hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11237.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
SEC24C	Protein transport protein Sec24C (SEC24-related protein C)	5	UniProt NCBI
TRPC5	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)	5	UniProt NCBI
SEC23A	Protein transport protein Sec23A (hSec23A) (SEC23-related protein A)	5	UniProt NCBI
PRRC1	Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1)	5	UniProt NCBI
SEC24B	Protein transport protein Sec24B (SEC24-related protein B)	5	UniProt NCBI
SEC23B	Protein transport protein Sec23B (hSec23B) (SEC23-related protein B)	5	UniProt NCBI
SEC24A	Protein transport protein Sec24A (SEC24-related protein A)	5	UniProt NCBI
KIAA1217	Sickle tail protein homolog	5	UniProt NCBI
SRA1	Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)	5	UniProt NCBI
HSCB	Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]	5	UniProt NCBI
SEC24D	Protein transport protein Sec24D (SEC24-related protein D)	5	UniProt NCBI
RUBCNL	Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0090110	2.72660305059e-11	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	COPII-coated vesicle cargo loading
GO:0030127	2.72660305059e-11	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	COPII vesicle coat
GO:0070971	7.81141062112e-10	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	endoplasmic reticulum exit site
WP:WP1982	8.54902861772e-10	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	Sterol regulatory element binding proteins SREBP signaling
GO:0035459	2.49370856712e-09	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	vesicle cargo loading
REAC:R-HSA-5694530	3.10155279603e-09	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Cargo concentration in the ER
REAC:R-HSA-983170	3.10155279603e-09	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
GO:0090114	1.10190424824e-08	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	COPII-coated vesicle budding
GO:0012507	4.13138950064e-08	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	ER to Golgi transport vesicle membrane
KEGG:04141	6.11760717814e-08	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	Protein processing in endoplasmic reticulum
REAC:R-HSA-1655829	8.06548988254e-08	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Regulation of cholesterol biosynthesis by SREBP (SREBF)
GO:0030120	1.21782409259e-07	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	vesicle coat
REAC:R-HSA-204005	2.25471358868e-07	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	COPII-mediated vesicle transport
GO:0006900	5.21563271228e-07	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	vesicle budding from membrane
GO:0030134	5.68069683762e-07	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	COPII-coated ER to Golgi transport vesicle
GO:0048475	1.67683621086e-06	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	coated membrane
GO:0030117	1.67683621086e-06	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	membrane coat
REAC:R-HSA-9705671	4.9815011332e-06	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	SARS-CoV-2 activates/modulates innate and adaptive immune responses
REAC:R-HSA-2132295	6.20911383484e-06	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	MHC class II antigen presentation
REAC:R-HSA-8957322	7.66634197356e-06	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Metabolism of steroids
GO:0030658	9.25112785963e-06	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	transport vesicle membrane
GO:0006888	1.08224465784e-05	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	endoplasmic reticulum to Golgi vesicle-mediated transport
REAC:R-HSA-199977	1.70276620692e-05	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	ER to Golgi Anterograde Transport
GO:0016050	3.28884115366e-05	0.583333333333	SEC24C SEC24A SEC23A SEC24D RUBCNL SEC24B SEC23B	vesicle organization
CORUM:7139	3.75927585468e-05	0.166666666667	SEC23A SEC24B	SEC23-SEC24 adaptor complex
GO:0030662	4.1084642712e-05	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	coated vesicle membrane
REAC:R-HSA-948021	4.28817251365e-05	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Transport to the Golgi and subsequent modification
REAC:R-HSA-9705683	6.68046624941e-05	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	SARS-CoV-2-host interactions
GO:0061024	0.00010254561705	0.666666666667	SEC24C SEC24A SEC24B SEC24D SEC23A RUBCNL TRPC5 SEC23B	membrane organization
CORUM:7140	0.000225350794349	0.166666666667	SEC23A SEC24B	SEC23-SEC24-SCAP-SREBP1c complex
CORUM:7141	0.000375413311943	0.166666666667	SEC23A SEC24B	Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP)
KEGG:05130	0.000375564443522	0.333333333333	SEC24C SEC24D SEC24B SEC24A	Pathogenic Escherichia coli infection
REAC:R-HSA-9694516	0.000423859541085	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	SARS-CoV-2 Infection
GO:0030135	0.000505006032075	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	coated vesicle
REAC:R-HSA-446203	0.000506002100877	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Asparagine N-linked glycosylation
GO:0030133	0.00104905089538	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	transport vesicle
REAC:R-HSA-983169	0.00135623436332	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Class I MHC mediated antigen processing & presentation
GO:0048193	0.00158319444835	0.5	SEC24C SEC24A SEC23A SEC24D SEC24B SEC23B	Golgi vesicle transport
REAC:R-HSA-9679506	0.00203522320343	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	SARS-CoV Infections
TF:M11235_1	0.00347628273893	0.25	SEC24D SEC23A SEC24A	Factor: OASIS; motif: YGCCACGTCANC; match class: 1
REAC:R-HSA-199991	0.0155779267688	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Membrane Trafficking
REAC:R-HSA-5653656	0.0201934720737	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Vesicle-mediated transport
REAC:R-HSA-556833	0.021331654756	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Metabolism of lipids
HP:0002868	0.0231020257076	0.166666666667	SEC23A SEC24D	Narrow iliac wing
GO:0000149	0.0254514360933	0.333333333333	SEC24C SEC24D SEC24B SEC24A	SNARE binding
REAC:R-HSA-1280218	0.0314321021618	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Adaptive Immune System
REAC:R-HSA-9824446	0.0411802982613	0.416666666667	SEC24C SEC24A SEC24D SEC23A SEC24B	Viral Infection Pathways

Edges

Protein 1	Protein 2	Score	ProteomeHD
SEC23B	SEC24A	1.0	0.25
SEC23B	SEC24C	1.0	0.268
SEC23A	SEC24C	1.0	0.53
SEC23B	SEC23A	1.0	0.106
SEC23A	SEC24A	1.0	0.308
SEC23B	SEC24B	0.999	0.102
SEC23A	SEC24B	0.999	0.286666666667
SEC24B	SEC24A	0.996	0.156
SEC23B	SEC24D	0.993	0.208
SEC24C	SEC24B	0.992	0.27
SEC24C	SEC24A	0.991	0.386
SEC23A	SEC24D	0.981	0.302631578947
RUBCNL	SEC24A	0.978
HSCB	PRRC1	0.971	0.27156097561
SEC24B	TRPC5	0.969
SEC24D	SEC24A	0.963	0.266
SEC24C	PRRC1	0.955	0.174
PRRC1	SEC24A	0.954	0.132
SEC24D	PRRC1	0.938	0.216
SEC24B	PRRC1	0.935	0.066
SEC23B	SRA1	0.931	0.072
SEC23A	PRRC1	0.926	0.19
SEC23A	SRA1	0.923	0.052
TRPC5	SEC24A	0.922
SEC23B	RUBCNL	0.916
SEC24C	SRA1	0.915	0.1
SEC24D	SRA1	0.913	0.034
SEC23A	KIAA1217	0.91	0.072
RUBCNL	SEC24B	0.908
KIAA1217	SEC24A	0.841	0.092
KIAA1217	SEC24C	0.823	0.058
RUBCNL	SEC24C	0.728
SEC23B	PRRC1	0.682	0.108
SEC24D	SEC24C	0.602	0.136
KIAA1217	SEC24B	0.543	0.098
SEC23B	KIAA1217	0.443	0.104
SEC24A	SRA1	0.391	0.122
SEC23B	TRPC5	0.38
SEC24D	SEC24B	0.342	0.116
SEC23A	TRPC5	0.332
SEC24B	SRA1	0.327	0.04
SEC23A	RUBCNL	0.306
KIAA1217	SRA1	0.054	0.07
SEC24D	HSCB	0.016	0.3353735363
KIAA1217	HSCB	0.013	0.082
HSCB	SEC24A	0.012	0.29
SEC24D	KIAA1217	0.011	0.094
SEC23A	HSCB	0.009	0.132
SEC24C	HSCB	0.008	0.318
SEC23B	HSCB	0.006	0.308
KIAA1217	PRRC1	0.006	0.06
SEC24B	HSCB	0.005	0.264357142857

Related Complexes

Genename	Complexes
SEC24C	huMAP3_00707.1 huMAP3_06453.1 huMAP3_06773.1 huMAP3_07775.1 huMAP3_09282.1 huMAP3_11128.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_13535.1
TRPC5	huMAP3_03680.1 huMAP3_05704.1 huMAP3_09201.1 huMAP3_10615.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_13535.1 huMAP3_13878.1
SEC23A	huMAP3_00065.1 huMAP3_00707.1 huMAP3_06453.1 huMAP3_07775.1 huMAP3_09282.1 huMAP3_11128.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_13535.1
PRRC1	huMAP3_01462.1 huMAP3_08752.1 huMAP3_11237.1 huMAP3_11419.1 huMAP3_13535.1
SEC24B	huMAP3_01115.1 huMAP3_04806.1 huMAP3_06453.1 huMAP3_09201.1 huMAP3_10615.1 huMAP3_11128.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13535.1
SEC23B	huMAP3_00065.1 huMAP3_00707.1 huMAP3_06453.1 huMAP3_07775.1 huMAP3_09282.1 huMAP3_11128.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_13535.1
SEC24A	huMAP3_06453.1 huMAP3_09282.1 huMAP3_11128.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_13535.1
KIAA1217	huMAP3_00221.1 huMAP3_09553.1 huMAP3_11011.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_13535.1 huMAP3_14660.1
SRA1	huMAP3_11237.1 huMAP3_12394.1 huMAP3_12641.1 huMAP3_13535.1
HSCB	huMAP3_01462.1 huMAP3_08752.1 huMAP3_11237.1 huMAP3_11419.1 huMAP3_12346.1 huMAP3_13535.1
SEC24D	huMAP3_00065.1 huMAP3_00707.1 huMAP3_06453.1 huMAP3_07775.1 huMAP3_09282.1 huMAP3_11128.1 huMAP3_11237.1 huMAP3_12394.1 huMAP3_12641.1 huMAP3_13535.1
RUBCNL	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11237.1 huMAP3_11445.1 huMAP3_13535.1 huMAP3_14783.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11237.1