hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11209.1
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
RBMXL3 | RNA-binding motif protein, X-linked-like-3 | 2 | UniProt   NCBI |
CACNB4 | Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4) | 5 | UniProt   NCBI |
ZFY | Zinc finger Y-chromosomal protein | 5 | UniProt   NCBI |
CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | 5 | UniProt   NCBI |
CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | 5 | UniProt   NCBI |
CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-112308 | 5.07705636973e-11 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Presynaptic depolarization and calcium channel opening |
  REAC:R-HSA-419037 | 2.5402076735e-08 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | NCAM1 interactions |
  REAC:R-HSA-375165 | 1.61742470164e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | NCAM signaling for neurite out-growth |
  WP:WP2118 | 2.56173883411e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Arrhythmogenic right ventricular cardiomyopathy |
  KEGG:05412 | 3.30414614276e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Arrhythmogenic right ventricular cardiomyopathy |
  GO:0008331 | 3.94651622678e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | high voltage-gated calcium channel activity |
  KEGG:04260 | 4.17220190946e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Cardiac muscle contraction |
  KEGG:05414 | 5.20074832828e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Dilated cardiomyopathy |
  KEGG:05410 | 5.20074832828e-07 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Hypertrophic cardiomyopathy |
  GO:0007528 | 2.88146527749e-06 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | neuromuscular junction development |
  KEGG:04921 | 3.09636971273e-06 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Oxytocin signaling pathway |
  KEGG:04261 | 3.20371655146e-06 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Adrenergic signaling in cardiomyocytes |
  GO:0005245 | 1.23822125661e-05 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated calcium channel activity |
  GO:0005891 | 1.60994442835e-05 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated calcium channel complex |
  WP:WP382 | 3.65710878533e-05 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | MAPK signaling pathway |
  KEGG:04010 | 5.63999263147e-05 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | MAPK signaling pathway |
  REAC:R-HSA-112315 | 9.75067714909e-05 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Transmission across Chemical Synapses |
  GO:0034704 | 9.81259188038e-05 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium channel complex |
  GO:1990454 | 0.000161332517231 | 0.5 | CACNB2 CACNB1 CACNB3 | L-type voltage-gated calcium channel complex |
  GO:0005262 | 0.000450665620324 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium channel activity |
  REAC:R-HSA-112316 | 0.000452345664425 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Neuronal System |
  GO:0022843 | 0.000684451996602 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated monoatomic cation channel activity |
  GO:0061577 | 0.000698569295426 | 0.5 | CACNB2 CACNB1 CACNB3 | calcium ion transmembrane transport via high voltage-gated calcium channel |
  GO:0015085 | 0.000999031924798 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium ion transmembrane transporter activity |
  REAC:R-HSA-5576893 | 0.00116019984728 | 0.333333333333 | CACNB2 CACNB1 | Phase 2 - plateau phase |
  GO:1903169 | 0.00129796765781 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of calcium ion transmembrane transport |
  GO:0022832 | 0.00147034444981 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated channel activity |
  GO:0005244 | 0.00147034444981 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated monoatomic ion channel activity |
  GO:1901385 | 0.00185822071527 | 0.5 | CACNB2 CACNB4 CACNB3 | regulation of voltage-gated calcium channel activity |
  REAC:R-HSA-422475 | 0.0030564769327 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Axon guidance |
  REAC:R-HSA-9675108 | 0.00353370301704 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Nervous system development |
  GO:0034703 | 0.00442159197262 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | cation channel complex |
  GO:0051924 | 0.00562498219933 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of calcium ion transport |
  REAC:R-HSA-400042 | 0.00594265866298 | 0.333333333333 | CACNB2 CACNB3 | Adrenaline,noradrenaline inhibits insulin secretion |
  REAC:R-HSA-5576892 | 0.0070977267476 | 0.333333333333 | CACNB2 CACNB1 | Phase 0 - rapid depolarisation |
  GO:0030315 | 0.00949259421943 | 0.5 | CACNB2 CACNB1 CACNB3 | T-tubule |
  GO:0034702 | 0.0121174468054 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | monoatomic ion channel complex |
  GO:0022836 | 0.0156557881857 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | gated channel activity |
  WP:WP5356 | 0.0159206501541 | 0.333333333333 | CACNB2 CACNB1 | Affected pathways in Duchenne muscular dystrophy |
  GO:0070588 | 0.0167421435431 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium ion transmembrane transport |
  GO:1904062 | 0.0167421435431 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of monoatomic cation transmembrane transport |
  GO:0034765 | 0.0244885464925 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of monoatomic ion transmembrane transport |
  GO:0005261 | 0.0249855480901 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | monoatomic cation channel activity |
  REAC:R-HSA-1266738 | 0.02903341132 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | Developmental Biology |
  GO:0050808 | 0.0372717918379 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | synapse organization |
  GO:0010959 | 0.0386403705075 | 0.666666666667 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of metal ion transport |
  GO:1901843 | 0.042122686785 | 0.333333333333 | CACNB2 CACNB3 | positive regulation of high voltage-gated calcium channel activity |
  GO:1901019 | 0.0473097913612 | 0.5 | CACNB2 CACNB4 CACNB3 | regulation of calcium ion transmembrane transporter activity |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
---|---|---|---|---|
 CACNB3 |  CACNB2 | 0.999 |            | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     |
 CACNB3 |  CACNB1 | 0.999 |            | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     |
 RBMXL3 |  CACNB1 | 0.998 |            | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 CACNB2 |  CACNB1 | 0.997 |            | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     |
 CACNB4 |  CACNB3 | 0.995 |            | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     |
 CACNB3 |  RBMXL3 | 0.904 |            | bioplex3_WMM     WMM_only     |
 CACNB4 |  CACNB2 | 0.902 |            | bioplex3_WMM     WMM_only     |
 CACNB3 |  ZFY | 0.843 |            | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     |
 CACNB2 |  RBMXL3 | 0.214 |            | bioplex3_WMM     WMM_only     |
Related Complexes