hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11244.1
Complex Portal: CPX-20970
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3) | 5 | UniProt NCBI |
| FAHD1 | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (YisK-like protein) | 5 | UniProt NCBI |
| TRIT1 | tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) | 5 | UniProt NCBI |
| GUK1 | Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1) | 5 | UniProt NCBI |
| TRMT5 | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011923 | 0.00148214139581 | 0.6 | MT-ND3 TRMT5 TRIT1 | Decreased activity of mitochondrial complex I |
| HP:0008972 | 0.00443745887352 | 0.6 | MT-ND3 TRMT5 TRIT1 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.00486809738821 | 0.6 | MT-ND3 TRMT5 TRIT1 | Abnormal activity of mitochondrial respiratory chain |
| REAC:R-HSA-6782315 | 0.0100756681589 | 0.4 | TRIT1 TRMT5 | tRNA modification in the nucleus and cytosol |
| HP:0003287 | 0.0113572466436 | 0.6 | MT-ND3 TRMT5 TRIT1 | Abnormality of mitochondrial metabolism |
| KEGG:01100 | 0.0139298332568 | 0.8 | MT-ND3 GUK1 FAHD1 TRIT1 | Metabolic pathways |
| HP:0012103 | 0.0166933934022 | 0.6 | MT-ND3 TRMT5 TRIT1 | Abnormality of the mitochondrion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FAHD1 | GUK1 | 0.977 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAHD1 | TRMT5 | 0.975 | 0.034 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAHD1 | TRIT1 | 0.944 | 0.078 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MT-ND3 | TRIT1 | 0.902 | 0.148 | bioplex3_WMM WMM_only | |
| TRMT5 | TRIT1 | 0.801 | 0.1 | bioplex3_WMM youn_WMM WMM_only | |
| GUK1 | TRIT1 | 0.715 | 0.056 | bioplex3_WMM WMM_only | |
| GUK1 | TRMT5 | 0.715 | 0.014 | bioplex3_WMM WMM_only | |
| MT-ND3 | FAHD1 | 0.042 | 0.564 | bioplex3_WMM WMM_only |
Related Complexes