hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11137.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DNM1 | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | 5 | UniProt NCBI |
| LYPD6 | Ly6/PLAUR domain-containing protein 6 | 5 | UniProt NCBI |
| ELOVL4 | Very long chain fatty acid elongase 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Elongation of very long chain fatty acids protein 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) | 5 | UniProt NCBI |
| DNM2 | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | 5 | UniProt NCBI |
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 6.85937538545e-07 | 0.6 | DNM3 DNM1 DNM2 | Retrograde neurotrophin signalling |
| WP:WP2267 | 1.48411025729e-05 | 0.6 | DNM3 DNM1 DNM2 | Synaptic vesicle pathway |
| KEGG:04961 | 1.50636395604e-05 | 0.6 | DNM3 DNM1 DNM2 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04721 | 3.17476783734e-05 | 0.6 | DNM3 DNM1 DNM2 | Synaptic vesicle cycle |
| REAC:R-HSA-437239 | 4.71645743242e-05 | 0.6 | DNM3 DNM1 DNM2 | Recycling pathway of L1 |
| KEGG:05100 | 6.51136022216e-05 | 0.6 | DNM3 DNM1 DNM2 | Bacterial invasion of epithelial cells |
| KEGG:04072 | 0.000233794609807 | 0.6 | DNM3 DNM1 DNM2 | Phospholipase D signaling pathway |
| REAC:R-HSA-187037 | 0.000455699137987 | 0.6 | DNM3 DNM1 DNM2 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-373760 | 0.00053040697399 | 0.6 | DNM3 DNM1 DNM2 | L1CAM interactions |
| REAC:R-HSA-166520 | 0.00074191010701 | 0.6 | DNM3 DNM1 DNM2 | Signaling by NTRKs |
| REAC:R-HSA-2132295 | 0.000802337674321 | 0.6 | DNM3 DNM1 DNM2 | MHC class II antigen presentation |
| REAC:R-HSA-196025 | 0.000835043279679 | 0.4 | DNM1 DNM2 | Formation of annular gap junctions |
| REAC:R-HSA-166016 | 0.000932817738425 | 0.6 | DNM3 DNM1 DNM2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-190873 | 0.00100191474811 | 0.4 | DNM1 DNM2 | Gap junction degradation |
| REAC:R-HSA-8856828 | 0.00120721178545 | 0.6 | DNM3 DNM1 DNM2 | Clathrin-mediated endocytosis |
| REAC:R-HSA-168898 | 0.00143724099843 | 0.6 | DNM3 DNM1 DNM2 | Toll-like Receptor Cascades |
| KEGG:04144 | 0.00184833104877 | 0.6 | DNM3 DNM1 DNM2 | Endocytosis |
| REAC:R-HSA-190828 | 0.0112072433688 | 0.4 | DNM1 DNM2 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.0117954816348 | 0.4 | DNM1 DNM2 | Gap junction trafficking and regulation |
| GO:0140238 | 0.0135806930791 | 0.6 | DNM3 DNM1 DNM2 | presynaptic endocytosis |
| GO:0048488 | 0.0135806930791 | 0.6 | DNM3 DNM1 DNM2 | synaptic vesicle endocytosis |
| GO:0036465 | 0.0237169649094 | 0.6 | DNM3 DNM1 DNM2 | synaptic vesicle recycling |
| WP:WP4549 | 0.0347437372246 | 0.4 | DNM1 DNM2 | Fragile X syndrome |
| REAC:R-HSA-9006934 | 0.0398305153279 | 0.6 | DNM3 DNM1 DNM2 | Signaling by Receptor Tyrosine Kinases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DNM2 | DNM3 | 1.0 | 0.896 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DNM2 | DNM1 | 0.999 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| DNM1 | DNM3 | 0.999 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LYPD6 | DNM2 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LYPD6 | DNM3 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LYPD6 | ELOVL4 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LYPD6 | DNM1 | 0.889 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ELOVL4 | DNM2 | 0.344 | bioplex_WMM bioplex3_WMM WMM_only | |
| ELOVL4 | DNM3 | 0.268 | bioplex_WMM bioplex3_WMM WMM_only | |
| ELOVL4 | DNM1 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes