hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11225.1

Complex Portal: CPX-14151

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
NAV2	Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)	5	UniProt NCBI
JADE1	Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17)	5	UniProt NCBI
PLCD4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4)	5	UniProt NCBI
KAT7	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	5	UniProt NCBI
ING4	Inhibitor of growth protein 4 (p29ING4)	5	UniProt NCBI
KAT6A	Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)	5	UniProt NCBI
JADE2	E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15)	5	UniProt NCBI
KAT6B	Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)	5	UniProt NCBI
ING5	Inhibitor of growth protein 5 (p28ING5)	5	UniProt NCBI
BRPF3	Bromodomain and PHD finger-containing protein 3	5	UniProt NCBI
JADE3	Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16)	5	UniProt NCBI
BRPF1	Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140)	5	UniProt NCBI
NAV3	Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)	5	UniProt NCBI
PDX1	Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0036408	2.18735073704e-16	0.5	KAT7 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	histone H3K14 acetyltransferase activity
REAC:R-HSA-3214847	5.49484053937e-16	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	HATs acetylate histones
GO:0000123	1.81380658017e-15	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	histone acetyltransferase complex
GO:0043997	2.00339021766e-15	0.5	KAT7 BRPF1 JADE1 JADE2 KAT6A BRPF3 ING4	histone H4K12 acetyltransferase activity
GO:0043996	2.00339021766e-15	0.5	KAT7 BRPF1 JADE1 JADE2 KAT6A BRPF3 ING4	histone H4K8 acetyltransferase activity
GO:0043995	2.00339021766e-15	0.5	KAT7 BRPF1 JADE1 JADE2 KAT6A BRPF3 ING4	histone H4K5 acetyltransferase activity
GO:1902493	5.61405475063e-15	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	acetyltransferase complex
GO:0031248	5.61405475063e-15	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	protein acetyltransferase complex
GO:0010484	2.0809054058e-14	0.5	KAT7 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	histone H3 acetyltransferase activity
GO:0004402	4.00902965004e-14	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	histone acetyltransferase activity
GO:0061733	6.7909644461e-14	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	peptide-lysine-N-acetyltransferase activity
GO:0034212	2.21493308188e-13	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	peptide N-acetyltransferase activity
GO:0070775	3.10642544305e-13	0.428571428571	BRPF1 KAT6B KAT7 ING5 KAT6A BRPF3	H3 histone acetyltransferase complex
GO:0010485	4.68840863499e-13	0.5	KAT7 BRPF1 JADE1 JADE2 KAT6A BRPF3 ING4	histone H4 acetyltransferase activity
REAC:R-HSA-3247509	4.74685939501e-13	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	Chromatin modifying enzymes
REAC:R-HSA-4839726	4.74685939501e-13	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	Chromatin organization
GO:0008080	2.54058318336e-12	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	N-acetyltransferase activity
GO:0016410	3.40704056349e-11	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	N-acyltransferase activity
GO:0016407	5.35955776349e-11	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	acetyltransferase activity
CORUM:7253	1.3739312217e-10	0.285714285714	KAT6B BRPF3 KAT6A ING5	ING5 (BRPF3, MOZ, MORF) complex
CORUM:2859	1.3739312217e-10	0.285714285714	BRPF1 KAT6B KAT6A ING5	ING5 (BRPF1, MOZ, MORF) complex
GO:0070776	3.78174024332e-10	0.357142857143	BRPF1 KAT6B BRPF3 KAT6A ING5	MOZ/MORF histone acetyltransferase complex
GO:0140993	2.85760651663e-08	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	histone modifying activity
GO:0016747	4.41888812341e-08	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	acyltransferase activity, transferring groups other than amino-acyl groups
CORUM:1352	1.4600392795e-07	0.214285714286	KAT7 JADE1 ING4	ING4 complex (ING4, JADE1, KAT7, MEAF6)
CORUM:2858	1.4600392795e-07	0.214285714286	KAT7 JADE1 ING5	ING5 complex (ING5, JADE1, KAT7, MEAF6)
CORUM:2847	1.4600392795e-07	0.214285714286	KAT7 ING4 JADE2	ING4 complex (ING4, JADE2, KAT7, MEAF6)
CORUM:2848	1.4600392795e-07	0.214285714286	KAT7 ING4 JADE3	ING4 complex (ING4, JADE3, KAT7, MEAF6)
CORUM:7255	1.4600392795e-07	0.214285714286	KAT7 JADE3 ING5	ING5 complex (ING5, JADE3, KAT7, MEAF6)
CORUM:7254	1.4600392795e-07	0.214285714286	KAT7 JADE2 ING5	ING5 complex (ING5, JADE2, KAT7, MEAF6)
CORUM:7252	3.64803730192e-07	0.214285714286	KAT6B KAT6A ING5	ING5 (BRPF2, MOZ, MORF) complex
GO:0000785	1.61271200552e-06	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	chromatin
GO:0032993	3.05737930146e-06	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	protein-DNA complex
REAC:R-HSA-6804758	3.99780189739e-06	0.285714285714	BRPF1 ING5 KAT6A BRPF3	Regulation of TP53 Activity through Acetylation
GO:1990234	7.02705485091e-06	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	transferase complex
GO:2000278	1.05134906418e-05	0.428571428571	KAT7 JADE3 JADE1 ING4 ING5 JADE2	regulation of DNA biosynthetic process
GO:0006275	1.11938723973e-05	0.428571428571	KAT7 JADE3 JADE1 JADE2 ING5 BRPF3	regulation of DNA replication
GO:0140535	1.23809498375e-05	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	intracellular protein-containing complex
GO:0140889	3.49876949518e-05	0.214285714286	KAT7 ING4 ING5	DNA replication-dependent chromatin disassembly
GO:0005694	8.1363701252e-05	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	chromosome
GO:0071897	0.000111176850687	0.428571428571	KAT7 JADE3 JADE1 ING4 ING5 JADE2	DNA biosynthetic process
GO:0016746	0.000541638304011	0.571428571429	KAT7 BRPF1 JADE1 ING4 KAT6B BRPF3 KAT6A JADE2	acyltransferase activity
GO:0006260	0.00128650127562	0.428571428571	KAT7 JADE3 JADE1 JADE2 ING5 BRPF3	DNA replication
GO:0051052	0.00207892056651	0.5	KAT7 JADE3 JADE1 JADE2 ING5 BRPF3 ING4	regulation of DNA metabolic process
REAC:R-HSA-5633007	0.00291591174888	0.285714285714	BRPF1 ING5 KAT6A BRPF3	Regulation of TP53 Activity
GO:0001558	0.00456507750748	0.428571428571	KAT7 JADE3 JADE1 ING4 ING5 JADE2	regulation of cell growth
GO:0006473	0.00500291608164	0.285714285714	KAT7 ING4 ING5 KAT6A	protein acetylation
GO:1902494	0.00511644805128	0.714285714286	KAT7 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	catalytic complex
GO:0016049	0.0100610676572	0.428571428571	KAT7 JADE3 JADE1 ING4 ING5 JADE2	cell growth
GO:0006355	0.0171988947556	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	regulation of DNA-templated transcription
GO:2001141	0.0183270923787	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	regulation of RNA biosynthetic process
GO:0040008	0.0184700974953	0.428571428571	KAT7 JADE3 JADE1 ING4 ING5 JADE2	regulation of growth
GO:0006351	0.0282778170099	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	DNA-templated transcription
GO:0032774	0.0316271774281	0.785714285714	KAT7 PDX1 ING5 JADE3 JADE1 ING4 KAT6B BRPF3 KAT6A BRPF1 JADE2	RNA biosynthetic process
GO:0043543	0.032484051154	0.285714285714	KAT7 ING4 ING5 KAT6A	protein acylation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
KAT7	JADE2	1.0	0.114
KAT7	BRPF3	1.0	0.418
ING5	KAT7	0.999	0.242
ING5	JADE2	0.999	0.156	mutually_exclusive (Q9HAF1) structurally_consistent (dimer)
JADE1	KAT7	0.999	0.132
KAT7	JADE3	0.999	0.302
ING5	BRPF3	0.999	0.394
ING5	NAV3	0.998	0.104
ING5	KAT6A	0.998	0.266
BRPF1	ING5	0.998	0.376
ING5	JADE1	0.997	0.212	structurally_consistent (dimer)
ING5	JADE3	0.997	0.176	structurally_consistent (dimer)
ING5	KAT6B	0.997	0.082
ING4	JADE2	0.995	0.092	structurally_consistent (dimer)
JADE2	JADE3	0.994	0.148
JADE1	ING4	0.994	0.266
ING4	JADE3	0.986	0.204
JADE1	JADE2	0.983	0.2
NAV3	PDX1	0.981
ING4	KAT7	0.98	0.07
ING5	ING4	0.976	0.152
JADE1	JADE3	0.956	0.156
NAV2	NAV3	0.952	0.114
ING5	NAV2	0.933	0.08
BRPF3	JADE3	0.926	0.216
JADE1	BRPF3	0.926	0.232
KAT6B	BRPF3	0.902	0.184
KAT6A	NAV3	0.902	0.066
KAT6B	NAV3	0.902	0.122
JADE1	NAV3	0.902	0.076
BRPF3	NAV3	0.902	0.092
JADE3	NAV3	0.902	0.062
JADE2	NAV3	0.902	0.068
BRPF1	PLCD4	0.871
BRPF1	NAV3	0.869	0.122
JADE2	BRPF3	0.86	0.154
KAT6B	KAT7	0.847	0.11
BRPF1	ING4	0.815	0.186
KAT6B	JADE2	0.81	0.154
BRPF1	BRPF3	0.79	0.392
KAT6A	JADE2	0.786	0.128
KAT6A	JADE1	0.786	0.302
KAT6B	JADE3	0.786	0.148
KAT6B	JADE1	0.786	0.102
BRPF1	JADE3	0.766	0.128
KAT6A	KAT6B	0.763	0.162
BRPF1	KAT6B	0.749	0.24
BRPF1	JADE2	0.747	0.208
BRPF1	KAT6A	0.719	0.218
KAT6A	JADE3	0.696	0.174
ING4	BRPF3	0.683	0.138
BRPF1	KAT7	0.667	0.316
KAT6A	BRPF3	0.608	0.208666666667
BRPF1	JADE1	0.603	0.17
KAT7	NAV3	0.455	0.072
KAT6B	ING4	0.432	0.148
KAT6B	NAV2	0.415	0.136
NAV2	PDX1	0.415
KAT6A	KAT7	0.401	0.134
KAT6A	ING4	0.333	0.266
KAT6A	NAV2	0.274	0.104
JADE1	NAV2	0.274	0.082
BRPF3	NAV2	0.274	0.144
JADE3	NAV2	0.274	0.088
JADE2	NAV2	0.274	0.078
BRPF1	NAV2	0.095	0.104
KAT7	NAV2	0.078	0.11

Related Complexes

Genename	Complexes
NAV2	huMAP3_03949.1 huMAP3_04756.1 huMAP3_06033.1 huMAP3_11225.1 huMAP3_13335.1
JADE1	huMAP3_03602.1 huMAP3_08842.1 huMAP3_11225.1 huMAP3_14438.1
PLCD4	huMAP3_11225.1 huMAP3_11318.1 huMAP3_11689.1 huMAP3_12789.1 huMAP3_13218.1 huMAP3_13581.1 huMAP3_14061.1
KAT7	huMAP3_03602.1 huMAP3_08842.1 huMAP3_11225.1
ING4	huMAP3_03602.1 huMAP3_08842.1 huMAP3_11225.1 huMAP3_14438.1
KAT6A	huMAP3_02713.1 huMAP3_03602.1 huMAP3_07188.1 huMAP3_08842.1 huMAP3_11225.1 huMAP3_14270.1 huMAP3_14389.1 huMAP3_14559.1
JADE2	huMAP3_03602.1 huMAP3_08842.1 huMAP3_11225.1
KAT6B	huMAP3_03596.1 huMAP3_03602.1 huMAP3_05205.1 huMAP3_07188.1 huMAP3_08918.1 huMAP3_11225.1 huMAP3_14306.1
ING5	huMAP3_02713.1 huMAP3_03602.1 huMAP3_07188.1 huMAP3_08842.1 huMAP3_11225.1 huMAP3_14306.1
BRPF3	huMAP3_03602.1 huMAP3_08842.1 huMAP3_11225.1 huMAP3_14306.1
JADE3	huMAP3_03602.1 huMAP3_08842.1 huMAP3_11225.1
BRPF1	huMAP3_01445.1 huMAP3_02713.1 huMAP3_03602.1 huMAP3_03799.1 huMAP3_07286.1 huMAP3_08142.1 huMAP3_08842.1 huMAP3_09447.1 huMAP3_10819.1 huMAP3_11225.1 huMAP3_11318.1 huMAP3_11969.1 huMAP3_14061.1 huMAP3_14265.1
NAV3	huMAP3_03949.1 huMAP3_11225.1 huMAP3_14679.1
PDX1	huMAP3_03949.1 huMAP3_11225.1 huMAP3_14679.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11225.1

Complex Portal: CPX-14151