842271994 | 0.111111111111 | PRMT5 | PRMT5 complex |
| CORUM:2764 | 0.0499842271994 | 0.111111111111 | PRMT5 | PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COPRS | WDR77 | 0.999 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM boldt_WMM WMM_only | |
| PRMT5 | WDR77 | 0.999 | 0.914 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| COPRS | RIOK1 | 0.999 | 0.068 |
mutually_exclusive (O14744)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only |
| COPRS | PRMT5 | 0.996 | 0.132 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM |
| PRMT5 | RIOK1 | 0.994 | 0.214 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM |
| RIOK1 | WDR77 | 0.994 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| CIRBP | WDR77 | 0.993 | 0.022 |
structurally_consistent (O14744)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EPB41L3 | EPB41 | 0.991 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only | ||
| COPRS | FARP2 | 0.983 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EPB41L3 | PRMT5 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | ||
| COPRS | CIRBP | 0.981 | 0.032 |
structurally_consistent (O14744)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EPB41L3 | RIOK1 | 0.979 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| COPRS | RBFOX1 | 0.975 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EPB41L3 | WDR77 | 0.975 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | ||
| EPB41L3 | WWC1 | 0.974 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CIRBP | PRMT5 | 0.971 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| FARP2 | PRMT5 | 0.963 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CIRBP | RIOK1 | 0.963 | 0.03 |
structurally_consistent (O14744)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| EPB41 | WWC1 | 0.959 | 0.048 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FARP2 | WDR77 | 0.958 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RBFOX1 | PRMT5 | 0.94 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| FARP2 | RIOK1 | 0.9 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COPRS | EPB41L3 | 0.738 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| RBFOX1 | WDR77 | 0.654 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| RBFOX1 | RIOK1 | 0.563 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FARP2 | EPB41L3 | 0.105 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FARP2 | EPB41 | 0.098 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| FARP2 | WWC1 | 0.034 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EPB41 | PRMT5 | 0.022 | 0.06 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| EPB41 | WDR77 | 0.012 | 0.056 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| PRMT5 | WWC1 | 0.012 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBFOX1 | CIRBP | 0.008 | 0.092 | bioplex3_HEK293 bioplex () | |
| CIRBP | WWC1 | 0.008 | 0.068 | bioplex3_WMM WMM_only | |
| EPB41 | RIOK1 | 0.007 | 0.02 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EPB41 | CIRBP | 0.006 | 0.042 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| EPB41L3 | CIRBP | 0.005 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| COPRS | EPB41 | 0.004 | 0.05 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| FARP2 | CIRBP | 0.002 | 0.062 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes