hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11188.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IGFBP4 | Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4) | 5 | UniProt NCBI |
| MAML1 | Mastermind-like protein 1 (Mam-1) | 5 | UniProt NCBI |
| ZNF783 | Zinc finger protein 783 | 5 | UniProt NCBI |
| CCN6 | Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3) | 5 | UniProt NCBI |
| CRISPLD1 | Cysteine-rich secretory protein LCCL domain-containing 1 (CocoaCrisp) (Cysteine-rich secretory protein 10) (CRISP-10) (LCCL domain-containing cysteine-rich secretory protein 1) (Trypsin inhibitor Hl) | 4 | UniProt NCBI |
| NOTCH1 | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | 5 | UniProt NCBI |
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | 5 | UniProt NCBI |
| NOTCH2 | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | 5 | UniProt NCBI |
| WNT2 | Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3113 | 9.82248594942e-09 | 0.375 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 9.82248594942e-09 | 0.375 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 9.82248594942e-09 | 0.375 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| REAC:R-HSA-9013695 | 1.0672851369e-08 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | NOTCH4 Intracellular Domain Regulates Transcription |
| WP:WP3845 | 1.29848862028e-08 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Canonical and non canonical Notch signaling |
| REAC:R-HSA-350054 | 5.71078496603e-08 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Notch-HLH transcription pathway |
| KEGG:04330 | 3.51438433791e-07 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| WP:WP61 | 4.52289153183e-07 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| REAC:R-HSA-2197563 | 8.0085934553e-07 | 0.375 | MAML1 NOTCH2 RBPJ | NOTCH2 intracellular domain regulates transcription |
| KEGG:04658 | 2.06635644055e-06 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Th1 and Th2 cell differentiation |
| CORUM:2639 | 2.1559600425e-06 | 0.375 | MAML1 RBPJ NOTCH1 | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-210744 | 3.77160472982e-06 | 0.375 | MAML1 RBPJ NOTCH1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-8941856 | 3.77160472982e-06 | 0.375 | MAML1 RBPJ NOTCH1 | RUNX3 regulates NOTCH signaling |
| GO:0002193 | 5.38272230028e-06 | 0.375 | MAML1 RBPJ NOTCH1 | MAML1-RBP-Jkappa- ICN1 complex |
| GO:0007221 | 5.38272230028e-06 | 0.375 | MAML1 RBPJ NOTCH1 | positive regulation of transcription of Notch receptor target |
| KEGG:05165 | 8.40198354629e-06 | 0.625 | WNT2 NOTCH2 MAML1 RBPJ NOTCH1 | Human papillomavirus infection |
| REAC:R-HSA-9013694 | 8.4027319934e-06 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Signaling by NOTCH4 |
| REAC:R-HSA-1912408 | 9.89810058296e-06 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Pre-NOTCH Transcription and Translation |
| WP:WP4787 | 1.39792262794e-05 | 0.5 | WNT2 NOTCH1 NOTCH2 RBPJ | Osteoblast differentiation and related diseases |
| REAC:R-HSA-9793380 | 1.86188034187e-05 | 0.375 | MAML1 RBPJ NOTCH1 | Formation of paraxial mesoderm |
| REAC:R-HSA-1912422 | 2.14810904075e-05 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Pre-NOTCH Expression and Processing |
| CORUM:2946 | 2.39226645298e-05 | 0.25 | NOTCH1 RBPJ | YY1-Notch1-RBP-Jkappa complex |
| CORUM:2907 | 2.39226645298e-05 | 0.25 | NOTCH1 RBPJ | RBP-Jkappa-Notch1 complex |
| REAC:R-HSA-9013508 | 2.59982063947e-05 | 0.375 | MAML1 RBPJ NOTCH1 | NOTCH3 Intracellular Domain Regulates Transcription |
| WP:WP4239 | 3.94852997453e-05 | 0.5 | WNT2 NOTCH1 NOTCH2 RBPJ | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-1980145 | 4.61108204583e-05 | 0.375 | MAML1 NOTCH2 RBPJ | Signaling by NOTCH2 |
| REAC:R-HSA-186712 | 5.23852014749e-05 | 0.375 | MAML1 RBPJ NOTCH1 | Regulation of beta-cell development |
| WP:WP268 | 6.95406701237e-05 | 0.375 | MAML1 NOTCH2 NOTCH1 | Notch signaling |
| REAC:R-HSA-9758941 | 0.000176426072101 | 0.375 | MAML1 RBPJ NOTCH1 | Gastrulation |
| REAC:R-HSA-9012852 | 0.000207404030729 | 0.375 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH3 |
| REAC:R-HSA-2122947 | 0.000224162952172 | 0.375 | MAML1 RBPJ NOTCH1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-5083630 | 0.000334530488176 | 0.25 | NOTCH1 NOTCH2 | Defective LFNG causes SCDO3 |
| REAC:R-HSA-2644603 | 0.000367233569698 | 0.375 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2894858 | 0.000367233569698 | 0.375 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894862 | 0.000367233569698 | 0.375 | MAML1 RBPJ NOTCH1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644602 | 0.000367233569698 | 0.375 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644606 | 0.000367233569698 | 0.375 | MAML1 RBPJ NOTCH1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| WP:WP2840 | 0.000422264830312 | 0.375 | NOTCH1 NOTCH2 RBPJ | Hair follicle development cytodifferentiation part 3 of 3 |
| REAC:R-HSA-157118 | 0.000525460865622 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Signaling by NOTCH |
| WP:WP4674 | 0.000528504119386 | 0.375 | MAML1 NOTCH2 NOTCH1 | Head and neck squamous cell carcinoma |
| REAC:R-HSA-1912399 | 0.000557398190654 | 0.25 | NOTCH1 NOTCH2 | Pre-NOTCH Processing in the Endoplasmic Reticulum |
| WP:WP2064 | 0.000625219299609 | 0.375 | NOTCH1 NOTCH2 RBPJ | Neural crest differentiation |
| REAC:R-HSA-1980143 | 0.000733987877666 | 0.375 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 |
| WP:WP4147 | 0.000859567015467 | 0.25 | NOTCH1 RBPJ | PTF1A related regulatory pathway |
| WP:WP3971 | 0.00107416462378 | 0.25 | NOTCH1 NOTCH2 | OSX and miRNAs in tooth development |
| KEGG:05224 | 0.00172091419679 | 0.375 | WNT2 NOTCH1 NOTCH2 | Breast cancer |
| WP:WP3678 | 0.00186035657619 | 0.25 | NOTCH1 WNT2 | Amplification and expansion of oncogenic pathways as metastatic traits |
| HP:0010760 | 0.0024024424666 | 0.375 | NOTCH1 NOTCH2 RBPJ | Absent toe |
| GO:0003205 | 0.00245296942189 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | cardiac chamber development |
| REAC:R-HSA-8878159 | 0.00245919645109 | 0.375 | MAML1 RBPJ NOTCH1 | Transcriptional regulation by RUNX3 |
| GO:0007219 | 0.00349206859402 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| WP:WP4262 | 0.00364116708552 | 0.375 | WNT2 NOTCH1 NOTCH2 | Breast cancer pathway |
| GO:0003177 | 0.0043754188034 | 0.375 | NOTCH1 NOTCH2 RBPJ | pulmonary valve development |
| REAC:R-HSA-1912420 | 0.00755574884395 | 0.25 | NOTCH1 NOTCH2 | Pre-NOTCH Processing in Golgi |
| GO:0048738 | 0.00766061600114 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | cardiac muscle tissue development |
| GO:0014706 | 0.00929268710366 | 0.5 | NOTCH2 MAML1 RBPJ NOTCH1 | striated muscle tissue development |
| WP:WP5269 | 0.00964105812378 | 0.25 | NOTCH1 RBPJ | Genetic causes of porto sinusoidal vascular disease |
| HP:0006493 | 0.0126987653037 | 0.5 | CCN6 NOTCH1 NOTCH2 RBPJ | Aplasia/hypoplasia involving bones of the lower limbs |
| WP:WP2848 | 0.0141059358228 | 0.25 | NOTCH1 WNT2 | Pluripotent stem cell differentiation pathway |
| HP:0009882 | 0.0142015381179 | 0.375 | NOTCH1 NOTCH2 RBPJ | Short distal phalanx of finger |
| HP:0009835 | 0.0164669703279 | 0.375 | NOTCH1 NOTCH2 RBPJ | Aplasia/Hypoplasia of the distal phalanges of the hand |
| HP:0001991 | 0.0169469260837 | 0.375 | NOTCH1 NOTCH2 RBPJ | Aplasia/Hypoplasia of toe |
| HP:0030966 | 0.0205674938424 | 0.375 | NOTCH1 NOTCH2 RBPJ | Abnormal pulmonary artery morphology |
| HP:0004414 | 0.0259270889741 | 0.375 | NOTCH1 NOTCH2 RBPJ | Abnormality of the pulmonary artery |
| GO:1905314 | 0.0265002084656 | 0.375 | NOTCH1 NOTCH2 RBPJ | semi-lunar valve development |
| HP:0004050 | 0.0306138099712 | 0.25 | NOTCH1 RBPJ | Absent hand |
| GO:0051149 | 0.0349415747767 | 0.375 | MAML1 NOTCH2 NOTCH1 | positive regulation of muscle cell differentiation |
| HP:0009832 | 0.0400990442176 | 0.375 | NOTCH1 NOTCH2 RBPJ | Abnormal distal phalanx morphology of finger |
| KEGG:01522 | 0.0421715550792 | 0.25 | NOTCH1 NOTCH2 | Endocrine resistance |
| HP:0001718 | 0.0427341718023 | 0.25 | NOTCH1 NOTCH2 | Mitral stenosis |
| REAC:R-HSA-3906995 | 0.0475081379956 | 0.25 | NOTCH1 NOTCH2 | Diseases associated with O-glycosylation of proteins |
| CORUM:2947 | 0.0499436884912 | 0.125 | NOTCH1 | YY1-Notch1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 0.998 | 0.076 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| RBPJ | NOTCH2 | 0.996 | 0.046 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| WNT2 | NOTCH1 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAML1 | NOTCH2 | 0.986 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| NOTCH1 | NOTCH2 | 0.981 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| NOTCH1 | RBPJ | 0.98 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| MAML1 | NOTCH1 | 0.979 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CCN6 | NOTCH1 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCN6 | NOTCH2 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WNT2 | NOTCH2 | 0.948 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IGFBP4 | NOTCH2 | 0.941 | 0.046 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| IGFBP4 | NOTCH1 | 0.933 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| ZNF783 | NOTCH2 | 0.889 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NOTCH2 | CRISPLD1 | 0.801 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ZNF783 | CRISPLD1 | 0.064 | bioplex3_WMM WMM_only | |
| ZNF783 | NOTCH1 | 0.044 | bioplex3_WMM WMM_only | |
| NOTCH1 | CRISPLD1 | 0.021 | bioplex3_WMM WMM_only |
Related Complexes