hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11238.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SYNGR3 | Synaptogyrin-3 | 5 | UniProt NCBI |
| MMEL1 | Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))] | 5 | UniProt NCBI |
| LMAN1 | Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) | 5 | UniProt NCBI |
| TMEM59 | Transmembrane protein 59 (Liver membrane-bound protein) | 5 | UniProt NCBI |
| MMP3 | Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) | 5 | UniProt NCBI |
| TIGD7 | Tigger transposable element-derived protein 7 | 3 | UniProt NCBI |
| NSG2 | Neuronal vesicle trafficking-associated protein 2 (Neuron-specific protein family member 2) (Protein p19) (Hmp19) | 5 | UniProt NCBI |
| MMP10 | Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP129 | 0.0045229597893 | 0.25 | MMP10 MMP3 | Matrix metalloproteinases |
| WP:WP5283 | 0.0125243956415 | 0.25 | MMP10 MMP3 | Chronic hyperglycemia impairment of neuron function |
| REAC:R-HSA-1592389 | 0.0153043597228 | 0.25 | MMP10 MMP3 | Activation of Matrix Metalloproteinases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MMP3 | MMP10 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MMP3 | MMEL1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MMP3 | TIGD7 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SYNGR3 | TMEM59 | 0.938 | 0.058 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| TMEM59 | MMP10 | 0.935 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LMAN1 | MMP3 | 0.932 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MMEL1 | MMP10 | 0.902 | bioplex3_WMM WMM_only | |
| TMEM59 | MMP3 | 0.863 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LMAN1 | MMP10 | 0.847 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NSG2 | TMEM59 | 0.823 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LMAN1 | TMEM59 | 0.82 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| LMAN1 | NSG2 | 0.047 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| LMAN1 | MMEL1 | 0.03 | bioplex3_WMM WMM_only | |
| LMAN1 | SYNGR3 | 0.029 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| TMEM59 | MMEL1 | 0.026 | bioplex3_WMM WMM_only |
Related Complexes