List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_11195.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
KIF26B	Kinesin-like protein KIF26B	4	UniProt   NCBI
CASK	Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)	5	UniProt   NCBI
PALS2	Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)	4	UniProt   NCBI
CRB3	Protein crumbs homolog 3	5	UniProt   NCBI
LIN7C	Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)	5	UniProt   NCBI
DLG1	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)	5	UniProt   NCBI
PATJ	InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions)	5	UniProt   NCBI
MPP7	MAGUK p55 subfamily member 7	5	UniProt   NCBI
ARHGEF26	Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)	5	UniProt   NCBI
MPDZ	Multiple PDZ domain protein (Multi-PDZ domain protein 1)	5	UniProt   NCBI
LIN7A	Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)	5	UniProt   NCBI
DLG4	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	5	UniProt   NCBI
MPP2	MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)	5	UniProt   NCBI
PXDC1	PX domain-containing protein 1	2	UniProt   NCBI
PALS1	Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)	5	UniProt   NCBI
LIN7B	Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)	5	UniProt   NCBI
MPP3	MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)	5	UniProt   NCBI
ABLIM2	Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)	5	UniProt   NCBI
APBA1	Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005911	1.11590176919e-15	0.736842105263	PALS1 MPP2 PALS2 CASK MPDZ LIN7C PATJ DLG1 MPP3 LIN7B CRB3 DLG4 LIN7A MPP7	cell-cell junction
GO:0045197	3.51527552528e-12	0.421052631579	PALS1 LIN7B LIN7C PATJ CRB3 DLG1 LIN7A DLG4	establishment or maintenance of epithelial cell apical/basal polarity
REAC:R-HSA-9609736	6.59817744475e-12	0.368421052632	APBA1 DLG1 LIN7B LIN7C CASK LIN7A DLG4	Assembly and cell surface presentation of NMDA receptors
GO:0035088	6.85438260213e-12	0.421052631579	PALS1 LIN7B LIN7C PATJ CRB3 DLG1 LIN7A DLG4	establishment or maintenance of apical/basal cell polarity
GO:0061245	6.85438260213e-12	0.421052631579	PALS1 LIN7B LIN7C PATJ CRB3 DLG1 LIN7A DLG4	establishment or maintenance of bipolar cell polarity
GO:0070161	2.21109643879e-11	0.736842105263	PALS1 MPP2 PALS2 CASK MPDZ LIN7C PATJ DLG1 MPP3 LIN7B CRB3 DLG4 LIN7A MPP7	anchoring junction
CORUM:3207	7.78532502225e-11	0.210526315789	CASK APBA1 LIN7A DLG1	LIN2-LIN7-SAP97-MINT1 complex
GO:0097025	1.04703057072e-10	0.263157894737	DLG1 LIN7B LIN7C LIN7A MPP7	MPP7-DLG1-LIN7 complex
REAC:R-HSA-6794362	6.12459759277e-10	0.368421052632	APBA1 DLG1 LIN7B LIN7C CASK LIN7A DLG4	Protein-protein interactions at synapses
REAC:R-HSA-442755	1.61133272242e-09	0.368421052632	APBA1 DLG1 LIN7B LIN7C CASK LIN7A DLG4	Activation of NMDA receptors and postsynaptic events
GO:0030054	3.90047893296e-09	0.789473684211	PALS1 MPP2 PALS2 CASK MPDZ LIN7C PATJ DLG1 MPP3 LIN7B CRB3 DLG4 LIN7A MPP7 APBA1	cell junction
CORUM:848	5.43184552607e-09	0.210526315789	PALS1 MPDZ PATJ MPP7	RICH1/AMOT polarity complex, Flag-Amot precipitated
REAC:R-HSA-6794361	5.45816011903e-09	0.315789473684	APBA1 LIN7B LIN7C CASK LIN7A DLG4	Neurexins and neuroligins
GO:0007163	6.01084516021e-09	0.473684210526	PALS1 LIN7B LIN7C PATJ CRB3 DLG1 DLG4 LIN7A MPP7	establishment or maintenance of cell polarity
REAC:R-HSA-212676	1.25960226141e-08	0.263157894737	CASK APBA1 LIN7C LIN7B LIN7A	Dopamine Neurotransmitter Release Cycle
GO:0098590	3.26513287318e-08	0.631578947368	PALS1 MPP2 CASK MPDZ LIN7C PATJ CRB3 DLG1 MPP3 LIN7B DLG4 LIN7A	plasma membrane region
CORUM:1448	7.10994807657e-08	0.157894736842	CASK LIN7A DLG1	LIN2-LIN7-SAP97 complex
CORUM:6263	7.10994807657e-08	0.157894736842	DLG1 LIN7C MPP7	MPP7-DLG1-LIN7C complex
CORUM:6260	7.10994807657e-08	0.157894736842	DLG1 MPP7 LIN7A	MPP7-DLG1-LIN7A complex
CORUM:617	7.10994807657e-08	0.157894736842	CASK LIN7C APBA1	CASK-LIN7C-APBA1 complex
GO:0097016	1.01987757791e-07	0.210526315789	DLG1 LIN7C LIN7B LIN7A	L27 domain binding
GO:0005912	1.24257805205e-07	0.421052631579	PALS1 MPP3 LIN7B LIN7C DLG1 LIN7A DLG4 MPP7	adherens junction
REAC:R-HSA-112314	2.04339731648e-07	0.368421052632	APBA1 DLG1 LIN7B LIN7C CASK LIN7A DLG4	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-112310	3.06507319202e-07	0.263157894737	CASK APBA1 LIN7C LIN7B LIN7A	Neurotransmitter release cycle
REAC:R-HSA-112315	1.17806396793e-06	0.368421052632	APBA1 DLG1 LIN7B LIN7C CASK LIN7A DLG4	Transmission across Chemical Synapses
REAC:R-HSA-9705677	5.56810784361e-06	0.157894736842	PALS1 CRB3 PATJ	SARS-CoV-2 targets PDZ proteins in cell-cell junction
REAC:R-HSA-112316	1.67020759568e-05	0.368421052632	APBA1 DLG1 LIN7B LIN7C CASK LIN7A DLG4	Neuronal System
GO:0043296	2.84918372303e-05	0.315789473684	PALS1 MPDZ CRB3 PATJ DLG1 MPP7	apical junction complex
KEGG:04530	4.40222084869e-05	0.263157894737	PALS1 DLG1 MPDZ CRB3 PATJ	Tight junction
CORUM:3209	6.11162772017e-05	0.105263157895	CASK DLG1	LIN2-SAP97 complex
CORUM:1089	6.11162772017e-05	0.105263157895	LIN7A PALS2	VAM1-VELI1 complex
CORUM:3208	6.11162772017e-05	0.105263157895	CASK LIN7A	LIN2-LIN7 complex
CORUM:460	0.000183206632644	0.105263157895	PALS1 PATJ	CRB1-MPP5-INADL complex
REAC:R-HSA-420029	0.000251275971072	0.157894736842	PALS1 CRB3 PATJ	Tight junction interactions
GO:0007268	0.000320683487829	0.421052631579	APBA1 DLG1 MPP2 LIN7C CASK LIN7B LIN7A DLG4	chemical synaptic transmission
GO:0098916	0.000320683487829	0.421052631579	APBA1 DLG1 MPP2 LIN7C CASK LIN7B LIN7A DLG4	anterograde trans-synaptic signaling
GO:0099537	0.000350292794195	0.421052631579	APBA1 DLG1 MPP2 LIN7C CASK LIN7B LIN7A DLG4	trans-synaptic signaling
WP:WP5417	0.000507401467759	0.210526315789	DLG4 CASK LIN7A DLG1	Cell lineage map for neuronal differentiation
GO:0099536	0.000547914857369	0.421052631579	APBA1 DLG1 MPP2 LIN7C CASK LIN7B LIN7A DLG4	synaptic signaling
GO:0019904	0.000713541381133	0.421052631579	PALS1 LIN7B CRB3 LIN7C DLG1 LIN7A DLG4 MPP7	protein domain specific binding
GO:0016323	0.000713801390064	0.315789473684	DLG1 LIN7B LIN7C CASK LIN7A DLG4	basolateral plasma membrane
GO:0009925	0.00156323391717	0.315789473684	DLG1 LIN7B LIN7C CASK LIN7A DLG4	basal plasma membrane
CORUM:846	0.00170330895109	0.105263157895	PALS1 PATJ	RICH1/AMOT polarity complex, Flag-Rich1 precipitated
KEGG:04390	0.00191872640433	0.210526315789	PALS1 DLG1 PATJ DLG4	Hippo signaling pathway
GO:0045178	0.00203539119391	0.315789473684	DLG1 LIN7B LIN7C CASK LIN7A DLG4	basal part of cell
REAC:R-HSA-1500931	0.00248893642493	0.210526315789	PALS1 CASK CRB3 PATJ	Cell-Cell communication
GO:1903361	0.0032492156641	0.157894736842	LIN7A LIN7C LIN7B	protein localization to basolateral plasma membrane
REAC:R-HSA-451306	0.00478300571463	0.105263157895	DLG1 DLG4	Ionotropic activity of kainate receptors
REAC:R-HSA-451308	0.00478300571463	0.105263157895	DLG1 DLG4	Activation of Ca-permeable Kainate Receptor
GO:0045199	0.00519447563198	0.157894736842	LIN7A LIN7C LIN7B	maintenance of epithelial cell apical/basal polarity
GO:0035090	0.00519447563198	0.157894736842	LIN7A LIN7C LIN7B	maintenance of apical/basal cell polarity
REAC:R-HSA-421270	0.00764570993944	0.157894736842	PALS1 CRB3 PATJ	Cell-cell junction organization
GO:0045202	0.00798267963977	0.421052631579	APBA1 DLG1 MPP2 LIN7C CASK LIN7B LIN7A DLG4	synapse
REAC:R-HSA-447038	0.0100287404991	0.105263157895	DLG1 DLG4	NrCAM interactions
GO:0005886	0.0111431081769	0.789473684211	PALS1 MPP2 PALS2 CASK MPDZ LIN7C PATJ DLG1 MPP3 LIN7B CRB3 DLG4 LIN7A MPP7 APBA1	plasma membrane
GO:0120192	0.0175592756753	0.210526315789	DLG1 MPDZ PATJ MPP7	tight junction assembly
GO:0120193	0.0208240097662	0.210526315789	DLG1 MPDZ PATJ MPP7	tight junction organization
KEGG:05165	0.0285119170386	0.210526315789	PALS1 DLG1 CRB3 PATJ	Human papillomavirus infection
REAC:R-HSA-446728	0.0314296506547	0.157894736842	PALS1 CRB3 PATJ	Cell junction organization
GO:0030011	0.0335980618564	0.157894736842	LIN7A LIN7C LIN7B	maintenance of cell polarity
GO:1990778	0.0357479287284	0.315789473684	PALS1 LIN7B CRB3 LIN7C DLG1 LIN7A	protein localization to cell periphery
GO:0005923	0.0413913773049	0.210526315789	DLG1 MPDZ PATJ MPP7	bicellular tight junction
GO:0071944	0.0431156650101	0.789473684211	PALS1 MPP2 PALS2 CASK MPDZ LIN7C PATJ DLG1 MPP3 LIN7B CRB3 DLG4 LIN7A MPP7 APBA1	cell periphery
REAC:R-HSA-442982	0.0432225789502	0.105263157895	DLG1 DLG4	Ras activation upon Ca2+ influx through NMDA receptor
GO:0072657	0.0437599409249	0.368421052632	PALS1 LIN7B CRB3 LIN7C DLG1 LIN7A DLG4	protein localization to membrane
CORUM:1909	0.0496196263904	0.0526315789474	DLG4	APC-DLG4 complex
CORUM:6321	0.0496196263904	0.0526315789474	DLG4	DLG4-DLGAP1-SHANK3 complex
CORUM:4869	0.0496196263904	0.0526315789474	DLG1	beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A)



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
PALS1	LIN7C	1.0	0.052
LIN7C	PALS2	1.0	0.086
LIN7A	MPP2	1.0
LIN7B	MPP2	1.0
DLG1	LIN7C	1.0
LIN7C	MPP2	1.0
PALS2	MPP2	1.0
PALS1	LIN7B	1.0
MPP7	LIN7C	0.999	0.078
DLG1	MPP2	0.999
APBA1	CASK	0.999
CRB3	PALS1	0.999
CASK	LIN7C	0.999
APBA1	DLG1	0.999
APBA1	LIN7C	0.999	0.098
MPP3	LIN7C	0.998
PXDC1	LIN7C	0.998	0.17
DLG1	LIN7B	0.997
CASK	LIN7B	0.997
APBA1	LIN7B	0.997
CASK	DLG1	0.997
ARHGEF26	LIN7C	0.996	0.09
LIN7B	LIN7C	0.996
PALS1	MPDZ	0.996	0.052
DLG1	MPP7	0.996
CASK	MPP7	0.995
MPP7	LIN7B	0.995
LIN7B	PALS2	0.995
MPDZ	LIN7C	0.994	0.008
PXDC1	LIN7B	0.994
KIF26B	LIN7C	0.994	0.124
APBA1	PXDC1	0.993	0.13
MPP3	LIN7B	0.991
CASK	PXDC1	0.991
LIN7A	PALS1	0.99	0.116
LIN7A	PALS2	0.987	0.054
CASK	PALS2	0.984
KIF26B	MPP7	0.984	0.102
DLG4	LIN7C	0.982	0.178
PALS1	MPP7	0.982	0.096
APBA1	DLG4	0.981	0.106
MPDZ	LIN7B	0.981
CRB3	LIN7C	0.978
PALS1	PALS2	0.974	0.05
LIN7A	APBA1	0.974	0.152
APBA1	MPP3	0.967
MPP3	PXDC1	0.967
KIF26B	DLG1	0.967
MPP7	PALS2	0.966	0.132
PALS1	MPP3	0.963
MPP3	CASK	0.96
MPP3	MPP2	0.958
MPP3	MPP7	0.958
MPP3	DLG1	0.958
ARHGEF26	APBA1	0.954	0.242
MPP3	PALS2	0.951
PXDC1	DLG1	0.95
LIN7C	ABLIM2	0.948
KIF26B	LIN7B	0.937
PALS1	CASK	0.934
ARHGEF26	DLG1	0.93
PALS1	DLG1	0.928
MPP7	MPP2	0.917
CASK	MPP2	0.914
ARHGEF26	MPP3	0.908
LIN7A	MPDZ	0.907	0.044
PALS1	MPP2	0.904
CRB3	ABLIM2	0.902
DLG4	MPP3	0.902
DLG4	CRB3	0.902
CRB3	MPP3	0.902
DLG4	ABLIM2	0.902
APBA1	MPP7	0.898	0.088
PALS1	PXDC1	0.895	0.102
APBA1	MPP2	0.895
APBA1	PALS1	0.895	0.094
APBA1	PALS2	0.893	0.052
PXDC1	MPP7	0.888	0.082
PXDC1	MPP2	0.885
MPDZ	MPP7	0.88	0.06
KIF26B	CASK	0.88
PXDC1	PALS2	0.879	0.1
ARHGEF26	LIN7B	0.873
LIN7A	LIN7C	0.853	0.142
DLG1	PALS2	0.85
ARHGEF26	PXDC1	0.849	0.176
ARHGEF26	CASK	0.849
MPDZ	PALS2	0.812	0.02
MPP3	ABLIM2	0.8
MPDZ	DLG1	0.794
ARHGEF26	MPP7	0.776	0.25
ARHGEF26	ABLIM2	0.761
ARHGEF26	PALS1	0.749	0.108
ARHGEF26	PALS2	0.742	0.124
ARHGEF26	MPP2	0.723
APBA1	CRB3	0.717
CRB3	PXDC1	0.717
ARHGEF26	CRB3	0.696
KIF26B	PXDC1	0.691	0.064
PXDC1	ABLIM2	0.675
APBA1	ABLIM2	0.675
MPP7	ABLIM2	0.646
MPP2	ABLIM2	0.646
MPDZ	CASK	0.644
ARHGEF26	DLG4	0.642	0.184
DLG4	LIN7B	0.64
PALS2	ABLIM2	0.634
CASK	ABLIM2	0.634
DLG1	ABLIM2	0.634
DLG4	DLG1	0.633
DLG4	CASK	0.633
LIN7A	LIN7B	0.63
DLG4	PXDC1	0.616	0.096
PALS1	ABLIM2	0.613
LIN7A	DLG1	0.606
MPP3	KIF26B	0.583
APBA1	KIF26B	0.566	0.068
ARHGEF26	KIF26B	0.466	0.136
CRB3	CASK	0.459
CRB3	MPP2	0.45
DLG4	MPP7	0.45	0.096
CRB3	MPP7	0.45
DLG4	MPP2	0.45
LIN7A	CASK	0.449
CRB3	DLG1	0.437
DLG4	PALS1	0.427	0.044
MPDZ	MPP3	0.401
CRB3	PALS2	0.388
DLG4	PALS2	0.388	0.078
MPDZ	MPP2	0.378
MPDZ	KIF26B	0.357	0.048
ARHGEF26	MPDZ	0.357	0.136
KIF26B	MPP2	0.357
APBA1	MPDZ	0.357	0.054
PALS1	KIF26B	0.357	0.102
MPDZ	PXDC1	0.357	0.044
LIN7A	DLG4	0.356	0.104
KIF26B	PALS2	0.353	0.074
CRB3	LIN7B	0.352
LIN7A	PXDC1	0.332	0.05
KIF26B	ABLIM2	0.313
CRB3	MPDZ	0.303
LIN7A	CRB3	0.225
CRB3	KIF26B	0.214
DLG4	KIF26B	0.214	0.186
MPDZ	ABLIM2	0.193
LIN7B	ABLIM2	0.193
DLG4	MPDZ	0.131	0.05
LIN7A	MPP7	0.079	0.054
ARHGEF26	LIN7A	0.022	0.176





Related Complexes

Genename	Complexes
KIF26B	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
CASK	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
PALS2	huMAP3_05314.1 huMAP3_06839.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_10716.1 huMAP3_11195.1 huMAP3_14575.1
CRB3	huMAP3_03320.1 huMAP3_04256.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_10760.1 huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
LIN7C	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
DLG1	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
PATJ	huMAP3_05036.1 huMAP3_06620.1 huMAP3_07872.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
MPP7	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
ARHGEF26	huMAP3_00174.1 huMAP3_08198.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
MPDZ	huMAP3_04256.1 huMAP3_07106.1 huMAP3_07872.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
LIN7A	huMAP3_00243.1 huMAP3_05314.1 huMAP3_06839.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_10716.1 huMAP3_11195.1 huMAP3_14575.1
DLG4	huMAP3_00243.1 huMAP3_05036.1 huMAP3_05627.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
MPP2	huMAP3_05314.1 huMAP3_06839.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_10716.1 huMAP3_11195.1 huMAP3_14575.1
PXDC1	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
PALS1	huMAP3_03320.1 huMAP3_04256.1 huMAP3_07106.1 huMAP3_07872.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_10760.1 huMAP3_11195.1 huMAP3_14575.1
LIN7B	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
MPP3	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
ABLIM2	huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
APBA1	huMAP3_00243.1 huMAP3_05627.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1