hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11128.1
Complex Portal: CPX-24436
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | 5 | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | 5 | UniProt NCBI |
| SEC23IP | SEC23-interacting protein (p125) | 5 | UniProt NCBI |
| C8G | Complement component C8 gamma chain | 5 | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | 5 | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | 5 | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | 5 | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030127 | 8.28185622893e-13 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | COPII vesicle coat |
| GO:0090110 | 8.28185622893e-13 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | COPII-coated vesicle cargo loading |
| WP:WP1982 | 2.05303568287e-11 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | Sterol regulatory element binding proteins SREBP signaling |
| GO:0030134 | 2.30047025184e-11 | 0.875 | SEC23IP SEC23B SEC24C SEC24A SEC24D SEC24B SEC23A | COPII-coated ER to Golgi transport vesicle |
| GO:0070971 | 2.37823880186e-11 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | endoplasmic reticulum exit site |
| REAC:R-HSA-204005 | 2.43069005585e-11 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | COPII-mediated vesicle transport |
| GO:0035459 | 7.60119707806e-11 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | vesicle cargo loading |
| REAC:R-HSA-983170 | 1.72573247338e-10 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 1.72573247338e-10 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Cargo concentration in the ER |
| GO:0090114 | 3.3650917011e-10 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | COPII-coated vesicle budding |
| GO:0012507 | 1.26435323449e-09 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | ER to Golgi transport vesicle membrane |
| KEGG:04141 | 1.82924069262e-09 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | Protein processing in endoplasmic reticulum |
| GO:0030120 | 3.73487864754e-09 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | vesicle coat |
| REAC:R-HSA-1655829 | 4.51136393401e-09 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| REAC:R-HSA-199977 | 4.62987037538e-09 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 1.42265119385e-08 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | Transport to the Golgi and subsequent modification |
| GO:0006900 | 1.60521278412e-08 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | vesicle budding from membrane |
| GO:0048475 | 5.17906168383e-08 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | coated membrane |
| GO:0030117 | 5.17906168383e-08 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | membrane coat |
| GO:0030135 | 6.92261040759e-08 | 0.875 | SEC23IP SEC23B SEC24C SEC24A SEC24D SEC24B SEC23A | coated vesicle |
| CORUM:7141 | 9.81744484776e-08 | 0.375 | SEC23A SEC23IP SEC24B | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| REAC:R-HSA-9705671 | 2.82619489582e-07 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| GO:0030658 | 2.87622749828e-07 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | transport vesicle membrane |
| REAC:R-HSA-446203 | 2.88424081735e-07 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | Asparagine N-linked glycosylation |
| GO:0006888 | 3.36714282431e-07 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-2132295 | 3.52670682859e-07 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | MHC class II antigen presentation |
| REAC:R-HSA-8957322 | 4.35939169188e-07 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Metabolism of steroids |
| GO:0030662 | 1.28703645714e-06 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | coated vesicle membrane |
| REAC:R-HSA-9705683 | 3.85680343092e-06 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | SARS-CoV-2-host interactions |
| REAC:R-HSA-199991 | 1.97177804739e-05 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | Membrane Trafficking |
| CORUM:7139 | 2.39226645298e-05 | 0.25 | SEC23A SEC24B | SEC23-SEC24 adaptor complex |
| REAC:R-HSA-9694516 | 2.4954440538e-05 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | SARS-CoV-2 Infection |
| REAC:R-HSA-5653656 | 2.7250868174e-05 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | Vesicle-mediated transport |
| GO:0030133 | 3.36912170376e-05 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | transport vesicle |
| GO:0048193 | 5.10637938691e-05 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | Golgi vesicle transport |
| KEGG:05130 | 5.24065768505e-05 | 0.5 | SEC24B SEC24D SEC24C SEC24A | Pathogenic Escherichia coli infection |
| GO:0016050 | 6.49465755701e-05 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | vesicle organization |
| REAC:R-HSA-983169 | 8.12062232021e-05 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-9679506 | 0.000122711400125 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | SARS-CoV Infections |
| CORUM:7140 | 0.000143457417375 | 0.25 | SEC23A SEC24B | SEC23-SEC24-SCAP-SREBP1c complex |
| TF:M11235_1 | 0.000886327111509 | 0.375 | SEC23A SEC24A SEC24D | Factor: OASIS; motif: YGCCACGTCANC; match class: 1 |
| REAC:R-HSA-556833 | 0.00135885625735 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Metabolism of lipids |
| GO:0098796 | 0.00148283497143 | 0.875 | C8G SEC23B SEC24C SEC24A SEC24D SEC24B SEC23A | membrane protein complex |
| REAC:R-HSA-597592 | 0.0018209311458 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | Post-translational protein modification |
| REAC:R-HSA-1280218 | 0.00202681801237 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Adaptive Immune System |
| REAC:R-HSA-9824446 | 0.00267983185965 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Viral Infection Pathways |
| GO:0000149 | 0.00366371076373 | 0.5 | SEC24B SEC24D SEC24C SEC24A | SNARE binding |
| GO:0061024 | 0.00426135925956 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | membrane organization |
| GO:0046907 | 0.00445185102023 | 0.875 | SEC23IP SEC23B SEC24C SEC24A SEC24D SEC24B SEC23A | intracellular transport |
| REAC:R-HSA-5663205 | 0.00732097255999 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | Infectious disease |
| GO:0008270 | 0.00779067226317 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | zinc ion binding |
| HP:0002868 | 0.00812142628406 | 0.25 | SEC23A SEC24D | Narrow iliac wing |
| REAC:R-HSA-168256 | 0.0113619114179 | 0.75 | C8G SEC24C SEC24D SEC24A SEC24B SEC23A | Immune System |
| REAC:R-HSA-392499 | 0.0122053588899 | 0.75 | SEC23IP SEC24C SEC24D SEC24A SEC24B SEC23A | Metabolism of proteins |
| GO:0030659 | 0.0231270988724 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | cytoplasmic vesicle membrane |
| GO:0051649 | 0.0250941260125 | 0.875 | SEC23IP SEC23B SEC24C SEC24A SEC24D SEC24B SEC23A | establishment of localization in cell |
| GO:0012506 | 0.0254054411923 | 0.75 | SEC24C SEC24D SEC24A SEC24B SEC23B SEC23A | vesicle membrane |
| GO:0046914 | 0.0416793887279 | 0.625 | SEC23A SEC24D SEC24A SEC24C SEC24B | transition metal ion binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SEC23B | SEC24A | 1.0 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction | |
| SEC23B | SEC24C | 1.0 | 0.268 |
structurally_consistent (O94855)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24C | 1.0 | 0.53 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.106 |
mutually_exclusive (O94855)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24A | 1.0 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | |
| SEC23B | SEC24B | 0.999 | 0.102 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24B | 0.999 | 0.286666666667 |
structurally_consistent (Q15437)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC24B | SEC24A | 0.996 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SEC23A | SEC23IP | 0.995 | 0.254 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| SEC23B | SEC24D | 0.993 | 0.208 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SEC24C | SEC24B | 0.992 | 0.27 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction | |
| SEC24C | SEC24A | 0.991 | 0.386 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | |
| SEC23B | SEC23IP | 0.99 | 0.092 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SEC23A | SEC24D | 0.981 | 0.302631578947 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24A | 0.963 | 0.266 | bioplex_WMM bioplex3_WMM Malo fraction | |
| C8G | SEC24B | 0.963 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SEC23B | C8G | 0.683 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SEC24D | SEC24C | 0.602 | 0.136 |
mutually_exclusive (Q15436)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM Malo fraction |
| SEC23A | C8G | 0.431 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SEC24D | SEC24B | 0.342 | 0.116 | bioplex_WMM bioplex3_WMM fraction | |
| SEC23IP | SEC24B | 0.242 | 0.184 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SEC23IP | SEC24A | 0.124 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SEC24D | SEC23IP | 0.106 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only | |
| SEC23IP | SEC24C | 0.07 | 0.516 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM treiber_WMM | |
| SEC24C | C8G | 0.005 | bioplex3_HEK293 WMM_only |
Related Complexes