hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11228.1
Complex Portal: CPX-23508
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LTBR | Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III) | 5 | UniProt NCBI |
| TCHP | Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein) | 5 | UniProt NCBI |
| CCDC121 | Coiled-coil domain-containing protein 121 | 2 | UniProt NCBI |
| TRAF3 | TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) | 5 | UniProt NCBI |
| PRC1 | Protein regulator of cytokinesis 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5676594 | 0.000835043279679 | 0.4 | LTBR TRAF3 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| KEGG:04064 | 0.0142114773497 | 0.4 | LTBR TRAF3 | NF-kappa B signaling pathway |
| CORUM:5530 | 0.0498708842806 | 0.2 | LTBR | LTBR homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CCDC121 | LTBR | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LTBR | TRAF3 | 0.994 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCHP | LTBR | 0.985 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PRC1 | LTBR | 0.97 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TCHP | CCDC121 | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PRC1 | CCDC121 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CCDC121 | TRAF3 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TCHP | TRAF3 | 0.127 | 0.116 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRC1 | TRAF3 | 0.118 | 0.094 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRC1 | TCHP | 0.062 | 0.07 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes