hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11227.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF144A | E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4) | 5 | UniProt NCBI |
| VSTM2A | V-set and transmembrane domain-containing protein 2A | 5 | UniProt NCBI |
| NAE1 | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) | 5 | UniProt NCBI |
| UBA3 | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | 5 | UniProt NCBI |
| GTF2IRD2 | General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2162 | 1.36501667663e-05 | 0.4 | NAE1 UBA3 | APPBP1-UBA3 complex |
| WP:WP4860 | 0.00016455851106 | 0.4 | NAE1 UBA3 | Hijack of ubiquitination by SARS CoV 2 |
| GO:0019781 | 0.00468200720083 | 0.4 | NAE1 UBA3 | NEDD8 activating enzyme activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NAE1 | UBA3 | 0.982 | 0.98 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM |
| RNF144A | UBA3 | 0.971 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VSTM2A | UBA3 | 0.947 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VSTM2A | NAE1 | 0.929 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNF144A | NAE1 | 0.929 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GTF2IRD2 | UBA3 | 0.927 | 0.028 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes