hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11125.1
Complex Portal: CPX-23363
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DNM1 | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | 5 | UniProt NCBI |
| LYPD6 | Ly6/PLAUR domain-containing protein 6 | 5 | UniProt NCBI |
| FAM118A | Protein FAM118A | 5 | UniProt NCBI |
| ELOVL4 | Very long chain fatty acid elongase 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Elongation of very long chain fatty acids protein 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) | 5 | UniProt NCBI |
| TYROBP | TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein) | 5 | UniProt NCBI |
| DNM2 | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | 5 | UniProt NCBI |
| PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) | 5 | UniProt NCBI |
| PPY | Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)] | 5 | UniProt NCBI |
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 8.39516773096e-06 | 0.333333333333 | DNM1 DNM2 DNM3 | Retrograde neurotrophin signalling |
| KEGG:04961 | 0.00013059415819 | 0.333333333333 | DNM1 DNM2 DNM3 | Endocrine and other factor-regulated calcium reabsorption |
| WP:WP2267 | 0.000179600985894 | 0.333333333333 | DNM1 DNM2 DNM3 | Synaptic vesicle pathway |
| KEGG:04721 | 0.000274501573283 | 0.333333333333 | DNM1 DNM2 DNM3 | Synaptic vesicle cycle |
| KEGG:05100 | 0.000561145056069 | 0.333333333333 | DNM1 DNM2 DNM3 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-437239 | 0.000573226646465 | 0.333333333333 | DNM1 DNM2 DNM3 | Recycling pathway of L1 |
| KEGG:04072 | 0.00199830414065 | 0.333333333333 | DNM1 DNM2 DNM3 | Phospholipase D signaling pathway |
| REAC:R-HSA-196025 | 0.00438093013445 | 0.222222222222 | DNM1 DNM2 | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.00525543712779 | 0.222222222222 | DNM1 DNM2 | Gap junction degradation |
| REAC:R-HSA-187037 | 0.00548064743149 | 0.333333333333 | DNM1 DNM2 DNM3 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-373760 | 0.00637258740182 | 0.333333333333 | DNM1 DNM2 DNM3 | L1CAM interactions |
| REAC:R-HSA-166520 | 0.00889169623462 | 0.333333333333 | DNM1 DNM2 DNM3 | Signaling by NTRKs |
| REAC:R-HSA-2132295 | 0.00960997261146 | 0.333333333333 | DNM1 DNM2 DNM3 | MHC class II antigen presentation |
| REAC:R-HSA-166016 | 0.0111589919648 | 0.333333333333 | DNM1 DNM2 DNM3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-8856828 | 0.0144087824753 | 0.333333333333 | DNM1 DNM2 DNM3 | Clathrin-mediated endocytosis |
| KEGG:04144 | 0.0154277835769 | 0.333333333333 | DNM1 DNM2 DNM3 | Endocytosis |
| REAC:R-HSA-168898 | 0.0171260552969 | 0.333333333333 | DNM1 DNM2 DNM3 | Toll-like Receptor Cascades |
| REAC:R-HSA-422475 | 0.0305735596836 | 0.444444444444 | DNM3 DNM1 TYROBP DNM2 | Axon guidance |
| REAC:R-HSA-9675108 | 0.0352407247709 | 0.444444444444 | DNM3 DNM1 TYROBP DNM2 | Nervous system development |
| CORUM:1957 | 0.0499842271994 | 0.111111111111 | TYROBP | DAP12 signaling homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DNM2 | DNM3 | 1.0 | 0.896 |
mutually_exclusive (Q05193)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DNM2 | DNM1 | 0.999 | 0.11 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| DNM1 | DNM3 | 0.999 | 0.158 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FAM118A | TYROBP | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TYROBP | PARP14 | 0.988 | 0.128 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPY | TYROBP | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TYROBP | DNM1 | 0.984 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LYPD6 | DNM2 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LYPD6 | DNM3 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TYROBP | DNM2 | 0.968 | 0.0978095238095 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LYPD6 | ELOVL4 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FAM118A | PPY | 0.902 | bioplex3_WMM WMM_only | ||
| LYPD6 | DNM1 | 0.889 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TYROBP | DNM3 | 0.876 | 0.132 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAM118A | DNM1 | 0.696 | 0.06 | bioplex3_WMM WMM_only | |
| FAM118A | PARP14 | 0.654 | 0.048 | bioplex3_WMM WMM_only | |
| PPY | DNM1 | 0.356 | bioplex3_WMM WMM_only | ||
| ELOVL4 | DNM2 | 0.344 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ELOVL4 | DNM3 | 0.268 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PPY | PARP14 | 0.245 | bioplex3_WMM WMM_only | ||
| FAM118A | DNM2 | 0.143 | 0.064 | bioplex3_WMM WMM_only | |
| PARP14 | DNM1 | 0.133 | 0.06 | bioplex3_WMM WMM_only | |
| ELOVL4 | DNM1 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PARP14 | DNM2 | 0.116 | 0.048 | bioplex3_WMM youn_WMM WMM_only | |
| PPY | DNM2 | 0.076 | bioplex3_WMM WMM_only | ||
| FAM118A | DNM3 | 0.056 | 0.122 | bioplex3_WMM WMM_only | |
| PPY | DNM3 | 0.055 | bioplex3_WMM WMM_only | ||
| PARP14 | DNM3 | 0.027 | 0.09 | bioplex3_WMM WMM_only | |
| PARP14 | ELOVL4 | 0.01 | bioplex3_WMM WMM_only |
Related Complexes