hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11220.1
Complex Portal: CPX-17589
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FHIP1B | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | 5 | UniProt NCBI |
| HOOK3 | Protein Hook homolog 3 (h-hook3) (hHK3) | 5 | UniProt NCBI |
| AKTIP | AKT-interacting protein (Ft1) (Fused toes protein homolog) | 5 | UniProt NCBI |
| CTIF | CBP80/20-dependent translation initiation factor | 5 | UniProt NCBI |
| HOOK1 | Protein Hook homolog 1 (h-hook1) (hHK1) | 5 | UniProt NCBI |
| FHIP1A | FHF complex subunit HOOK-interacting protein 1A (FHIP1A) (FTS- and Hook-interacting protein like) (FHIP-L) | 3 | UniProt NCBI |
| NAB1 | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6109 | 9.61159511016e-12 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | FHF complex |
| GO:1905719 | 2.38147473756e-11 | 0.714285714286 | AKTIP FHIP1A FHIP1B HOOK1 HOOK3 | protein localization to perinuclear region of cytoplasm |
| GO:0070695 | 4.60395405777e-09 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | FHF complex |
| GO:0045022 | 6.76004009067e-05 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | early endosome to late endosome transport |
| GO:0098927 | 0.000102438985779 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | vesicle-mediated transport between endosomal compartments |
| GO:0008333 | 0.000335372025083 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | endosome to lysosome transport |
| GO:0030897 | 0.000738757615619 | 0.428571428571 | AKTIP HOOK3 HOOK1 | HOPS complex |
| GO:0007032 | 0.00151291269338 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | endosome organization |
| GO:0007040 | 0.00159023569175 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | lysosome organization |
| GO:0080171 | 0.00159023569175 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | lytic vacuole organization |
| GO:0007041 | 0.00449874442284 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | lysosomal transport |
| GO:0007034 | 0.0108952763413 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | vacuolar transport |
| GO:0007033 | 0.0386866758686 | 0.571428571429 | AKTIP FHIP1B HOOK1 HOOK3 | vacuole organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HOOK3 | AKTIP | 1.0 | 0.122 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| AKTIP | HOOK1 | 1.0 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| FHIP1B | AKTIP | 1.0 | 0.236 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| FHIP1B | HOOK3 | 0.999 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| AKTIP | NAB1 | 0.999 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AKTIP | FHIP1A | 0.999 | 0.108 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HOOK3 | HOOK1 | 0.998 | 0.072 |
mutually_exclusive (Q9H8T0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| HOOK3 | FHIP1A | 0.997 | 0.066 |
mutually_exclusive (Q9H8T0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| FHIP1B | HOOK1 | 0.987 | 0.082 |
mutually_exclusive (Q9H8T0)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| FHIP1B | FHIP1A | 0.966 | 0.12 |
mutually_exclusive (Q9H8T0)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CTIF | HOOK1 | 0.956 | 0.142 | youn () bioplex3_WMM youn_WMM WMM_only | |
| CTIF | HOOK3 | 0.945 | 0.198 | youn () youn_WMM WMM_only | |
| CTIF | AKTIP | 0.935 | 0.15 | youn () youn_WMM WMM_only | |
| HOOK1 | FHIP1A | 0.927 | 0.086 |
mutually_exclusive (Q9H8T0)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| FHIP1A | NAB1 | 0.923 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| HOOK3 | NAB1 | 0.906 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTIF | FHIP1A | 0.889 | 0.104 | youn () youn_WMM WMM_only | |
| FHIP1B | NAB1 | 0.851 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| HOOK1 | NAB1 | 0.839 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTIF | FHIP1B | 0.074 | 0.12 | youn () youn_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| FHIP1B | huMAP3_03865.1 huMAP3_11220.1 |
| HOOK3 | huMAP3_03865.1 huMAP3_11220.1 |
| AKTIP | huMAP3_03865.1 huMAP3_11220.1 |
| CTIF | huMAP3_01753.1 huMAP3_11220.1 huMAP3_14521.1 |
| HOOK1 | huMAP3_03865.1 huMAP3_11220.1 |
| FHIP1A | huMAP3_03865.1 huMAP3_11220.1 |
| NAB1 | huMAP3_04646.1 huMAP3_08021.1 huMAP3_09084.1 huMAP3_11220.1 |