hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11158.1
Complex Portal: CPX-25517
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | 5 | UniProt NCBI |
| EMX2 | Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2) | 5 | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | 5 | UniProt NCBI |
| MSH3 | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) | 5 | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | 5 | UniProt NCBI |
| APTX | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | 5 | UniProt NCBI |
| TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03410 | 1.57296490579e-08 | 0.8 | POLB TDP1 PNKP APTX | Base excision repair |
| CORUM:362 | 4.09448956317e-05 | 0.4 | POLB PNKP | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| CORUM:5243 | 4.09448956317e-05 | 0.4 | TDP1 PNKP | XRCC1-LIG3-PNK-TDP1 complex |
| REAC:R-HSA-5649702 | 0.000319009353903 | 0.4 | POLB PNKP | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| HP:0003124 | 0.000447946694857 | 0.6 | APTX PNKP TDP1 | Hypercholesterolemia |
| HP:0012116 | 0.00192267581507 | 0.6 | APTX PNKP TDP1 | Abnormal circulating albumin concentration |
| HP:0003073 | 0.00192267581507 | 0.6 | APTX PNKP TDP1 | Hypoalbuminemia |
| HP:0002495 | 0.00237299419328 | 0.6 | APTX PNKP TDP1 | Impaired vibratory sensation |
| WP:WP4752 | 0.00254884296025 | 0.4 | POLB PNKP | Base excision repair |
| HP:0002936 | 0.00313025086245 | 0.6 | APTX PNKP TDP1 | Distal sensory impairment |
| HP:0010831 | 0.00393572415664 | 0.6 | APTX PNKP TDP1 | Impaired proprioception |
| HP:0003107 | 0.00433390348683 | 0.6 | APTX PNKP TDP1 | Abnormal circulating cholesterol concentration |
| REAC:R-HSA-73933 | 0.00900400267976 | 0.4 | POLB PNKP | Resolution of Abasic Sites (AP sites) |
| HP:0003693 | 0.0138556317341 | 0.6 | APTX PNKP TDP1 | Distal amyotrophy |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | POLB PNKP TDP1 | DNA Repair |
| WP:WP4016 | 0.017034501082 | 0.4 | POLB TDP1 | DNA IR damage and cellular response via ATR |
| HP:0001761 | 0.03503731332 | 0.6 | APTX PNKP TDP1 | Pes cavus |
| HP:0003119 | 0.0358640546012 | 0.6 | APTX PNKP TDP1 | Abnormal circulating lipid concentration |
| WP:WP4946 | 0.0366585107731 | 0.4 | POLB PNKP | DNA repair pathways full network |
| HP:0001284 | 0.0367035812988 | 0.6 | APTX PNKP TDP1 | Areflexia |
| REAC:R-HSA-73884 | 0.0428866281036 | 0.4 | POLB PNKP | Base Excision Repair |
| HP:0003380 | 0.0497672375822 | 0.4 | APTX TDP1 | Decreased number of peripheral myelinated nerve fibers |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| POLB | XRCC1 | 0.999 | 0.084 |
mutually_exclusive (P35244)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PNKP | POLB | 0.994 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | XRCC1 | 0.993 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| POLB | APTX | 0.99 | 0.134 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| POLB | TDP1 | 0.986 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | APTX | 0.958 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | APTX | 0.951 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| XRCC1 | TDP1 | 0.918 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| EMX2 | MSH3 | 0.895 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| EMX2 | PNKP | 0.891 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| EMX2 | POLB | 0.881 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PNKP | TDP1 | 0.862 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| TDP1 | APTX | 0.765 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | MSH3 | 0.396 | 0.196 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EMX2 | XRCC1 | 0.258 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| POLB | MSH3 | 0.224 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| TDP1 | MSH3 | 0.075 | 0.196 | bioplex_WMM youn_WMM WMM_only | |
| PNKP | MSH3 | 0.053 | 0.124 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes