hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11161.1

Complex Portal: CPX-11898

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
MAGEA1	Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)	5	UniProt NCBI
IRX4	Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4)	5	UniProt NCBI
PBX4	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	5	UniProt NCBI
MEIS3	Homeobox protein Meis3 (Meis1-related protein 2)	5	UniProt NCBI
MEIS1	Homeobox protein Meis1	5	UniProt NCBI
PBX3	Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)	5	UniProt NCBI
PBX1	Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)	5	UniProt NCBI
MEIS2	Homeobox protein Meis2 (Meis1-related protein 1)	5	UniProt NCBI
FAM222A	Protein FAM222A	2	UniProt NCBI
MAGEB6	Melanoma-associated antigen B6 (Cancer/testis antigen 3.4) (CT3.4) (MAGE-B6 antigen)	5	UniProt NCBI
SHOX	Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein)	5	UniProt NCBI
PKNOX2	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	5	UniProt NCBI
PBX2	Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)	5	UniProt NCBI
PKNOX1	Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)	5	UniProt NCBI
MAB21L1	Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0001654	1.8987111057e-08	0.571428571429	MEIS3 PBX2 MAB21L1 MEIS2 PBX3 PBX4 PBX1 MEIS1	eye development
GO:0150063	2.21881523328e-08	0.571428571429	MEIS3 PBX2 MAB21L1 MEIS2 PBX3 PBX4 PBX1 MEIS1	visual system development
GO:0048880	2.58506951688e-08	0.571428571429	MEIS3 PBX2 MAB21L1 MEIS2 PBX3 PBX4 PBX1 MEIS1	sensory system development
GO:0007423	2.21764210768e-07	0.571428571429	MEIS3 PBX2 MAB21L1 MEIS2 PBX3 PBX4 PBX1 MEIS1	sensory organ development
GO:0000978	5.95030142248e-06	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987	7.29905179002e-06	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	cis-regulatory region sequence-specific DNA binding
GO:0000981	2.23591670758e-05	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0006357	2.45383705396e-05	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	regulation of transcription by RNA polymerase II
GO:0000977	2.94923486591e-05	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003700	4.11267966154e-05	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	DNA-binding transcription factor activity
GO:0006366	4.59596967757e-05	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	transcription by RNA polymerase II
GO:0000976	6.80080977899e-05	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	transcription cis-regulatory region binding
GO:0001067	6.86910382528e-05	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	transcription regulatory region nucleic acid binding
GO:1990837	0.000107577105376	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	sequence-specific double-stranded DNA binding
GO:0043565	0.000216075020985	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	sequence-specific DNA binding
GO:0007420	0.000217262449942	0.5	MEIS3 PBX2 MEIS2 PBX3 PBX4 PBX1 MEIS1	brain development
GO:0003690	0.000221877055367	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	double-stranded DNA binding
GO:0060322	0.000291622089479	0.5	MEIS3 PBX2 MEIS2 PBX3 PBX4 PBX1 MEIS1	head development
GO:0006355	0.000788933082668	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	regulation of DNA-templated transcription
GO:2001141	0.000846654387404	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	regulation of RNA biosynthetic process
GO:0006351	0.00137134257161	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	DNA-templated transcription
GO:0140110	0.00146383566563	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	transcription regulator activity
GO:0032774	0.00155322980949	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	RNA biosynthetic process
GO:0009887	0.00164286404352	0.5	MEIS3 PBX2 MEIS2 PBX3 PBX4 PBX1 MEIS1	animal organ morphogenesis
GO:0009790	0.00178867416881	0.5	MEIS3 PBX2 MEIS2 PBX3 PBX4 PBX1 MEIS1	embryo development
GO:0000785	0.00181344690089	0.642857142857	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1	chromatin
GO:0051252	0.00290276006824	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	regulation of RNA metabolic process
GO:0032993	0.00302953776668	0.642857142857	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1	protein-DNA complex
GO:0007417	0.00426879408195	0.5	MEIS3 PBX2 MEIS2 PBX3 PBX4 PBX1 MEIS1	central nervous system development
GO:0003677	0.00431045510111	0.714285714286	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1 PKNOX2	DNA binding
HP:0011230	0.0054331440558	0.142857142857	MEIS2 MAB21L1	Laterally extended eyebrow
GO:0034654	0.00667701850949	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	nucleobase-containing compound biosynthetic process
GO:0018130	0.00824679764186	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	heterocycle biosynthetic process
GO:0019438	0.00834882837684	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	aromatic compound biosynthetic process
GO:0019219	0.0083830929296	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	regulation of nucleobase-containing compound metabolic process
GO:1901362	0.0116697820233	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	organic cyclic compound biosynthetic process
KEGG:05202	0.021738009856	0.214285714286	PBX1 MEIS1 PBX3	Transcriptional misregulation in cancer
WP:WP2857	0.0253481244899	0.214285714286	PBX1 MEIS1 PBX3	Mesodermal commitment pathway
GO:0048513	0.0268375706295	0.642857142857	IRX4 PBX2 PBX4 MAB21L1 MEIS2 PBX3 MEIS3 PBX1 MEIS1	animal organ development
REAC:R-HSA-5619507	0.0357756677588	0.214285714286	PBX1 MEIS1 PKNOX1	Activation of HOX genes during differentiation
REAC:R-HSA-5617472	0.0357756677588	0.214285714286	PBX1 MEIS1 PKNOX1	Activation of anterior HOX genes in hindbrain development during early embryogenesis
GO:0016070	0.0392907399865	0.857142857143	IRX4 PBX1 MAGEA1 PKNOX2 PKNOX1 MEIS2 PBX3 MEIS3 PBX4 MEIS1 PBX2 MAGEB6	RNA metabolic process
GO:0005694	0.0416953587303	0.642857142857	IRX4 PBX2 PBX4 PKNOX1 MEIS2 PBX3 MEIS3 PBX1 MEIS1	chromosome
GO:0009653	0.0465207288531	0.642857142857	MEIS3 PBX2 PKNOX1 MAB21L1 MEIS2 PBX3 PBX4 PBX1 MEIS1	anatomical structure morphogenesis

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PBX2	MEIS2	1.0	0.13	structurally_consistent (dimer)
MEIS2	MAB21L1	1.0	0.096
PBX2	MAB21L1	1.0	0.06
PBX3	MEIS2	1.0	0.206
PBX1	MEIS2	1.0	0.174	structurally_consistent (dimer)
MEIS1	MEIS2	0.999
MEIS2	PBX4	0.999		structurally_consistent (dimer)
PKNOX1	PBX4	0.999		structurally_consistent (dimer)
MEIS3	PBX4	0.999		structurally_consistent (dimer)
MEIS1	PBX4	0.997
MEIS1	MAB21L1	0.997
PKNOX1	PBX1	0.996	0.222	structurally_consistent (dimer)
MAGEA1	IRX4	0.996
PKNOX1	PBX2	0.995	0.242
PBX3	MAB21L1	0.995	0.084
PBX1	MAB21L1	0.994	0.098
PBX2	PKNOX2	0.992		mutually_exclusive (Q9BYU1)
MEIS2	MEIS3	0.99
MAGEA1	MAGEB6	0.99
PBX3	PKNOX2	0.988
MEIS2	FAM222A	0.983
PBX1	PBX2	0.982	0.246
PBX3	PBX2	0.977	0.182
PBX1	PBX3	0.976	0.142
FAM222A	MAB21L1	0.974
MEIS1	FAM222A	0.973
PBX1	PKNOX2	0.971
PBX2	PBX4	0.959		mutually_exclusive (O14770) structurally_consistent (dimer)
MEIS1	MEIS3	0.959
MAGEA1	PBX1	0.956
PBX2	MEIS1	0.953
PBX1	PBX4	0.952
PBX3	MEIS1	0.946
PBX1	MEIS1	0.946
PKNOX1	MEIS3	0.946		mutually_exclusive (Q9BYU1)
PKNOX2	PBX4	0.938		structurally_consistent (dimer)
PBX1	FAM222A	0.934
PKNOX1	SHOX	0.928
MAGEA1	PBX2	0.917
PBX3	FAM222A	0.912
PBX1	SHOX	0.91
PBX2	FAM222A	0.896
IRX4	PBX2	0.892
IRX4	PBX1	0.885
PBX3	PBX4	0.862
MEIS1	PKNOX2	0.801
PKNOX1	MEIS1	0.77
PKNOX1	MEIS2	0.726	0.164	mutually_exclusive (P40424)
MAGEA1	PBX3	0.719
PKNOX1	PKNOX2	0.558
MEIS2	PKNOX2	0.552
MEIS3	PKNOX2	0.415		mutually_exclusive (Q9BYU1)
MAGEB6	PBX3	0.378
PBX2	MEIS3	0.35		mutually_exclusive (Q9BYU1)
MAGEB6	PBX1	0.336
PBX2	SHOX	0.232
PKNOX1	PBX3	0.226	0.14
MAB21L1	PBX4	0.224
IRX4	MAGEB6	0.214
MAGEB6	PBX2	0.2
PBX3	SHOX	0.194
MAB21L1	PKNOX2	0.188
IRX4	PBX3	0.131
PBX3	MEIS3	0.058
MAB21L1	MEIS3	0.058
PBX1	MEIS3	0.042

Related Complexes

Genename	Complexes
MAGEA1	huMAP3_00127.1 huMAP3_05978.1 huMAP3_09506.1 huMAP3_10728.1 huMAP3_11161.1
IRX4	huMAP3_00127.1 huMAP3_05978.1 huMAP3_09506.1 huMAP3_10728.1 huMAP3_11161.1
PBX4	huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
MEIS3	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
MEIS1	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
PBX3	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
PBX1	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
MEIS2	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1
FAM222A	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1 huMAP3_14247.1
MAGEB6	huMAP3_00127.1 huMAP3_05978.1 huMAP3_09506.1 huMAP3_10728.1 huMAP3_11161.1
SHOX	huMAP3_00942.1 huMAP3_11161.1
PKNOX2	huMAP3_06535.1 huMAP3_07040.1 huMAP3_10521.1 huMAP3_10672.1 huMAP3_11161.1
PBX2	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
PKNOX1	huMAP3_00470.1 huMAP3_06535.1 huMAP3_10672.1 huMAP3_11161.1
MAB21L1	huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11161.1

Complex Portal: CPX-11898