hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11222.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRIM1 | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | 5 | UniProt NCBI |
| BTF3 | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | 5 | UniProt NCBI |
| NACA2 | Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like) | 4 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| PRIM2 | DNA primase large subunit (DNA primase 58 kDa subunit) (p58) | 5 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 1.87066161015e-08 | 0.5 | PRIM1 POLA2 PRIM2 | DNA polymerase alpha-primase complex |
| CORUM:1107 | 3.92536538276e-07 | 0.5 | PRIM1 POLA2 PRIM2 | DNA synthesome core complex |
| REAC:R-HSA-68952 | 3.95483747683e-07 | 0.5 | PRIM1 POLA2 PRIM2 | DNA replication initiation |
| CORUM:1098 | 5.6068011168e-07 | 0.5 | PRIM1 POLA2 PRIM2 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 1.33567017806e-06 | 0.5 | PRIM1 POLA2 PRIM2 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 1.69968198401e-06 | 0.5 | PRIM1 POLA2 PRIM2 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.69968198401e-06 | 0.5 | PRIM1 POLA2 PRIM2 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-113501 | 2.01823692347e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-174430 | 2.01823692347e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-69166 | 2.56826946848e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Removal of the Flap Intermediate |
| REAC:R-HSA-69091 | 2.56826946848e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Polymerase switching |
| REAC:R-HSA-69109 | 2.56826946848e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Leading Strand Synthesis |
| REAC:R-HSA-69183 | 3.20984225624e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 8.03604834368e-06 | 0.5 | PRIM1 POLA2 PRIM2 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 1.08523688914e-05 | 0.5 | PRIM1 POLA2 PRIM2 | E2F mediated regulation of DNA replication |
| KEGG:03030 | 1.41369735506e-05 | 0.5 | PRIM1 POLA2 PRIM2 | DNA replication |
| REAC:R-HSA-174411 | 1.83108883385e-05 | 0.5 | PRIM1 POLA2 PRIM2 | Polymerase switching on the C-strand of the telomere |
| GO:0005658 | 1.92180881975e-05 | 0.5 | PRIM1 POLA2 PRIM2 | alpha DNA polymerase:primase complex |
| GO:0006269 | 1.92180881975e-05 | 0.5 | PRIM1 POLA2 PRIM2 | DNA replication, synthesis of RNA primer |
| WP:WP466 | 3.14733202476e-05 | 0.5 | PRIM1 POLA2 PRIM2 | DNA replication |
| REAC:R-HSA-69190 | 3.48992434538e-05 | 0.5 | PRIM1 POLA2 PRIM2 | DNA strand elongation |
| REAC:R-HSA-68962 | 3.83832488858e-05 | 0.5 | PRIM1 POLA2 PRIM2 | Activation of the pre-replicative complex |
| REAC:R-HSA-174417 | 4.20912658431e-05 | 0.5 | PRIM1 POLA2 PRIM2 | Telomere C-strand (Lagging Strand) Synthesis |
| WP:WP45 | 0.000113837945426 | 0.5 | PRIM1 POLA2 PRIM2 | G1 to S cell cycle control |
| REAC:R-HSA-180786 | 0.000146098747122 | 0.5 | PRIM1 POLA2 PRIM2 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 0.000252100073401 | 0.5 | PRIM1 POLA2 PRIM2 | Defective pyroptosis |
| REAC:R-HSA-9645723 | 0.00084703415394 | 0.5 | PRIM1 POLA2 PRIM2 | Diseases of programmed cell death |
| REAC:R-HSA-157579 | 0.00112585873244 | 0.5 | PRIM1 POLA2 PRIM2 | Telomere Maintenance |
| REAC:R-HSA-69239 | 0.00190090644588 | 0.5 | PRIM1 POLA2 PRIM2 | Synthesis of DNA |
| GO:0042575 | 0.00218580514948 | 0.5 | PRIM1 POLA2 PRIM2 | DNA polymerase complex |
| REAC:R-HSA-73886 | 0.00231149151162 | 0.5 | PRIM1 POLA2 PRIM2 | Chromosome Maintenance |
| REAC:R-HSA-69206 | 0.00247941542207 | 0.5 | PRIM1 POLA2 PRIM2 | G1/S Transition |
| GO:0043601 | 0.00295184433846 | 0.5 | PRIM1 POLA2 PRIM2 | nuclear replisome |
| REAC:R-HSA-69002 | 0.00358509487789 | 0.5 | PRIM1 POLA2 PRIM2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.00358509487789 | 0.5 | PRIM1 POLA2 PRIM2 | Mitotic G1 phase and G1/S transition |
| GO:0030894 | 0.00387837112504 | 0.5 | PRIM1 POLA2 PRIM2 | replisome |
| REAC:R-HSA-69242 | 0.00453532495717 | 0.5 | PRIM1 POLA2 PRIM2 | S Phase |
| REAC:R-HSA-69306 | 0.0059397455674 | 0.5 | PRIM1 POLA2 PRIM2 | DNA Replication |
| GO:0006270 | 0.00949259421943 | 0.5 | PRIM1 POLA2 PRIM2 | DNA replication initiation |
| GO:0043596 | 0.017471616814 | 0.5 | PRIM1 POLA2 PRIM2 | nuclear replication fork |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRIM1 | POLA2 | 0.999 | 0.81 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| PRIM1 | PRIM2 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| BTF3 | NACA2 | 0.999 | bioplex3_HEK293 Guru bioplex3_WMM bioplex3_HCT116 fraction | |
| PRIM1 | NLGN4Y | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NLGN4Y | PRIM2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRIM1 | BTF3 | 0.988 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| PRIM2 | BTF3 | 0.966 | 0.246 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PRIM2 | POLA2 | 0.966 | 0.872 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PRIM1 | NACA2 | 0.82 | bioplex3_WMM WMM_only | |
| PRIM2 | NACA2 | 0.82 | bioplex3_WMM WMM_only | |
| POLA2 | BTF3 | 0.061 | 0.28 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| POLA2 | NACA2 | 0.041 | bioplex3_WMM fraction |
Related Complexes