hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11148.1
Complex Portal: CPX-18602
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PABPC5 | Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5) | 3 | UniProt NCBI |
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt NCBI |
| MKRN3 | Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) | 5 | UniProt NCBI |
| MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt NCBI |
| IREB2 | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | 5 | UniProt NCBI |
| CHRM4 | Muscarinic acetylcholine receptor M4 | 5 | UniProt NCBI |
| GSPT1 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) | 5 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
| PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 4.78181952093e-06 | 0.5 | PABPC1L GSPT2 PABPC5 ETF1 | mRNA surveillance pathway |
| GO:0003723 | 0.026768592614 | 0.875 | PABPC5 GSPT2 PABPC1L ETF1 MKRN3 MKRN2 IREB2 | RNA binding |
| WP:WP107 | 0.0277732439303 | 0.25 | GSPT2 ETF1 | Translation factors |
| KEGG:03018 | 0.0334539586856 | 0.25 | PABPC5 PABPC1L | RNA degradation |
| GO:0018444 | 0.0393180950424 | 0.25 | GSPT2 ETF1 | translation release factor complex |
| CORUM:809 | 0.0499436884912 | 0.125 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GSPT2 | GSPT1 | 0.999 | 0.898 |
mutually_exclusive (P62495)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| MKRN3 | PABPC5 | 0.995 | 0.072 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GSPT2 | MKRN3 | 0.994 | 0.064 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IREB2 | PABPC5 | 0.99 | 0.062 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| GSPT2 | IREB2 | 0.99 | 0.038 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GSPT2 | ETF1 | 0.987 | 0.686 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ETF1 | GSPT1 | 0.983 | 0.648 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| MKRN2 | GSPT2 | 0.983 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| GSPT1 | CHRM4 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MKRN2 | IREB2 | 0.854 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKRN2 | PABPC5 | 0.717 | 0.13 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MKRN2 | MKRN3 | 0.561 | 0.134 | bioplex3_WMM WMM_only | |
| MKRN2 | GSPT1 | 0.524 | 0.178 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| GSPT1 | MKRN3 | 0.388 | 0.082 | bioplex3_WMM WMM_only | |
| IREB2 | GSPT1 | 0.356 | 0.064 | bioplex3_WMM WMM_only | |
| IREB2 | MKRN3 | 0.346 | 0.1 | bioplex3_WMM WMM_only | |
| ETF1 | PABPC5 | 0.044 | 0.274 | bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| MKRN2 | ETF1 | 0.025 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| GSPT1 | PABPC5 | 0.008 | 0.26 | gupta_WMM WMM_only | |
| IREB2 | ETF1 | 0.006 | 0.086 | bioplex3_WMM WMM_only | |
| ETF1 | MKRN3 | 0.006 | 0.038 | bioplex3_WMM WMM_only |
Related Complexes