hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11199.1

Complex Portal: CPX-12888

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CCNL1	Cyclin-L1 (Cyclin-L)	5	UniProt NCBI
NKAPL	NKAP-like protein	4	UniProt NCBI
CSNK2A2	Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)	5	UniProt NCBI
HIRIP3	HIRA-interacting protein 3	5	UniProt NCBI
CDK11B	Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)	5	UniProt NCBI
CSNK2A1	Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)	5	UniProt NCBI
GPATCH2	G patch domain-containing protein 2	5	UniProt NCBI
CSNK2B	Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2720	7.02338504734e-09	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Casein kinase II (beta-dimer, alpha, alpha')
CORUM:5224	7.02338504734e-09	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Casein kinase II (beta-dimer, alpha, alpha')
CORUM:2719	2.80877722849e-08	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Casein kinase II-HMG1 complex
CORUM:938	7.02050133195e-08	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	FACT complex, UV-activated
REAC:R-HSA-201688	7.29464907751e-07	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	WNT mediated activation of DVL
REAC:R-HSA-8934903	7.29464907751e-07	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Receptor Mediated Mitophagy
REAC:R-HSA-2514853	2.1479923589e-06	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Condensation of Prometaphase Chromosomes
GO:0005956	3.36420143768e-06	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	protein kinase CK2 complex
REAC:R-HSA-445144	8.84142817265e-06	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Signal transduction by L1
CORUM:5225	2.05265451394e-05	0.285714285714	CSNK2A1 CSNK2B	Casein kinase II (beta-dimer, alpha-dimer)
CORUM:5223	2.05265451394e-05	0.285714285714	CSNK2B CSNK2A2	Casein kinase II (beta-dimer, alpha'-dimer)
REAC:R-HSA-1483191	2.29983491089e-05	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Synthesis of PC
REAC:R-HSA-5205647	3.374300022e-05	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Mitophagy
REAC:R-HSA-6814122	8.47845144152e-05	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
REAC:R-HSA-8939243	9.24731829377e-05	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
KEGG:03008	0.000215291990588	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Ribosome biogenesis in eukaryotes
KEGG:04064	0.000283987845873	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	NF-kappa B signaling pathway
KEGG:05235	0.000283987845873	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	PD-L1 expression and PD-1 checkpoint pathway in cancer
KEGG:04520	0.000353303499329	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Adherens junction
WP:WP4336	0.000389348265612	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
KEGG:04137	0.00052377688541	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Mitophagy - animal
WP:WP4258	0.000550836976424	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	lncRNA in canonical Wnt signaling and colorectal cancer
REAC:R-HSA-8948751	0.000644814393069	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Regulation of PTEN stability and activity
REAC:R-HSA-9663891	0.000867554862533	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Selective autophagy
WP:WP428	0.000995386406049	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Wnt signaling
KEGG:05162	0.00106227049151	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Measles
REAC:R-HSA-390466	0.00126637654584	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Chaperonin-mediated protein folding
REAC:R-HSA-6804756	0.00145485785287	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Regulation of TP53 Activity through Phosphorylation
REAC:R-HSA-391251	0.00160779946306	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Protein folding
WP:WP4630	0.00179934668905	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Measles virus infection
KEGG:04310	0.00187826319582	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Wnt signaling pathway
REAC:R-HSA-373760	0.00219374690011	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	L1CAM interactions
WP:WP4262	0.00227439079054	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Breast cancer pathway
REAC:R-HSA-9755511	0.0023257157346	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	KEAP1-NFE2L2 pathway
REAC:R-HSA-1483206	0.00239362555724	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Glycerophospholipid biosynthesis
REAC:R-HSA-1632852	0.00413825544794	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Macroautophagy
REAC:R-HSA-6807070	0.0050886020956	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	PTEN Regulation
REAC:R-HSA-9612973	0.00579605132299	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Autophagy
REAC:R-HSA-5633007	0.00725596819608	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Regulation of TP53 Activity
KEGG:05020	0.00808797926109	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Prion disease
GO:1902554	0.00903437394907	0.571428571429	CSNK2B CCNL1 CSNK2A2 CSNK2A1	serine/threonine protein kinase complex
REAC:R-HSA-1483257	0.0112390395008	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Phospholipid metabolism
WP:WP2059	0.0117907139106	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Alzheimer 39 s disease and miRNA effects
WP:WP5124	0.0117907139106	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Alzheimer 39 s disease
REAC:R-HSA-9711123	0.0126241322329	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Cellular response to chemical stress
GO:1902911	0.0150328542879	0.571428571429	CSNK2B CCNL1 CSNK2A2 CSNK2A1	protein kinase complex
REAC:R-HSA-68877	0.015251615709	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Mitotic Prometaphase
REAC:R-HSA-201681	0.0182152367353	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	TCF dependent signaling in response to WNT
REAC:R-HSA-8878171	0.0192810955771	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Transcriptional regulation by RUNX1
KEGG:05010	0.0212667141862	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Alzheimer disease
REAC:R-HSA-1257604	0.0249041859614	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	PIP3 activates AKT signaling
GO:0075342	0.0294899169624	0.285714285714	CSNK2A1 CSNK2B	symbiont-mediated disruption of host cell PML body
GO:0052111	0.0294899169624	0.285714285714	CSNK2A1 CSNK2B	symbiont-mediated disruption of host anatomical structure
GO:0052008	0.0294899169624	0.285714285714	CSNK2A1 CSNK2B	symbiont-mediated disruption of host cellular anatomical entity
KEGG:05022	0.0378661997772	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Pathways of neurodegeneration - multiple diseases
REAC:R-HSA-9006925	0.0378815015202	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Intracellular signaling by second messengers
GO:0031519	0.0383127531327	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	PcG protein complex
WP:WP5087	0.0480568023702	0.428571428571	CSNK2A1 CSNK2A2 CSNK2B	Pleural mesothelioma

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CSNK2A1	CSNK2B	1.0	0.962		hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
CSNK2A2	CSNK2A1	1.0	0.704		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
CSNK2A2	CSNK2B	1.0	0.842		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
CCNL1	CDK11B	0.999	0.299		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CSNK2A2	HIRIP3	0.998	0.086	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
HIRIP3	CSNK2A1	0.997	0.118		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
HIRIP3	CSNK2B	0.994	0.138		bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CSNK2B	CCNL1	0.991	0.154		bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CSNK2A1	CCNL1	0.989	0.114		hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CSNK2A2	GPATCH2	0.987	0.13		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
CSNK2A2	CCNL1	0.979	0.096		bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CSNK2A2	CDK11B	0.971	0.21		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein ()
CSNK2B	CDK11B	0.94	0.236		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CSNK2B	GPATCH2	0.931	0.16		bioplex3_HEK293 bioplex3_WMM boldt_WMM WMM_only
CSNK2A1	CDK11B	0.862	0.33		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NKAPL	CSNK2A1	0.858			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
NKAPL	CSNK2A2	0.854			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
CSNK2A1	GPATCH2	0.853	0.112		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only
NKAPL	CSNK2B	0.731			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
HIRIP3	GPATCH2	0.364	0.148		bioplex_WMM bioplex3_WMM WMM_only
CDK11B	GPATCH2	0.353	0.13		bioplex_WMM bioplex3_WMM WMM_only
HIRIP3	CDK11B	0.352	0.108		bioplex_WMM bioplex3_WMM WMM_only
HIRIP3	CCNL1	0.268	0.092		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CCNL1	GPATCH2	0.106	0.122		bioplex3_WMM WMM_only
NKAPL	CCNL1	0.022			youn_WMM WMM_only

Related Complexes

Genename	Complexes
CCNL1	huMAP3_02101.1 huMAP3_11199.1 huMAP3_14373.1 huMAP3_14389.1 huMAP3_14605.1
NKAPL	huMAP3_01240.1 huMAP3_03111.1 huMAP3_03128.1 huMAP3_06342.1 huMAP3_08212.1 huMAP3_08452.1 huMAP3_08493.1 huMAP3_08715.1 huMAP3_09303.1 huMAP3_09368.1 huMAP3_09607.1 huMAP3_10010.1 huMAP3_10250.1 huMAP3_10469.1 huMAP3_11199.1 huMAP3_14051.1 huMAP3_14425.1
CSNK2A2	huMAP3_01759.1 huMAP3_06386.1 huMAP3_10162.1 huMAP3_11199.1 huMAP3_14051.1 huMAP3_14425.1
HIRIP3	huMAP3_01759.1 huMAP3_04264.1 huMAP3_06386.1 huMAP3_10162.1 huMAP3_11199.1 huMAP3_14051.1
CDK11B	huMAP3_02101.1 huMAP3_11199.1
CSNK2A1	huMAP3_01759.1 huMAP3_06386.1 huMAP3_06487.1 huMAP3_07124.1 huMAP3_08452.1 huMAP3_09368.1 huMAP3_09943.1 huMAP3_10010.1 huMAP3_10162.1 huMAP3_10250.1 huMAP3_11199.1 huMAP3_14051.1
GPATCH2	huMAP3_03741.1 huMAP3_08327.1 huMAP3_08616.1 huMAP3_08925.1 huMAP3_11199.1 huMAP3_13063.1 huMAP3_13651.1 huMAP3_14051.1
CSNK2B	huMAP3_01759.1 huMAP3_06386.1 huMAP3_10162.1 huMAP3_11199.1 huMAP3_14051.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11199.1

Complex Portal: CPX-12888