hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11149.1

Complex Portal: CPX-13365

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
CX3CL1	Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]	5	UniProt NCBI
LRP10	Low-density lipoprotein receptor-related protein 10 (LRP-10)	5	UniProt NCBI
LAPTM4B	Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta)	5	UniProt NCBI
IFNGR1	Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)	5	UniProt NCBI
RELT	Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues)	5	UniProt NCBI
BMPR1A	Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)	5	UniProt NCBI
JAK1	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)	5	UniProt NCBI
TMEM204	Transmembrane protein 204 (Claudin-like protein 24)	4	UniProt NCBI
PTPRS	Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)	5	UniProt NCBI
CSNK1G1	Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1)	5	UniProt NCBI
NDFIP1	NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)	5	UniProt NCBI
ACVR2B	Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)	5	UniProt NCBI
ACVR2A	Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)	5	UniProt NCBI
TNFRSF10B	Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)	5	UniProt NCBI
RNF133	E3 ubiquitin-protein ligase RNF133 (EC 2.3.2.27) (RING finger protein 133) (RING-type E3 ubiquitin transferase RNF133)	5	UniProt NCBI
PTPRF	Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)	5	UniProt NCBI
UGCG	Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)	5	UniProt NCBI
CSNK1G2	Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)	5	UniProt NCBI
SYT11	Synaptotagmin-11 (Synaptotagmin XI) (SytXI)	5	UniProt NCBI
CASP8	Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	5	UniProt NCBI
EPHA2	Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)	5	UniProt NCBI
CFLAR	CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]	5	UniProt NCBI
KCNE4	Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3)	5	UniProt NCBI
ACVR1B	Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)	5	UniProt NCBI
OSMR	Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)	5	UniProt NCBI
IL20RB	Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2)	5	UniProt NCBI
TGFBR2	TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)	5	UniProt NCBI
RNF149	E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)	5	UniProt NCBI
TNFRSF10A	Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)	5	UniProt NCBI
PLEKHH3	Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3)	3	UniProt NCBI
FADD	FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)	5	UniProt NCBI
PTPRD	Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04060	1.43125064215e-12	0.407407407407	ACVR2A TNFRSF10B TNFRSF10A BMPR1A IL20RB RELT TGFBR2 CX3CL1 ACVR1B ACVR2B OSMR	Cytokine-cytokine receptor interaction
REAC:R-HSA-75158	9.88774417147e-11	0.185185185185	FADD TNFRSF10B TNFRSF10A CFLAR CASP8	TRAIL signaling
CORUM:5798	4.59397255145e-07	0.111111111111	CASP8 CFLAR FADD	Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced
CORUM:5799	4.59397255145e-07	0.111111111111	CASP8 CFLAR FADD	DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced
REAC:R-HSA-5218900	6.24965952167e-07	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	CASP8 activity is inhibited
REAC:R-HSA-69416	6.24965952167e-07	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Dimerization of procaspase-8
REAC:R-HSA-3371378	6.24965952167e-07	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Regulation by c-FLIP
GO:0004675	1.43894791801e-06	0.185185185185	TGFBR2 ACVR1B ACVR2A BMPR1A ACVR2B	transmembrane receptor protein serine/threonine kinase activity
REAC:R-HSA-140534	2.11983113355e-06	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Caspase activation via Death Receptors in the presence of ligand
REAC:R-HSA-5357769	1.1404999021e-05	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Caspase activation via extrinsic apoptotic signalling pathway
GO:0048185	1.61015485331e-05	0.148148148148	TGFBR2 ACVR1B ACVR2B ACVR2A	activin binding
GO:0007166	1.86606229817e-05	0.62962962963	TNFRSF10A ACVR2A CASP8 FADD TMEM204 CSNK1G2 BMPR1A CSNK1G1 IL20RB UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B ACVR2B TGFBR2 OSMR	cell surface receptor signaling pathway
KEGG:04350	3.18391077914e-05	0.185185185185	TGFBR2 ACVR1B ACVR2A BMPR1A ACVR2B	TGF-beta signaling pathway
GO:0017002	3.21625423531e-05	0.148148148148	TGFBR2 ACVR1B ACVR2B ACVR2A	activin receptor activity
GO:0036462	3.21625423531e-05	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	TRAIL-activated apoptotic signaling pathway
WP:WP1772	3.59923412907e-05	0.185185185185	FADD TNFRSF10B TNFRSF10A CFLAR CASP8	Apoptosis modulation and signaling
REAC:R-HSA-5213460	7.95281515499e-05	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	RIPK1-mediated regulated necrosis
REAC:R-HSA-5675482	7.95281515499e-05	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Regulation of necroptotic cell death
REAC:R-HSA-1433617	0.000152225242636	0.111111111111	ACVR1B ACVR2B ACVR2A	Regulation of signaling by NODAL
KEGG:04210	0.000157538430003	0.185185185185	FADD TNFRSF10B TNFRSF10A CFLAR CASP8	Apoptosis
REAC:R-HSA-1502540	0.000217196789786	0.111111111111	ACVR1B ACVR2B ACVR2A	Signaling by Activin
KEGG:04061	0.00024051583928	0.148148148148	CX3CL1 TNFRSF10A IL20RB TNFRSF10B	Viral protein interaction with cytokine and cytokine receptor
CORUM:5991	0.000268526883577	0.0740740740741	CASP8 FADD	LRRK2-FADD-CASP8 complex
CORUM:5473	0.000268526883577	0.0740740740741	CASP8 FADD	DISC complex (FAS, FADD, CASP8)
CORUM:5800	0.000268526883577	0.0740740740741	CASP8 FADD	DISC complex (FAS, FADD, CASP8)
CORUM:5808	0.000268526883577	0.0740740740741	CASP8 FADD	DISC complex (CD95, FADD, CASP8)
CORUM:5859	0.000268526883577	0.0740740740741	CASP8 FADD	FAS-FADD-CASP8-CASP10 complex
CORUM:5860	0.000268526883577	0.0740740740741	CASP8 FADD	DISC complex (FAS, FADD, CASP8)
KEGG:04217	0.000302264210832	0.185185185185	FADD TNFRSF10B TNFRSF10A CFLAR CASP8	Necroptosis
GO:0009967	0.000441747690315	0.481481481481	NDFIP1 ACVR2A CASP8 FADD TNFRSF10B CSNK1G2 BMPR1A CSNK1G1 TGFBR2 CFLAR CX3CL1 ACVR1B ACVR2B	positive regulation of signal transduction
REAC:R-HSA-9006936	0.000462265911628	0.185185185185	TGFBR2 ACVR1B ACVR2A BMPR1A ACVR2B	Signaling by TGFB family members
GO:0048584	0.000555332053973	0.555555555556	NDFIP1 PTPRS CASP8 FADD TNFRSF10B CSNK1G2 BMPR1A CSNK1G1 OSMR TGFBR2 CFLAR CX3CL1 ACVR1B ACVR2B ACVR2A	positive regulation of response to stimulus
GO:0005886	0.000645150472054	0.740740740741	TNFRSF10A PTPRS SYT11 CSNK1G2 TMEM204 ACVR2B LRP10 CSNK1G1 FADD OSMR IL20RB LAPTM4B TNFRSF10B CX3CL1 ACVR1B CASP8 TGFBR2 BMPR1A CFLAR ACVR2A	plasma membrane
WP:WP2507	0.000686674036601	0.111111111111	CASP8 CFLAR FADD	Nanomaterial induced apoptosis
CORUM:6414	0.000804661856221	0.0740740740741	CASP8 FADD	RIPK1-FADD-caspase-8 complex
CORUM:5749	0.000804661856221	0.0740740740741	CASP8 CFLAR	MRIT complex
REAC:R-HSA-5218859	0.000825487125838	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Regulated Necrosis
REAC:R-HSA-73887	0.00102939094396	0.185185185185	FADD TNFRSF10B TNFRSF10A CFLAR CASP8	Death Receptor Signaling
WP:WP254	0.00118447549971	0.148148148148	FADD TNFRSF10B CFLAR CASP8	Apoptosis
GO:0010647	0.00123758419327	0.481481481481	NDFIP1 ACVR2A CASP8 FADD TNFRSF10B CSNK1G2 BMPR1A CSNK1G1 TGFBR2 CFLAR CX3CL1 ACVR1B ACVR2B	positive regulation of cell communication
KEGG:05142	0.00127287978996	0.148148148148	FADD CASP8 CFLAR TGFBR2	Chagas disease
GO:0023056	0.00130459227377	0.481481481481	NDFIP1 ACVR2A CASP8 FADD TNFRSF10B CSNK1G2 BMPR1A CSNK1G1 TGFBR2 CFLAR CX3CL1 ACVR1B ACVR2B	positive regulation of signaling
GO:0023051	0.00134010132343	0.62962962963	NDFIP1 PTPRS SYT11 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B CASP8 BMPR1A TGFBR2 ACVR2A	regulation of signaling
GO:0010646	0.00136775397847	0.62962962963	NDFIP1 PTPRS SYT11 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B CASP8 BMPR1A TGFBR2 ACVR2A	regulation of cell communication
GO:0098797	0.00138554799513	0.333333333333	ACVR2A FADD TGFBR2 CFLAR BMPR1A CASP8 ACVR2B ACVR1B OSMR	plasma membrane protein complex
REAC:R-HSA-1181150	0.00146244986786	0.111111111111	ACVR1B ACVR2B ACVR2A	Signaling by NODAL
CORUM:2054	0.00160748838708	0.0740740740741	CASP8 FADD	CASP8-FADD-MALT1-BCL10 complex
KEGG:04668	0.00172249640808	0.148148148148	FADD CX3CL1 CFLAR CASP8	TNF signaling pathway
GO:0008625	0.00216165433206	0.185185185185	FADD TNFRSF10B TNFRSF10A CFLAR CASP8	extrinsic apoptotic signaling pathway via death domain receptors
GO:0048583	0.00255512561781	0.666666666667	NDFIP1 PTPRS SYT11 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 OSMR UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B CASP8 BMPR1A TGFBR2 ACVR2A	regulation of response to stimulus
GO:0048179	0.00280458876292	0.111111111111	ACVR1B ACVR2B ACVR2A	activin receptor complex
GO:0097342	0.00280458876292	0.111111111111	CASP8 CFLAR FADD	ripoptosome
GO:0032927	0.00280458876292	0.111111111111	ACVR1B ACVR2B ACVR2A	positive regulation of activin receptor signaling pathway
GO:0009966	0.00308333986264	0.592592592593	NDFIP1 PTPRS CASP8 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B BMPR1A TGFBR2 ACVR2A	regulation of signal transduction
GO:0071944	0.00373832271359	0.740740740741	TNFRSF10A PTPRS SYT11 CSNK1G2 TMEM204 ACVR2B LRP10 CSNK1G1 FADD OSMR IL20RB LAPTM4B TNFRSF10B CX3CL1 ACVR1B CASP8 TGFBR2 BMPR1A CFLAR ACVR2A	cell periphery
WP:WP5322	0.00396447460779	0.148148148148	TNFRSF10B TNFRSF10A TGFBR2 CASP8	CKAP4 signaling pathway map
REAC:R-HSA-201451	0.00408670502449	0.111111111111	ACVR2A BMPR1A ACVR2B	Signaling by BMP
KEGG:04550	0.00430671336847	0.148148148148	ACVR1B ACVR2A BMPR1A ACVR2B	Signaling pathways regulating pluripotency of stem cells
GO:0098802	0.00534860500756	0.222222222222	OSMR TGFBR2 ACVR2B BMPR1A ACVR1B ACVR2A	plasma membrane signaling receptor complex
GO:0019199	0.00556830173555	0.185185185185	TGFBR2 ACVR1B ACVR2A BMPR1A ACVR2B	transmembrane receptor protein kinase activity
WP:WP314	0.00583981958834	0.111111111111	CASP8 CFLAR FADD	Fas ligand pathway and stress induction of heat shock proteins
GO:0090100	0.00601714965435	0.185185185185	TGFBR2 ACVR1B ACVR2A BMPR1A ACVR2B	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
REAC:R-HSA-75157	0.00638820060321	0.0740740740741	CASP8 FADD	FasL/ CD95L signaling
REAC:R-HSA-162582	0.00645639074602	0.481481481481	TNFRSF10A ACVR2A FADD TNFRSF10B CSNK1G2 BMPR1A CASP8 TGFBR2 CFLAR CX3CL1 ACVR1B ACVR2B PTPRS	Signal Transduction
KEGG:05164	0.00873809090818	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Influenza A
GO:0097191	0.00946659743278	0.222222222222	CASP8 TNFRSF10B TNFRSF10A CFLAR FADD ACVR1B	extrinsic apoptotic signaling pathway
GO:0031264	0.00979189312029	0.111111111111	CASP8 CFLAR FADD	death-inducing signaling complex
GO:0004888	0.0105579722954	0.333333333333	OSMR TNFRSF10B ACVR2B BMPR1A IL20RB TGFBR2 TNFRSF10A ACVR1B ACVR2A	transmembrane signaling receptor activity
KEGG:04115	0.0142787177517	0.111111111111	TNFRSF10B TNFRSF10A CASP8	p53 signaling pathway
KEGG:05130	0.0147483613222	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Pathogenic Escherichia coli infection
REAC:R-HSA-9013957	0.0159341007103	0.0740740740741	CASP8 FADD	TLR3-mediated TICAM1-dependent programmed cell death
REAC:R-HSA-9693928	0.0159341007103	0.0740740740741	CASP8 FADD	Defective RIPK1-mediated regulated necrosis
GO:0023052	0.0173932681333	0.740740740741	NDFIP1 TNFRSF10A PTPRS SYT11 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 OSMR IL20RB UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B CASP8 BMPR1A TGFBR2 ACVR2A	signaling
GO:0007154	0.0216097483177	0.740740740741	NDFIP1 TNFRSF10A PTPRS SYT11 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 OSMR IL20RB UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B CASP8 BMPR1A TGFBR2 ACVR2A	cell communication
GO:0043123	0.022181748624	0.222222222222	NDFIP1 CASP8 TNFRSF10B CFLAR FADD CX3CL1	positive regulation of canonical NF-kappaB signal transduction
REAC:R-HSA-2562578	0.0222823075059	0.0740740740741	CASP8 FADD	TRIF-mediated programmed cell death
WP:WP2513	0.0275663620667	0.0740740740741	CASP8 FADD	Nanoparticle triggered regulated necrosis
GO:0071260	0.0292563704597	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	cellular response to mechanical stimulus
GO:0007165	0.0334945303541	0.703703703704	NDFIP1 TNFRSF10A PTPRS CASP8 FADD TMEM204 CSNK1G2 ACVR2B CSNK1G1 OSMR IL20RB UGCG TNFRSF10B CFLAR CX3CL1 ACVR1B BMPR1A TGFBR2 ACVR2A	signal transduction
WP:WP4674	0.0364302394776	0.111111111111	FADD CASP8 TGFBR2	Head and neck squamous cell carcinoma
WP:WP5182	0.0379215992938	0.0740740740741	CASP8 FADD	Pro survival signaling of neuroprotectin D1
WP:WP3874	0.0437058414686	0.0740740740741	TGFBR2 BMPR1A	Canonical and non canonical TGF B signaling
KEGG:05132	0.0469579753518	0.148148148148	FADD TNFRSF10B TNFRSF10A CASP8	Salmonella infection

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ACVR2B	ACVR2A	0.999		mutually_exclusive (P36896)
TNFRSF10B	LRP10	0.998	0.236
CSNK1G1	CSNK1G2	0.998	0.09
FADD	CASP8	0.997
RNF133	UGCG	0.996
TGFBR2	BMPR1A	0.996	0.13
RELT	LRP10	0.996
TGFBR2	ACVR2A	0.996		mutually_exclusive (P36896)
TGFBR2	PTPRF	0.995	0.09
PLEKHH3	TGFBR2	0.995	0.11
LRP10	BMPR1A	0.995	0.296
NDFIP1	UGCG	0.995	0.078
ACVR2B	ACVR1B	0.994		structurally_consistent (dimer)
RNF133	LAPTM4B	0.993
TNFRSF10B	BMPR1A	0.993	0.156
TNFRSF10B	JAK1	0.992	0.13
PTPRS	KCNE4	0.991
TNFRSF10B	UGCG	0.991	0.18
JAK1	IFNGR1	0.99	0.182
CASP8	CFLAR	0.99
TNFRSF10B	TGFBR2	0.989	0.2
RELT	RNF149	0.988
LRP10	JAK1	0.988	0.206
NDFIP1	RNF149	0.987	0.21
PTPRS	IL20RB	0.987
TNFRSF10B	RNF149	0.987	0.222
CSNK1G2	KCNE4	0.987
CSNK1G2	ACVR1B	0.987	0.162
ACVR2B	PLEKHH3	0.987
TNFRSF10B	TNFRSF10A	0.986	0.102
ACVR2B	BMPR1A	0.986		structurally_consistent (dimer)
LRP10	UGCG	0.986	0.186
CSNK1G2	LRP10	0.985	0.166
LRP10	TNFRSF10A	0.985	0.178
RELT	JAK1	0.984
TNFRSF10B	FADD	0.983	0.07	structurally_consistent (dimer)
BMPR1A	KCNE4	0.983
OSMR	IL20RB	0.983		mutually_exclusive (P23458)
OSMR	KCNE4	0.983
JAK1	RNF149	0.983	0.242
TGFBR2	LRP10	0.982	0.242
NDFIP1	KCNE4	0.982
NDFIP1	IFNGR1	0.981	0.158
TGFBR2	TNFRSF10A	0.98	0.132
TNFRSF10B	NDFIP1	0.98	0.116
PTPRS	SYT11	0.98	0.07
ACVR2B	PTPRF	0.98
TGFBR2	RELT	0.98
ACVR2A	RNF149	0.979
IL20RB	BMPR1A	0.979
LRP10	KCNE4	0.979
LRP10	IL20RB	0.979
TGFBR2	OSMR	0.979	0.17
CSNK1G2	PTPRS	0.979	0.052
PTPRF	RNF149	0.979	0.06
CX3CL1	IFNGR1	0.978
TNFRSF10B	CASP8	0.978
TNFRSF10B	IFNGR1	0.978	0.126571428571
BMPR1A	IFNGR1	0.977	0.136
NDFIP1	ACVR2A	0.976
LRP10	RNF149	0.976	0.25
BMPR1A	JAK1	0.976	0.112
TGFBR2	JAK1	0.976	0.278
CSNK1G2	EPHA2	0.975	0.112
TNFRSF10B	ACVR2A	0.973
PTPRD	TGFBR2	0.972	0.094
PTPRS	RNF149	0.972	0.078
OSMR	SYT11	0.972	0.094	mutually_exclusive (P23458)
TMEM204	OSMR	0.972
TNFRSF10B	PTPRF	0.971	0.084
TNFRSF10B	LAPTM4B	0.97	0.108
JAK1	ACVR2A	0.97
LRP10	SYT11	0.97	0.13
RNF133	BMPR1A	0.969
ACVR1B	TNFRSF10A	0.969	0.138
PTPRD	RELT	0.968
RELT	ACVR2A	0.967
TNFRSF10A	CASP8	0.967
CSNK1G2	ACVR2B	0.967
UGCG	LAPTM4B	0.966	0.092
ACVR1B	RNF149	0.966	0.182
TMEM204	BMPR1A	0.966
FADD	TNFRSF10A	0.966	0.122
ACVR2B	TGFBR2	0.966		mutually_exclusive (P36896)
PTPRF	UGCG	0.965	0.102
BMPR1A	RNF149	0.965	0.196111111111
PLEKHH3	BMPR1A	0.965	0.082
BMPR1A	ACVR2A	0.964
ACVR2B	EPHA2	0.964
CSNK1G1	RNF149	0.964	0.164
TNFRSF10B	KCNE4	0.963
TNFRSF10B	SYT11	0.963	0.066
TNFRSF10B	IL20RB	0.963
ACVR1B	PTPRF	0.963	0.112
PTPRS	ACVR2A	0.961
TNFRSF10B	CSNK1G2	0.96	0.104	structurally_consistent (dimer)
BMPR1A	UGCG	0.96	0.104
EPHA2	BMPR1A	0.959	0.174
RNF133	LRP10	0.957
RNF149	IFNGR1	0.957	0.258
CSNK1G2	TNFRSF10A	0.957	0.134
CSNK1G2	RNF149	0.956	0.142
CX3CL1	LAPTM4B	0.956
RELT	OSMR	0.955
ACVR1B	ACVR2A	0.955		structurally_consistent (dimer)
IFNGR1	UGCG	0.953	0.166
TNFRSF10A	UGCG	0.953	0.122
RNF133	OSMR	0.952
LRP10	PTPRS	0.952	0.102
TNFRSF10B	PTPRS	0.951	0.084
TNFRSF10B	ACVR1B	0.948	0.154
LRP10	ACVR2A	0.944
PTPRS	BMPR1A	0.944	0.088
PTPRF	ACVR2A	0.943
RELT	PTPRF	0.94
EPHA2	ACVR2A	0.937
LRP10	IFNGR1	0.936	0.238
NDFIP1	PTPRS	0.936	0.068
LRP10	EPHA2	0.935	0.26
ACVR2B	JAK1	0.932
JAK1	SYT11	0.929	0.186	structurally_consistent (dimer)
IL20RB	JAK1	0.929		structurally_consistent (dimer)
PTPRS	IFNGR1	0.928	0.194
PLEKHH3	RNF149	0.927	0.072
OSMR	BMPR1A	0.927	0.168
IFNGR1	LAPTM4B	0.925	0.112
TNFRSF10A	IFNGR1	0.924	0.128
PTPRF	JAK1	0.921	0.09
PTPRS	EPHA2	0.919	0.194
TGFBR2	NDFIP1	0.919	0.098
TGFBR2	PTPRS	0.918	0.1
TNFRSF10B	RELT	0.917
ACVR1B	JAK1	0.917	0.074
TNFRSF10A	BMPR1A	0.912	0.152
RNF133	IFNGR1	0.909
RELT	ACVR1B	0.908
LRP10	OSMR	0.905	0.148
TGFBR2	ACVR1B	0.904	0.188	structurally_consistent (dimer)
RELT	BMPR1A	0.904		structurally_consistent (A8MVW5)
TNFRSF10A	RNF149	0.901	0.196
PLEKHH3	ACVR2A	0.9
NDFIP1	TNFRSF10A	0.899	0.084
TGFBR2	RNF149	0.896	0.238
RELT	TNFRSF10A	0.895
PTPRF	BMPR1A	0.891	0.122
ACVR1B	UGCG	0.888	0.138
LRP10	PTPRF	0.886	0.102
PTPRF	KCNE4	0.885
PLEKHH3	JAK1	0.88	0.15
PTPRS	UGCG	0.88	0.092
PTPRF	SYT11	0.88	0.1
EPHA2	RNF149	0.879	0.198
ACVR2B	LRP10	0.878
CSNK1G2	PTPRF	0.876	0.074
TNFRSF10A	PTPRF	0.875	0.106
PTPRD	PTPRF	0.873	0.052
NDFIP1	BMPR1A	0.872	0.102
TNFRSF10A	JAK1	0.859	0.152
TNFRSF10B	ACVR2B	0.856
RELT	NDFIP1	0.855
PTPRD	TNFRSF10A	0.853	0.112
ACVR1B	SYT11	0.851	0.102
ACVR2B	RNF149	0.846
CSNK1G2	NDFIP1	0.844	0.072
PLEKHH3	NDFIP1	0.839	0.06
ACVR1B	BMPR1A	0.837	0.186	mutually_exclusive (Q13705)
RELT	EPHA2	0.835
ACVR1B	KCNE4	0.835
LRP10	LAPTM4B	0.83	0.204
ACVR1B	IL20RB	0.825
ACVR1B	IFNGR1	0.824	0.174
PLEKHH3	LRP10	0.824	0.166
ACVR1B	PTPRS	0.82	0.074
PLEKHH3	RELT	0.816
LRP10	NDFIP1	0.809	0.202
PTPRS	PTPRF	0.808	0.184
TGFBR2	IFNGR1	0.807	0.198
LRP10	ACVR1B	0.803	0.116
TNFRSF10B	OSMR	0.803	0.178
NDFIP1	LAPTM4B	0.783	0.248
NDFIP1	PTPRF	0.782	0.052
ACVR1B	EPHA2	0.775	0.184
NDFIP1	JAK1	0.773	0.168
PTPRS	JAK1	0.773	0.104
RNF133	PTPRF	0.77
PLEKHH3	KCNE4	0.762
TGFBR2	EPHA2	0.759	0.256
PLEKHH3	EPHA2	0.746	0.296
EPHA2	UGCG	0.743	0.160941176471
ACVR2A	LAPTM4B	0.738
CSNK1G2	IFNGR1	0.731	0.098
CSNK1G1	PTPRF	0.723	0.046
OSMR	JAK1	0.718	0.174	structurally_consistent (dimer)
PTPRF	IFNGR1	0.716	0.086
BMPR1A	LAPTM4B	0.709	0.134
RELT	IFNGR1	0.704
RNF149	UGCG	0.702	0.19
PTPRF	EPHA2	0.699	0.302
TNFRSF10B	EPHA2	0.697	0.22
OSMR	NDFIP1	0.689	0.162
EPHA2	KCNE4	0.681
IL20RB	EPHA2	0.681
PTPRF	IL20RB	0.678
CSNK1G2	JAK1	0.674	0.24
JAK1	UGCG	0.67	0.18
ACVR2A	IFNGR1	0.656
TNFRSF10A	ACVR2A	0.649
OSMR	LAPTM4B	0.634	0.082
CSNK1G2	ACVR2A	0.63
RELT	PTPRS	0.627
ACVR1B	NDFIP1	0.627	0.08
PTPRD	JAK1	0.621	0.166
PLEKHH3	LAPTM4B	0.619	0.088
PLEKHH3	PTPRS	0.619	0.094
PTPRF	LAPTM4B	0.618	0.162
PLEKHH3	PTPRF	0.617	0.158
EPHA2	JAK1	0.617	0.222
PTPRD	RNF149	0.616	0.122
PLEKHH3	IFNGR1	0.616	0.114
CSNK1G1	EPHA2	0.613	0.116
CX3CL1	UGCG	0.609
OSMR	UGCG	0.597	0.138
PLEKHH3	ACVR1B	0.57	0.09
CSNK1G2	PTPRD	0.566	0.13
RNF133	EPHA2	0.559
NDFIP1	EPHA2	0.557	0.082
RNF149	LAPTM4B	0.554	0.154
PTPRS	TNFRSF10A	0.546	0.09
OSMR	EPHA2	0.54	0.114
PTPRS	LAPTM4B	0.539	0.066
PTPRD	LRP10	0.496	0.112
TNFRSF10A	LAPTM4B	0.449	0.1
PTPRD	ACVR2A	0.445
PTPRD	CX3CL1	0.441
PLEKHH3	OSMR	0.436	0.078
EPHA2	SYT11	0.421	0.152
OSMR	ACVR2A	0.418
PTPRD	ACVR1B	0.41	0.088
EPHA2	CX3CL1	0.407
OSMR	IFNGR1	0.404	0.17
PTPRD	NDFIP1	0.397	0.07
ACVR2B	NDFIP1	0.391
CSNK1G2	CX3CL1	0.377
CSNK1G2	BMPR1A	0.358	0.154
EPHA2	IFNGR1	0.328	0.144
PTPRD	PLEKHH3	0.32	0.066
PTPRD	EPHA2	0.316	0.21
CSNK1G1	PTPRS	0.314	0.056
CSNK1G1	NDFIP1	0.308	0.058
PTPRD	ACVR2B	0.307
EPHA2	LAPTM4B	0.307	0.14
PTPRD	IFNGR1	0.299	0.08
OSMR	PTPRF	0.298	0.06
CSNK1G1	UGCG	0.298	0.098
CSNK1G2	UGCG	0.279	0.098
ACVR2A	UGCG	0.278
CSNK1G2	OSMR	0.276	0.08
ACVR2B	RELT	0.275
CX3CL1	BMPR1A	0.274
OSMR	PTPRS	0.272	0.096
OSMR	TNFRSF10A	0.271	0.158
TNFRSF10A	EPHA2	0.262	0.298
PTPRD	RNF133	0.258
ACVR1B	OSMR	0.256	0.164
CSNK1G1	LAPTM4B	0.254	0.128
CSNK1G1	TNFRSF10A	0.249	0.146
PTPRD	BMPR1A	0.249	0.152
ACVR2B	IFNGR1	0.245
TNFRSF10B	PTPRD	0.24	0.16
RELT	UGCG	0.233
CX3CL1	RNF149	0.233
NDFIP1	CX3CL1	0.23
CSNK1G1	ACVR1B	0.209	0.132
ACVR2B	PTPRS	0.199
PLEKHH3	CX3CL1	0.193
RNF133	RNF149	0.187
CASP8	UGCG	0.176
PLEKHH3	UGCG	0.176	0.076
CSNK1G1	LRP10	0.171	0.116
PLEKHH3	TNFRSF10A	0.166	0.098
TNFRSF10B	CSNK1G1	0.164	0.094
JAK1	LAPTM4B	0.161	0.086
CX3CL1	JAK1	0.159
CASP8	LAPTM4B	0.155
FADD	UGCG	0.141	0.046
CSNK1G1	ACVR2A	0.137
PTPRD	OSMR	0.137	0.072
FADD	LAPTM4B	0.134	0.05
CSNK1G1	OSMR	0.133	0.12
FADD	BMPR1A	0.126	0.068
ACVR1B	LAPTM4B	0.126	0.106
FADD	LRP10	0.125	0.046
ACVR2B	CX3CL1	0.124
CSNK1G1	BMPR1A	0.121	0.13
LRP10	CASP8	0.115
CSNK1G1	JAK1	0.115	0.088
OSMR	RNF149	0.113	0.198
CSNK1G1	PLEKHH3	0.112	0.106
CSNK1G1	IFNGR1	0.111	0.134
TGFBR2	UGCG	0.102	0.132
RELT	CASP8	0.102
IL20RB	IFNGR1	0.101
FADD	ACVR1B	0.099	0.04
RELT	FADD	0.097
CSNK1G2	LAPTM4B	0.096	0.146
CASP8	BMPR1A	0.095
CSNK1G2	RELT	0.095
ACVR1B	CASP8	0.094
CASP8	RNF149	0.09
PTPRD	LAPTM4B	0.087	0.078
CSNK1G2	PLEKHH3	0.086	0.112
FADD	RNF149	0.086	0.088
NDFIP1	CASP8	0.084
RELT	LAPTM4B	0.079
CSNK1G1	RELT	0.075
PTPRF	CASP8	0.074
PTPRD	FADD	0.073	0.062
TNFRSF10B	PLEKHH3	0.072	0.124
PTPRD	UGCG	0.066	0.076
CSNK1G2	TGFBR2	0.061	0.14
PTPRD	CASP8	0.061
FADD	NDFIP1	0.053	0.05
PTPRD	PTPRS	0.05	0.088
ACVR1B	CX3CL1	0.049
FADD	PTPRF	0.047	0.012
ACVR2B	LAPTM4B	0.046
ACVR2B	TNFRSF10A	0.043
ACVR2B	OSMR	0.043
CASP8	IFNGR1	0.035
FADD	IFNGR1	0.034	0.102
PLEKHH3	TMEM204	0.033
RNF133	JAK1	0.032
PTPRF	CX3CL1	0.03
TMEM204	EPHA2	0.027
CSNK1G1	TGFBR2	0.027	0.11
CSNK1G1	ACVR2B	0.026
CASP8	EPHA2	0.022
ACVR2B	UGCG	0.022
FADD	EPHA2	0.021	0.0723763837638
FADD	ACVR2A	0.019
CASP8	ACVR2A	0.019
CASP8	JAK1	0.018
FADD	JAK1	0.013	0.072
FADD	PTPRS	0.01	0.068
PTPRS	CASP8	0.01

Related Complexes

Genename	Complexes
CX3CL1	huMAP3_04640.1 huMAP3_05650.1 huMAP3_11149.1 huMAP3_11997.1
LRP10	huMAP3_01934.1 huMAP3_07029.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1
LAPTM4B	huMAP3_07502.1 huMAP3_07536.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1
IFNGR1	huMAP3_06676.1 huMAP3_08953.1 huMAP3_11149.1 huMAP3_11605.1
RELT	huMAP3_01293.1 huMAP3_06149.1 huMAP3_07684.1 huMAP3_08598.1 huMAP3_08664.1 huMAP3_11149.1 huMAP3_11605.1
BMPR1A	huMAP3_06307.1 huMAP3_09249.1 huMAP3_11149.1 huMAP3_11605.1
JAK1	huMAP3_06384.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1
TMEM204	huMAP3_02078.1 huMAP3_03006.1 huMAP3_03859.1 huMAP3_04994.1 huMAP3_05434.1 huMAP3_05550.1 huMAP3_07383.1 huMAP3_08579.1 huMAP3_09144.1 huMAP3_09749.1 huMAP3_09880.1 huMAP3_10430.1 huMAP3_10877.1 huMAP3_11072.1 huMAP3_11149.1 huMAP3_13675.1
PTPRS	huMAP3_03666.1 huMAP3_06676.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1
CSNK1G1	huMAP3_00473.1 huMAP3_05335.1 huMAP3_07808.1 huMAP3_11149.1 huMAP3_11633.1 huMAP3_11729.1
NDFIP1	huMAP3_03585.1 huMAP3_05118.1 huMAP3_06676.1 huMAP3_09257.1 huMAP3_11149.1 huMAP3_11605.1
ACVR2B	huMAP3_00655.1 huMAP3_00866.1 huMAP3_04581.1 huMAP3_06211.1 huMAP3_08323.1 huMAP3_09249.1 huMAP3_10877.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_14203.1
ACVR2A	huMAP3_06384.1 huMAP3_09034.1 huMAP3_11149.1 huMAP3_11605.1
TNFRSF10B	huMAP3_00418.1 huMAP3_05118.1 huMAP3_06676.1 huMAP3_07502.1 huMAP3_08072.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_10476.1 huMAP3_11149.1 huMAP3_11605.1
RNF133	huMAP3_01244.1 huMAP3_09241.1 huMAP3_11149.1 huMAP3_11605.1
PTPRF	huMAP3_04362.1 huMAP3_07383.1 huMAP3_08579.1 huMAP3_09144.1 huMAP3_10877.1 huMAP3_11149.1 huMAP3_11605.1
UGCG	huMAP3_06676.1 huMAP3_07502.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_14909.1
CSNK1G2	huMAP3_00473.1 huMAP3_05335.1 huMAP3_07808.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_11870.1
SYT11	huMAP3_06676.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1
CASP8	huMAP3_04434.1 huMAP3_09961.1 huMAP3_10476.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_13943.1
EPHA2	huMAP3_04526.1 huMAP3_04581.1 huMAP3_06211.1 huMAP3_06834.1 huMAP3_11149.1 huMAP3_11605.1
CFLAR	huMAP3_04434.1 huMAP3_09961.1 huMAP3_10476.1 huMAP3_11149.1 huMAP3_13943.1
KCNE4	huMAP3_06676.1 huMAP3_07491.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_11149.1 huMAP3_11605.1
ACVR1B	huMAP3_02078.1 huMAP3_07383.1 huMAP3_08323.1 huMAP3_09144.1 huMAP3_10877.1 huMAP3_11149.1 huMAP3_11556.1 huMAP3_11605.1
OSMR	huMAP3_03006.1 huMAP3_08958.1 huMAP3_09749.1 huMAP3_11149.1 huMAP3_11605.1
IL20RB	huMAP3_04460.1 huMAP3_06092.1 huMAP3_06676.1 huMAP3_07845.1 huMAP3_08500.1 huMAP3_09642.1 huMAP3_09826.1 huMAP3_09977.1 huMAP3_11149.1 huMAP3_11605.1
TGFBR2	huMAP3_01062.1 huMAP3_05171.1 huMAP3_05659.1 huMAP3_06149.1 huMAP3_08664.1 huMAP3_09918.1 huMAP3_11149.1 huMAP3_11605.1
RNF149	huMAP3_06384.1 huMAP3_09034.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_11677.1
TNFRSF10A	huMAP3_03867.1 huMAP3_06676.1 huMAP3_07502.1 huMAP3_08072.1 huMAP3_08500.1 huMAP3_09826.1 huMAP3_10476.1 huMAP3_11149.1 huMAP3_11605.1
PLEKHH3	huMAP3_01062.1 huMAP3_04284.1 huMAP3_06307.1 huMAP3_09249.1 huMAP3_09796.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_14451.1
FADD	huMAP3_01926.1 huMAP3_03867.1 huMAP3_05118.1 huMAP3_06668.1 huMAP3_09961.1 huMAP3_11149.1 huMAP3_11605.1
PTPRD	huMAP3_00595.1 huMAP3_01062.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_14861.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11149.1

Complex Portal: CPX-13365