hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11168.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
E2F5	Transcription factor E2F5 (E2F-5)	5	UniProt NCBI
RBL2	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	5	UniProt NCBI
LIN52	Protein lin-52 homolog	3	UniProt NCBI
RBL1	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)	5	UniProt NCBI
TFDP2	Transcription factor Dp-2 (E2F dimerization partner 2)	5	UniProt NCBI
E2F1	Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)	5	UniProt NCBI
E2F4	Transcription factor E2F4 (E2F-4)	5	UniProt NCBI
LIN37	Protein lin-37 homolog (Antolefinin)	5	UniProt NCBI
LIN54	Protein lin-54 homolog (CXC domain-containing protein 1)	5	UniProt NCBI
E2F2	Transcription factor E2F2 (E2F-2)	5	UniProt NCBI
MYBL2	Myb-related protein B (B-Myb) (Myb-like protein 2)	5	UniProt NCBI
MYBL1	Myb-related protein A (A-Myb) (Myb-like protein 1)	5	UniProt NCBI
MCIDAS	Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas)	5	UniProt NCBI
LIN9	Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein)	5	UniProt NCBI
RB1	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	5	UniProt NCBI
E2F3	Transcription factor E2F3 (E2F-3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1362300	1.16742835189e-23	0.692307692308	E2F1 LIN54 E2F4 RBL2 LIN37 RBL1 TFDP2 E2F5 LIN9	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
REAC:R-HSA-1362277	1.1332345532e-22	0.692307692308	E2F1 LIN54 E2F4 RBL2 LIN37 RBL1 TFDP2 E2F5 LIN9	Transcription of E2F targets under negative control by DREAM complex
REAC:R-HSA-453279	2.39134249052e-21	0.923076923077	E2F1 LIN54 E2F4 RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	Mitotic G1 phase and G1/S transition
REAC:R-HSA-1538133	7.26834022312e-21	0.692307692308	E2F1 LIN54 E2F4 RBL2 LIN37 RBL1 TFDP2 E2F5 LIN9	G0 and Early G1
REAC:R-HSA-69205	1.08998204166e-20	0.692307692308	E2F1 LIN54 E2F4 RBL2 LIN37 RBL1 TFDP2 E2F5 LIN9	G1/S-Specific Transcription
KEGG:04218	1.83526759842e-19	0.846153846154	E2F1 E2F4 RBL2 E2F3 E2F5 RBL1 RB1 E2F2 LIN54 LIN37 LIN9	Cellular senescence
REAC:R-HSA-69231	2.55019300185e-18	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	Cyclin D associated events in G1
REAC:R-HSA-69236	2.55019300185e-18	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	G1 Phase
REAC:R-HSA-69206	1.66634622143e-16	0.769230769231	E2F1 LIN54 E2F4 RBL2 LIN37 RBL1 RB1 TFDP2 E2F5 LIN9	G1/S Transition
REAC:R-HSA-69202	6.72328454306e-16	0.692307692308	E2F1 LIN54 E2F4 RBL2 E2F5 RB1 TFDP2 LIN37 LIN9	Cyclin E associated events during G1/S transition
REAC:R-HSA-69656	8.44171783538e-16	0.692307692308	E2F1 LIN54 E2F4 RBL2 E2F5 RB1 TFDP2 LIN37 LIN9	Cyclin A:Cdk2-associated events at S phase entry
WP:WP5180	2.99369365988e-15	0.615384615385	LIN54 E2F4 RBL2 LIN37 RBL1 TFDP2 E2F5 LIN9	DYRK1A involvement regarding cell proliferation in brain development
WP:WP179	7.41557049434e-15	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	Cell cycle
REAC:R-HSA-69278	1.43690321658e-14	0.923076923077	E2F1 LIN54 E2F4 RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	Cell Cycle, Mitotic
KEGG:04110	4.16516148809e-14	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	Cell cycle
CORUM:5596	7.80900880046e-14	0.384615384615	LIN9 RBL2 LIN54 E2F4 LIN37	LINC complex, quiescent cells
REAC:R-HSA-1640170	1.7511803312e-13	0.923076923077	E2F1 LIN54 E2F4 RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	Cell Cycle
REAC:R-HSA-69242	3.19902893508e-13	0.692307692308	E2F1 LIN54 E2F4 RBL2 E2F5 RB1 TFDP2 LIN37 LIN9	S Phase
CORUM:5589	1.05641911521e-10	0.307692307692	LIN9 RBL1 LIN37 LIN54	LINC complex, S-phase
REAC:R-HSA-9659787	3.89720180039e-10	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
REAC:R-HSA-9661069	3.89720180039e-10	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
GO:0005667	9.46440875379e-10	0.769230769231	E2F1 E2F4 RBL2 E2F3 LIN54 RBL1 RB1 E2F2 TFDP2 E2F5	transcription regulator complex
REAC:R-HSA-2559585	1.48385650593e-08	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Oncogene Induced Senescence
REAC:R-HSA-9687139	2.0277885345e-08	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Aberrant regulation of mitotic cell cycle due to RB1 defects
REAC:R-HSA-9675126	2.72030893995e-08	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Diseases of mitotic cell cycle
REAC:R-HSA-6791312	7.59681560682e-08	0.384615384615	RBL2 TFDP2 E2F4 E2F1 RBL1	TP53 Regulates Transcription of Cell Cycle Genes
CORUM:5593	1.23488636402e-07	0.230769230769	LIN9 LIN37 LIN54	LINC core complex
WP:WP45	2.00951313738e-07	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	G1 to S cell cycle control
REAC:R-HSA-6804114	2.43115552171e-07	0.307692307692	RBL2 TFDP2 E2F4 RBL1	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
CORUM:5117	3.08563128138e-07	0.230769230769	RBL2 E2F5 E2F4	RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2)
CORUM:2975	3.08563128138e-07	0.230769230769	RBL1 E2F5 E2F4	SMAD3-E2F4/5-p107-DP1 complex
CORUM:1474	6.16809486722e-07	0.230769230769	RBL1 E2F5 E2F4	SMAD3/4-E2F4/5-p107-DP1 complex
CORUM:5118	6.16809486722e-07	0.230769230769	RBL2 E2F5 E2F4	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)
WP:WP2446	9.08681163422e-07	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Retinoblastoma gene in cancer
KEGG:05219	1.24812223281e-06	0.307692307692	E2F1 E2F3 RB1 E2F2	Bladder cancer
WP:WP236	2.74721431007e-06	0.384615384615	RBL2 E2F4 E2F1 RB1 RBL1	Adipogenesis
REAC:R-HSA-2173796	5.9609772212e-06	0.307692307692	RBL1 E2F4 E2F5 TFDP2	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
GO:0090575	7.70462433135e-06	0.538461538462	E2F1 E2F4 E2F3 RB1 E2F2 TFDP2 E2F5	RNA polymerase II transcription regulator complex
KEGG:05218	1.16692731435e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Melanoma
WP:WP53	1.40653969659e-05	0.230769230769	RBL2 RB1 RBL1	ID signaling pathway
KEGG:05223	1.69852838622e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Non-small cell lung cancer
KEGG:05214	1.69852838622e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Glioma
WP:WP4685	2.08507558964e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Melanoma
GO:0001067	2.08852058507e-05	0.769230769231	E2F1 E2F4 RBL2 E2F3 LIN54 RBL1 RB1 E2F2 TFDP2 E2F5	transcription regulatory region nucleic acid binding
KEGG:05212	2.14146744681e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Pancreatic cancer
REAC:R-HSA-2173793	2.31450505854e-05	0.307692307692	RBL1 E2F4 E2F5 TFDP2	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
KEGG:05220	2.39270815029e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Chronic myeloid leukemia
WP:WP4255	3.26607452266e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Non small cell lung cancer
KEGG:01522	3.62278994384e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Endocrine resistance
CORUM:1250	4.10333215354e-05	0.153846153846	E2F1 RB1	RB-E2F1 complex
CORUM:5099	4.10333215354e-05	0.153846153846	RB1 E2F4	RB1(hypophosphorylated)-E2F4 complex
CORUM:5143	4.10333215354e-05	0.153846153846	E2F1 RB1	RB-E2F1 complex
CORUM:5159	4.10333215354e-05	0.153846153846	RBL1 E2F4	E2F4-p107-cyclinE complex
CORUM:5160	4.10333215354e-05	0.153846153846	RBL2 E2F4	E2F4-p130 complex
CORUM:5656	4.10333215354e-05	0.153846153846	E2F1 RB1	CEBPE-E2F1-RB1 complex
GO:0003677	4.15806009546e-05	0.846153846154	E2F1 E2F4 RBL2 E2F3 LIN54 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	DNA binding
REAC:R-HSA-113501	4.27430012802e-05	0.230769230769	TFDP2 RB1 E2F1	Inhibition of replication initiation of damaged DNA by RB1/E2F1
KEGG:05222	4.38978472079e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Small cell lung cancer
KEGG:05215	5.2716193882e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Prostate cancer
REAC:R-HSA-156711	6.79304263505e-05	0.230769230769	LIN9 LIN37 LIN54	Polo-like kinase mediated events
WP:WP4263	7.0405442475e-05	0.307692307692	E2F1 E2F3 RB1 E2F2	Pancreatic adenocarcinoma pathway
REAC:R-HSA-2559583	7.56364807749e-05	0.384615384615	TFDP2 E2F3 E2F2 RB1 E2F1	Cellular Senescence
WP:WP4658	0.000102915876951	0.307692307692	E2F1 E2F3 RB1 E2F2	Small cell lung cancer
GO:0035189	0.000109904886398	0.230769230769	E2F1 RB1 E2F2	Rb-E2F complex
REAC:R-HSA-453274	0.000116848819066	0.384615384615	LIN9 E2F1 E2F3 LIN37 LIN54	Mitotic G2-G2/M phases
CORUM:5144	0.00012303818858	0.153846153846	RBL1 E2F1	E2F1-p107-cyclinA complex
CORUM:1661	0.00012303818858	0.153846153846	RBL1 E2F4	E2F4-p107-cyclinA complex
CORUM:1488	0.00012303818858	0.153846153846	E2F1 RB1	DNMT1-RB1-HDAC1-E2F1 complex
CORUM:1473	0.00012303818858	0.153846153846	RBL2 E2F5	E2F5-RB2-DP1 complex
KEGG:04934	0.000196510562353	0.307692307692	E2F1 E2F3 RB1 E2F2	Cushing syndrome
KEGG:05224	0.000209346257122	0.307692307692	E2F1 E2F3 RB1 E2F2	Breast cancer
REAC:R-HSA-170834	0.000219649400377	0.307692307692	RBL1 E2F4 E2F5 TFDP2	Signaling by TGF-beta Receptor Complex
REAC:R-HSA-113510	0.000229093302057	0.230769230769	TFDP2 RB1 E2F1	E2F mediated regulation of DNA replication
KEGG:05226	0.000236871836576	0.307692307692	E2F1 E2F3 RB1 E2F2	Gastric cancer
KEGG:05160	0.000236871836576	0.307692307692	E2F1 E2F3 RB1 E2F2	Hepatitis C
GO:0010468	0.000247117293589	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of gene expression
WP:WP366	0.000329776436244	0.307692307692	RBL2 E2F4 E2F5 RBL1	TGF beta signaling pathway
GO:0000977	0.000346455879291	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0010556	0.000370272384588	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of macromolecule biosynthetic process
KEGG:05161	0.000384717586203	0.307692307692	E2F1 E2F3 RB1 E2F2	Hepatitis B
CORUM:1471	0.00040971577212	0.153846153846	RBL2 E2F5	pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
GO:0031326	0.000492892767642	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of cellular biosynthetic process
REAC:R-HSA-2559580	0.000504232320379	0.307692307692	TFDP2 E2F2 E2F3 E2F1	Oxidative Stress Induced Senescence
KEGG:05225	0.000511155600905	0.307692307692	E2F1 E2F3 RB1 E2F2	Hepatocellular carcinoma
WP:WP4262	0.000513779613998	0.307692307692	E2F1 E2F3 RB1 E2F2	Breast cancer pathway
REAC:R-HSA-9006936	0.000523366871463	0.307692307692	RBL1 E2F4 E2F5 TFDP2	Signaling by TGFB family members
GO:0009889	0.000532309914801	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of biosynthetic process
CORUM:6444	0.000614265253436	0.153846153846	RBL2 RBL1	SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex
KEGG:05167	0.000635557324889	0.307692307692	E2F1 E2F3 RB1 E2F2	Kaposi sarcoma-associated herpesvirus infection
GO:0005654	0.000642773776147	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	nucleoplasm
GO:0000785	0.000688413598146	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	chromatin
GO:0000976	0.000733192108642	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	transcription cis-regulatory region binding
KEGG:05169	0.000834586097891	0.307692307692	E2F1 E2F3 RB1 E2F2	Epstein-Barr virus infection
KEGG:05163	0.00107625857485	0.307692307692	E2F1 E2F3 RB1 E2F2	Human cytomegalovirus infection
GO:1990837	0.00110633674183	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	sequence-specific double-stranded DNA binding
GO:0032993	0.00115449882113	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	protein-DNA complex
KEGG:05166	0.00121477388075	0.307692307692	E2F1 E2F3 RB1 E2F2	Human T-cell leukemia virus 1 infection
GO:0031981	0.00148875347378	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	nuclear lumen
GO:0043550	0.00153551162834	0.230769230769	RBL2 RB1 RBL1	regulation of lipid kinase activity
GO:0001216	0.00174559545982	0.461538461538	E2F1 E2F4 E2F5 E2F2 TFDP2 E2F3	DNA-binding transcription activator activity
REAC:R-HSA-3700989	0.00193896131662	0.384615384615	RBL2 TFDP2 E2F4 E2F1 RBL1	Transcriptional Regulation by TP53
REAC:R-HSA-68911	0.00199260676058	0.153846153846	E2F1 E2F3	G2 Phase
REAC:R-HSA-111448	0.00199260676058	0.153846153846	TFDP2 E2F1	Activation of NOXA and translocation to mitochondria
GO:0043565	0.00206809318276	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	sequence-specific DNA binding
GO:0003690	0.00211783150724	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	double-stranded DNA binding
GO:0140513	0.00213464356125	0.692307692308	E2F1 E2F4 LIN37 E2F3 E2F5 RB1 E2F2 TFDP2 LIN54	nuclear protein-containing complex
CORUM:5611	0.00224666054346	0.153846153846	RBL2 RB1	Emerin complex 24
REAC:R-HSA-212436	0.00263447397095	0.538461538462	E2F1 E2F4 RBL2 RBL1 RB1 TFDP2 E2F5	Generic Transcription Pathway
WP:000000	0.00311598470754	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	WIKIPATHWAYS
KEGG:04350	0.00319307127413	0.230769230769	RBL1 E2F5 E2F4	TGF-beta signaling pathway
GO:0006355	0.00430535344115	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	regulation of DNA-templated transcription
GO:2001141	0.00459246252839	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	regulation of RNA biosynthetic process
GO:0060255	0.00504267470121	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of macromolecule metabolic process
GO:0006357	0.00505431373159	0.769230769231	E2F1 E2F4 MCIDAS E2F3 LIN37 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of transcription by RNA polymerase II
GO:0031323	0.00519983036922	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of cellular metabolic process
REAC:R-HSA-73857	0.00544250481316	0.538461538462	E2F1 E2F4 RBL2 RBL1 RB1 TFDP2 E2F5	RNA Polymerase II Transcription
KEGG:05165	0.00568635345795	0.307692307692	RBL2 E2F1 RB1 RBL1	Human papillomavirus infection
CORUM:5614	0.00695708221026	0.153846153846	RBL2 RBL1	Emerin complex 32
GO:0006351	0.00713701566553	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	DNA-templated transcription
REAC:R-HSA-139915	0.00715899645867	0.153846153846	TFDP2 E2F1	Activation of PUMA and translocation to mitochondria
WP:WP2431	0.00721580476655	0.230769230769	E2F1 E2F5 RB1	Spinal cord injury
GO:0010467	0.0074734456447	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	gene expression
WP:WP3969	0.0077180657803	0.153846153846	E2F1 RB1	H19 action Rb E2F1 signaling and CDK Beta catenin activity
GO:0032774	0.00799764715634	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	RNA biosynthetic process
GO:0006366	0.00845149473208	0.769230769231	E2F1 E2F4 MCIDAS E2F3 LIN37 RB1 E2F2 TFDP2 E2F5 LIN9	transcription by RNA polymerase II
REAC:R-HSA-1912408	0.0101717446382	0.230769230769	TFDP2 E2F3 E2F1	Pre-NOTCH Transcription and Translation
GO:0000082	0.01096382655	0.384615384615	RBL2 E2F3 E2F1 RB1 RBL1	G1/S transition of mitotic cell cycle
REAC:R-HSA-74160	0.0123811504483	0.538461538462	E2F1 E2F4 RBL2 RBL1 RB1 TFDP2 E2F5	Gene expression (Transcription)
GO:0051252	0.0141643501886	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	regulation of RNA metabolic process
GO:0019222	0.0152524190501	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	regulation of metabolic process
KEGG:05206	0.0154550895581	0.230769230769	E2F1 E2F3 E2F2	MicroRNAs in cancer
GO:0005694	0.016278404599	0.692307692308	E2F1 E2F4 RBL2 E2F3 RBL1 RB1 E2F2 TFDP2 E2F5	chromosome
REAC:R-HSA-1912422	0.0180213476636	0.230769230769	TFDP2 E2F3 E2F1	Pre-NOTCH Expression and Processing
GO:0044843	0.0202942453403	0.384615384615	RBL2 E2F3 E2F1 RB1 RBL1	cell cycle G1/S phase transition
GO:0009059	0.0217204773108	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	macromolecule biosynthetic process
GO:0070013	0.0244298182677	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	intracellular organelle lumen
GO:0031974	0.0244298182677	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	membrane-enclosed lumen
GO:0043233	0.0244298182677	1.0	E2F1 LIN54 E2F4 MCIDAS RBL2 E2F3 LIN37 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	organelle lumen
KEGG:05200	0.028109729248	0.307692307692	E2F1 E2F3 RB1 E2F2	Pathways in cancer
GO:0003676	0.0286323529083	0.846153846154	E2F1 E2F4 RBL2 E2F3 LIN54 RBL1 RB1 E2F2 TFDP2 E2F5 LIN9	nucleic acid binding
KEGG:05203	0.0302093677775	0.230769230769	RBL2 RB1 RBL1	Viral carcinogenesis
GO:0034654	0.0303256217626	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	nucleobase-containing compound biosynthetic process
WP:WP5121	0.031835197324	0.153846153846	E2F1 RB1	Sphingolipid metabolism in senescence
GO:0018130	0.0367791392248	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	heterocycle biosynthetic process
GO:0019438	0.0371946868599	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	aromatic compound biosynthetic process
GO:0019219	0.0373341395785	0.846153846154	E2F1 E2F4 LIN37 MCIDAS E2F3 E2F5 RB1 E2F2 TFDP2 LIN54 LIN9	regulation of nucleobase-containing compound metabolic process
WP:WP5202	0.0416894057602	0.153846153846	TFDP2 E2F4	Alstrom syndrome
WP:WP2828	0.0499352504887	0.153846153846	E2F1 RB1	Bladder cancer
CORUM:5663	0.0499717467432	0.0769230769231	RB1	TRIM27-RB1 complex
CORUM:839	0.0499717467432	0.0769230769231	LIN9	LIN9-BMYB complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
LIN37	LIN54	1.0	0.148
LIN37	LIN9	1.0	0.174
LIN52	LIN9	1.0	0.198
LIN37	MYBL2	1.0	0.164
LIN54	LIN9	1.0	0.324
LIN52	LIN37	1.0	0.18
MYBL2	LIN9	1.0	0.248
MYBL1	LIN9	0.999
LIN37	MYBL1	0.999
LIN52	MYBL1	0.999
E2F4	TFDP2	0.998	0.16
LIN52	LIN54	0.998	0.21
E2F5	TFDP2	0.998
TFDP2	E2F2	0.997
LIN54	MYBL1	0.997
RBL2	RBL1	0.996	0.118
TFDP2	E2F3	0.996	0.152
TFDP2	E2F1	0.991
LIN52	MYBL2	0.99	0.184
MCIDAS	TFDP2	0.985
LIN37	E2F5	0.983
E2F4	E2F5	0.974
LIN9	TFDP2	0.972	0.226
E2F4	LIN37	0.969	0.146
LIN37	TFDP2	0.967	0.164
LIN37	RBL1	0.967	0.16
RBL2	TFDP2	0.967	0.122
MYBL2	MYBL1	0.967
LIN54	TFDP2	0.966	0.182
RBL1	TFDP2	0.966	0.158
RBL2	LIN37	0.965	0.08
LIN54	MYBL2	0.965	0.206
RB1	TFDP2	0.963	0.206
LIN52	TFDP2	0.962	0.2
RBL1	LIN9	0.962	0.184
E2F2	E2F3	0.961
RBL2	LIN9	0.96	0.122
E2F5	E2F2	0.959
E2F4	LIN9	0.941	0.108
E2F4	E2F3	0.936	0.174
RB1	E2F2	0.926
E2F5	E2F3	0.924
E2F4	E2F2	0.917
MCIDAS	E2F2	0.902
MCIDAS	E2F3	0.902
LIN52	E2F2	0.902
E2F4	RB1	0.9	0.162
LIN9	E2F2	0.892
LIN52	MCIDAS	0.892
MCIDAS	E2F5	0.892
RB1	E2F3	0.888	0.136
RBL1	RB1	0.877	0.216
LIN54	E2F2	0.869
E2F4	MCIDAS	0.76
LIN9	MCIDAS	0.754
RB1	E2F5	0.751
LIN54	MCIDAS	0.715
RBL1	E2F2	0.703
LIN52	E2F3	0.688	0.138
RBL2	E2F2	0.676
MCIDAS	RB1	0.634
LIN54	E2F5	0.633
LIN52	E2F5	0.633
E2F4	MYBL1	0.616
MYBL1	TFDP2	0.616
RBL2	MYBL1	0.616
E2F4	MYBL2	0.616	0.214
MYBL2	RBL1	0.616	0.238
RBL1	MYBL1	0.616
MYBL2	TFDP2	0.616	0.218
RBL2	MYBL2	0.616	0.12
E2F1	E2F3	0.582
E2F1	E2F2	0.568
E2F5	E2F1	0.541
E2F4	RBL1	0.526	0.154
E2F4	RBL2	0.524	0.09
RBL1	E2F3	0.468	0.138
RBL1	MCIDAS	0.455
LIN9	E2F5	0.428
RBL2	E2F3	0.418	0.12
RBL2	MCIDAS	0.405
LIN52	RBL2	0.404	0.066
E2F4	LIN52	0.404	0.128
RBL2	E2F5	0.404
LIN52	RBL1	0.404	0.108
MYBL2	E2F5	0.388
MYBL1	E2F5	0.388
RBL1	E2F5	0.384
E2F4	E2F1	0.378
LIN54	RBL1	0.372	0.206
RBL2	LIN54	0.36	0.128
LIN9	E2F3	0.357	0.162
E2F4	LIN54	0.352	0.11
LIN54	E2F3	0.341	0.17
RBL2	RB1	0.282	0.158
LIN52	RB1	0.261	0.15
LIN9	RB1	0.258	0.132
LIN52	E2F1	0.214
MCIDAS	E2F1	0.214
LIN54	RB1	0.196	0.156
RB1	E2F1	0.149
RBL1	E2F1	0.146
LIN9	E2F1	0.131
RBL2	E2F1	0.131
LIN54	E2F1	0.108
MYBL2	E2F3	0.022	0.138
LIN37	RB1	0.016	0.182
MYBL2	RB1	0.013	0.078

Related Complexes

Genename	Complexes
E2F5	huMAP3_03477.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_13863.1 huMAP3_14722.1
RBL2	huMAP3_00487.1 huMAP3_03477.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12923.1 huMAP3_14722.1
LIN52	huMAP3_00487.1 huMAP3_03164.1 huMAP3_07470.1 huMAP3_08170.1 huMAP3_10910.1 huMAP3_11168.1
RBL1	huMAP3_00487.1 huMAP3_03164.1 huMAP3_03477.1 huMAP3_05269.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
TFDP2	huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_14051.1
E2F1	huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_14051.1
E2F4	huMAP3_00125.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1
LIN37	huMAP3_00487.1 huMAP3_03164.1 huMAP3_06412.1 huMAP3_07470.1 huMAP3_08170.1 huMAP3_10910.1 huMAP3_11168.1
LIN54	huMAP3_00487.1 huMAP3_03164.1 huMAP3_07470.1 huMAP3_08170.1 huMAP3_10910.1 huMAP3_11168.1
E2F2	huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1
MYBL2	huMAP3_00487.1 huMAP3_03164.1 huMAP3_07470.1 huMAP3_08170.1 huMAP3_10910.1 huMAP3_11168.1
MYBL1	huMAP3_00487.1 huMAP3_03164.1 huMAP3_07470.1 huMAP3_08170.1 huMAP3_10910.1 huMAP3_11168.1
MCIDAS	huMAP3_02716.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1
LIN9	huMAP3_00487.1 huMAP3_03164.1 huMAP3_07470.1 huMAP3_08170.1 huMAP3_10910.1 huMAP3_11168.1
RB1	huMAP3_02854.1 huMAP3_03241.1 huMAP3_06586.1 huMAP3_08879.1 huMAP3_11168.1
E2F3	huMAP3_04355.1 huMAP3_05947.1 huMAP3_10910.1 huMAP3_11168.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11168.1