hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11148.1

Complex Portal: CPX-18602

Confidence: Medium High

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Genename	Protein Name	Uniprot Annotation Score	Links
CHRM4	Muscarinic acetylcholine receptor M4	5	UniProt NCBI
ETF1	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)	5	UniProt NCBI
GSPT1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)	5	UniProt NCBI
GSPT2	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog)	5	UniProt NCBI
IREB2	Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)	5	UniProt NCBI
MKRN2	E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)	5	UniProt NCBI
MKRN3	Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)	5	UniProt NCBI
PABPC1L	Polyadenylate-binding protein 1-like	3	UniProt NCBI
PABPC5	Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5)	3	UniProt NCBI

Showing 1 to 9 of 9 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03015	4.78181952093e-06	0.5	ETF1 PABPC1L PABPC5 GSPT2	mRNA surveillance pathway
GO:0003723	0.026768592614	0.875	GSPT2 MKRN2 PABPC1L ETF1 PABPC5 MKRN3 IREB2	RNA binding
WP:WP107	0.0277732439303	0.25	ETF1 GSPT2	Translation factors
KEGG:03018	0.0334539586856	0.25	PABPC5 PABPC1L	RNA degradation
GO:0018444	0.0393180950424	0.25	ETF1 GSPT2	translation release factor complex
CORUM:809	0.0499436884912	0.125	ETF1	eRF1-eRF3-GTP-Mg(2+) complex

Showing 1 to 6 of 6 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
GSPT2	GSPT1	0.999	0.898	mutually_exclusive (P62495)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
MKRN3	PABPC5	0.995	0.072		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSPT2	MKRN3	0.994	0.064		bioplex3_WMM bioplex3_HCT116 WMM_only
IREB2	PABPC5	0.99	0.062	structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
GSPT2	IREB2	0.99	0.038		bioplex3_WMM bioplex3_HCT116 WMM_only
GSPT2	ETF1	0.987	0.686	structurally_consistent (dimer)	youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
ETF1	GSPT1	0.983	0.648	structurally_consistent (dimer)	hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
MKRN2	GSPT2	0.983	0.168		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
GSPT1	CHRM4	0.955			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MKRN2	IREB2	0.854	0.06		bioplex_WMM bioplex3_WMM WMM_only

Showing 1 to 10 of 21 entries

Related Complexes

Genename	Complexes
PABPC5	huMAP3_06111.1 huMAP3_09113.1 huMAP3_10114.1 huMAP3_10424.1 huMAP3_10731.1 huMAP3_11148.1 huMAP3_11768.1
ETF1	huMAP3_00990.1 huMAP3_03127.1 huMAP3_03894.1 huMAP3_04700.1 huMAP3_05833.1 huMAP3_05874.1 huMAP3_05899.1 huMAP3_06070.1 huMAP3_07661.1 huMAP3_10114.1 huMAP3_10349.1 huMAP3_10628.1 huMAP3_10914.1 huMAP3_11148.1 huMAP3_14442.1
MKRN3	huMAP3_05874.1 huMAP3_05899.1 huMAP3_07661.1 huMAP3_08105.1 huMAP3_08748.1 huMAP3_09113.1 huMAP3_09186.1 huMAP3_09706.1 huMAP3_10114.1 huMAP3_10625.1 huMAP3_11047.1 huMAP3_11148.1
MKRN2	huMAP3_00714.1 huMAP3_00797.1 huMAP3_03127.1 huMAP3_03962.1 huMAP3_05252.1 huMAP3_05293.1 huMAP3_05560.1 huMAP3_05705.1 huMAP3_05745.1 huMAP3_05874.1 huMAP3_05899.1 huMAP3_06070.1 huMAP3_07375.1 huMAP3_07661.1 huMAP3_07973.1 huMAP3_08105.1 huMAP3_09142.1 huMAP3_09186.1 huMAP3_09376.1 huMAP3_09706.1 huMAP3_10114.1 huMAP3_10625.1 huMAP3_10628.1 huMAP3_11047.1 huMAP3_11073.1 huMAP3_11148.1
IREB2	huMAP3_00797.1 huMAP3_05874.1 huMAP3_05899.1 huMAP3_06111.1 huMAP3_09330.1 huMAP3_09454.1 huMAP3_10114.1 huMAP3_10424.1 huMAP3_10628.1 huMAP3_10731.1 huMAP3_11148.1 huMAP3_11768.1
CHRM4	huMAP3_04409.1 huMAP3_10114.1 huMAP3_10628.1 huMAP3_11148.1 huMAP3_14978.1
GSPT1	huMAP3_03894.1 huMAP3_04409.1 huMAP3_10114.1 huMAP3_10628.1 huMAP3_11148.1 huMAP3_14192.1 huMAP3_14978.1
GSPT2	huMAP3_00797.1 huMAP3_03127.1 huMAP3_04700.1 huMAP3_05252.1 huMAP3_05293.1 huMAP3_05745.1 huMAP3_05874.1 huMAP3_05899.1 huMAP3_06070.1 huMAP3_06975.1 huMAP3_07661.1 huMAP3_07893.1 huMAP3_08748.1 huMAP3_09142.1 huMAP3_09186.1 huMAP3_09376.1 huMAP3_10114.1 huMAP3_10625.1 huMAP3_10628.1 huMAP3_11047.1 huMAP3_11073.1 huMAP3_11148.1 huMAP3_14192.1
PABPC1L	huMAP3_00714.1 huMAP3_00797.1 huMAP3_01334.1 huMAP3_03127.1 huMAP3_03962.1 huMAP3_05293.1 huMAP3_05560.1 huMAP3_05705.1 huMAP3_05745.1 huMAP3_05874.1 huMAP3_05899.1 huMAP3_06070.1 huMAP3_07375.1 huMAP3_07661.1 huMAP3_07893.1 huMAP3_07973.1 huMAP3_08105.1 huMAP3_09142.1 huMAP3_09186.1 huMAP3_09376.1 huMAP3_09706.1 huMAP3_10114.1 huMAP3_10625.1 huMAP3_10628.1 huMAP3_11047.1 huMAP3_11073.1 huMAP3_11148.1