hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11130.1
Complex Portal: CPX-16140
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAB3GAP2 | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | 5 | UniProt NCBI |
| GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) | 5 | UniProt NCBI |
| SARS1 | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | 5 | UniProt NCBI |
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | 5 | UniProt NCBI |
| SIRT2 | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0100952 | 0.000641107533884 | 0.4 | RAB3GAP2 RAB3GAP1 | Enlarged sylvian cistern |
| HP:0001302 | 0.00700766042008 | 0.6 | RAB3GAP1 RAB3GAP2 SARS1 | Pachygyria |
| HP:0001339 | 0.010048196591 | 0.6 | RAB3GAP1 RAB3GAP2 SARS1 | Lissencephaly |
| GO:0097051 | 0.0140440992017 | 0.4 | RAB3GAP2 RAB3GAP1 | establishment of protein localization to endoplasmic reticulum membrane |
| HP:0000064 | 0.0176485923371 | 0.4 | RAB3GAP2 RAB3GAP1 | Hypoplastic labia minora |
| REAC:R-HSA-6811436 | 0.0184995798233 | 0.4 | RAB3GAP2 RAB3GAP1 | COPI-independent Golgi-to-ER retrograde traffic |
| HP:0000060 | 0.0207761643339 | 0.4 | RAB3GAP2 RAB3GAP1 | Clitoral hypoplasia |
| HP:0040255 | 0.0207761643339 | 0.4 | RAB3GAP2 RAB3GAP1 | Aplasia/Hypoplasia of the clitoris |
| HP:0009465 | 0.0241576577336 | 0.4 | RAB3GAP2 RAB3GAP1 | Ulnar deviation of finger |
| HP:0012880 | 0.0259435594648 | 0.4 | RAB3GAP2 RAB3GAP1 | Abnormal labia minora morphology |
| GO:0050747 | 0.0280843539964 | 0.4 | RAB3GAP2 RAB3GAP1 | positive regulation of lipoprotein metabolic process |
| GO:1903373 | 0.0280843539964 | 0.4 | RAB3GAP2 RAB3GAP1 | positive regulation of endoplasmic reticulum tubular network organization |
| GO:1903061 | 0.0280843539964 | 0.4 | RAB3GAP2 RAB3GAP1 | positive regulation of protein lipidation |
| HP:0000480 | 0.0425110382594 | 0.4 | RAB3GAP2 RAB3GAP1 | Retinal coloboma |
| HP:0001264 | 0.0448666137641 | 0.4 | RAB3GAP2 RAB3GAP1 | Spastic diplegia |
| HP:0000221 | 0.0448666137641 | 0.4 | RAB3GAP2 RAB3GAP1 | Furrowed tongue |
| HP:0009738 | 0.0472853555832 | 0.4 | RAB3GAP2 RAB3GAP1 | Abnormal antihelix morphology |
| REAC:R-HSA-8876198 | 0.0487218825663 | 0.4 | RAB3GAP2 RAB3GAP1 | RAB GEFs exchange GTP for GDP on RABs |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAB3GAP2 | RAB3GAP1 | 0.999 | 0.936 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| SARS1 | SIRT2 | 0.994 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| RAB3GAP2 | SIRT2 | 0.967 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| RAB3GAP1 | SIRT2 | 0.967 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| GPAM | SIRT2 | 0.966 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SARS1 | GPAM | 0.246 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAB3GAP2 | GPAM | 0.216 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAB3GAP1 | GPAM | 0.184 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| SARS1 | RAB3GAP1 | 0.116 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only | |
| SARS1 | RAB3GAP2 | 0.077 | 0.246 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes