hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11257.1

Complex Portal: CPX-16629

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RCAN1	Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)	5	UniProt NCBI
AXIN2	Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)	5	UniProt NCBI
GSKIP	GSK3B-interacting protein (GSKIP) (GSK3beta interaction protein)	5	UniProt NCBI
GSK3A	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)	5	UniProt NCBI
FRAT2	GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)	3	UniProt NCBI
GSK3B	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	5	UniProt NCBI
FRAT1	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1)	5	UniProt NCBI
RILPL2	RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein)	5	UniProt NCBI
CATSPER2	Cation channel sperm-associated protein 2 (CatSper2)	5	UniProt NCBI
AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-196299	6.32607926503e-08	0.4	FRAT2 AXIN1 FRAT1 GSK3B	Beta-catenin phosphorylation cascade
WP:WP4258	1.26830251876e-07	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	lncRNA in canonical Wnt signaling and colorectal cancer
KEGG:05224	5.61017394541e-07	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Breast cancer
GO:0060070	5.98064921821e-07	0.7	FRAT2 AXIN2 FRAT1 AXIN1 GSKIP GSK3B GSK3A	canonical Wnt signaling pathway
KEGG:05226	6.55971078187e-07	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Gastric cancer
REAC:R-HSA-4641262	8.32503276128e-07	0.4	FRAT2 AXIN1 FRAT1 GSK3B	Disassembly of the destruction complex and recruitment of AXIN to the membrane
KEGG:04310	1.29689944557e-06	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Wnt signaling pathway
WP:WP4262	1.38398941122e-06	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Breast cancer pathway
WP:WP363	1.59895364063e-06	0.4	GSK3A AXIN1 FRAT1 GSK3B	Wnt signaling pathway
KEGG:05225	1.73773564836e-06	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Hepatocellular carcinoma
GO:0030877	1.81927560642e-06	0.4	AXIN2 AXIN1 GSK3B GSK3A	beta-catenin destruction complex
GO:0016055	5.54953663704e-06	0.7	FRAT2 AXIN2 FRAT1 AXIN1 GSKIP GSK3B GSK3A	Wnt signaling pathway
GO:0198738	6.1222538852e-06	0.7	FRAT2 AXIN2 FRAT1 AXIN1 GSKIP GSK3B GSK3A	cell-cell signaling by wnt
WP:WP4872	8.23219900182e-06	0.3	GSK3B FRAT1 AXIN1	MAP3K1 role in promoting and blocking gonadal determination
WP:WP4336	1.22306700697e-05	0.4	FRAT2 AXIN1 FRAT1 GSK3B	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
GO:0060828	1.98346738234e-05	0.6	AXIN2 FRAT1 AXIN1 GSKIP GSK3B GSK3A	regulation of canonical Wnt signaling pathway
WP:WP5124	2.19679744334e-05	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Alzheimer 39 s disease
WP:WP2059	2.19679744334e-05	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Alzheimer 39 s disease and miRNA effects
CORUM:7128	3.07577115383e-05	0.2	GSK3B GSKIP	GSKIP-GSK3B-PRKAR2A complex
CORUM:7127	3.07577115383e-05	0.2	GSK3B GSKIP	GSKIP-GSK3B-PRKAR2A complex
REAC:R-HSA-201681	3.12083180803e-05	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	TCF dependent signaling in response to WNT
WP:WP399	3.22018663705e-05	0.4	AXIN2 AXIN1 FRAT1 GSK3B	Wnt signaling pathway and pluripotency
WP:WP428	4.30150812668e-05	0.4	FRAT2 AXIN1 FRAT1 GSK3B	Wnt signaling
REAC:R-HSA-195253	4.33004932357e-05	0.4	FRAT2 AXIN1 FRAT1 GSK3B	Degradation of beta-catenin by the destruction complex
GO:1904886	4.61210427592e-05	0.3	FRAT2 FRAT1 GSK3B	beta-catenin destruction complex disassembly
KEGG:05010	7.62846862374e-05	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Alzheimer disease
CORUM:6352	9.22394575203e-05	0.2	GSK3B AXIN1	FoxM1-Axin-GSK3beta complex
CORUM:6353	9.22394575203e-05	0.2	GSK3B AXIN1	beta-Catenin destruction complex
CORUM:6963	9.22394575203e-05	0.2	GSK3B AXIN1	AXIN1-GID8-GSK3B complex
CORUM:7130	9.22394575203e-05	0.2	GSK3B GSKIP	PRKAR2A-GSKIP-GSK3B-DNM1L complex
CORUM:3166	9.22394575203e-05	0.2	GSK3B AXIN1	AXIN1-APC-CTNNB1-GSK3B complex
GO:0030111	0.00011153855885	0.6	AXIN2 FRAT1 AXIN1 GSKIP GSK3B GSK3A	regulation of Wnt signaling pathway
CORUM:7159	0.000184411585051	0.2	GSK3B AXIN1	TSC2-GSK3-AXIN-DVL complex
CORUM:4151	0.000184411585051	0.2	GSK3B AXIN1	TSC (TSC1, TSC2, AXIN, GSK3) complex
CORUM:2998	0.000184411585051	0.2	GSK3B AXIN1	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex
REAC:R-HSA-195721	0.000187650116668	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Signaling by WNT
KEGG:05022	0.000200911474306	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Pathways of neurodegeneration - multiple diseases
KEGG:05213	0.00025222334173	0.3	AXIN2 AXIN1 GSK3B	Endometrial cancer
KEGG:05200	0.000289324227938	0.5	AXIN2 AXIN1 GSK3B FRAT1 FRAT2	Pathways in cancer
KEGG:05217	0.00029909224236	0.3	AXIN2 AXIN1 GSK3B	Basal cell carcinoma
WP:WP4155	0.00065158533309	0.3	AXIN2 AXIN1 GSK3B	Endometrial cancer
KEGG:05210	0.000860152101115	0.3	AXIN2 AXIN1 GSK3B	Colorectal cancer
WP:WP4216	0.00106295369076	0.3	AXIN2 AXIN1 GSK3B	Chromosomal and microsatellite instability in colorectal cancer
WP:WP2064	0.00143474462389	0.3	AXIN2 AXIN1 GSK3B	Neural crest differentiation
KEGG:04550	0.00312760944256	0.3	AXIN2 AXIN1 GSK3B	Signaling pathways regulating pluripotency of stem cells
KEGG:04934	0.00353228654663	0.3	AXIN2 AXIN1 GSK3B	Cushing syndrome
WP:WP710	0.00365274550904	0.3	GSK3B FRAT1 AXIN1	DNA damage response only ATM dependent
REAC:R-HSA-9683610	0.0036548283771	0.2	GSK3A GSK3B	Maturation of nucleoprotein
WP:WP3664	0.0049515659161	0.2	GSK3B AXIN1	Regulation of Wnt B catenin signaling by small molecule compounds
GO:0032436	0.00495760415907	0.4	AXIN2 AXIN1 GSK3B GSK3A	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
KEGG:04390	0.00560546698078	0.3	AXIN2 AXIN1 GSK3B	Hippo signaling pathway
WP:WP3872	0.00704825789595	0.2	GSK3A GSK3B	Regulation of apoptosis by parathyroid hormone related protein
WP:WP5087	0.0075599887011	0.4	FRAT2 AXIN1 FRAT1 GSK3B	Pleural mesothelioma
REAC:R-HSA-9694631	0.00790724004214	0.2	GSK3A GSK3B	Maturation of nucleoprotein
REAC:R-HSA-198323	0.00790724004214	0.2	GSK3A GSK3B	AKT phosphorylates targets in the cytosol
REAC:R-HSA-4839744	0.00922174626729	0.2	GSK3B AXIN1	Signaling by APC mutants
REAC:R-HSA-4839748	0.00922174626729	0.2	GSK3B AXIN1	Signaling by AMER1 mutants
REAC:R-HSA-5467348	0.00922174626729	0.2	GSK3B AXIN1	Truncations of AMER1 destabilize the destruction complex
REAC:R-HSA-4839735	0.00922174626729	0.2	GSK3B AXIN1	Signaling by AXIN mutants
REAC:R-HSA-5467340	0.00922174626729	0.2	GSK3B AXIN1	AXIN missense mutants destabilize the destruction complex
REAC:R-HSA-5467337	0.00922174626729	0.2	GSK3B AXIN1	APC truncation mutants have impaired AXIN binding
WP:WP2583	0.00951090854291	0.2	GSK3A GSK3B	T cell receptor and co stimulatory signaling
GO:2000060	0.0103846818546	0.4	AXIN2 AXIN1 GSK3B GSK3A	positive regulation of ubiquitin-dependent protein catabolic process
REAC:R-HSA-4839743	0.0106365927257	0.2	GSK3B AXIN1	Signaling by CTNNB1 phospho-site mutants
REAC:R-HSA-5358747	0.0106365927257	0.2	GSK3B AXIN1	CTNNB1 S33 mutants aren't phosphorylated
REAC:R-HSA-5358749	0.0106365927257	0.2	GSK3B AXIN1	CTNNB1 S37 mutants aren't phosphorylated
REAC:R-HSA-5358751	0.0106365927257	0.2	GSK3B AXIN1	CTNNB1 S45 mutants aren't phosphorylated
REAC:R-HSA-5358752	0.0106365927257	0.2	GSK3B AXIN1	CTNNB1 T41 mutants aren't phosphorylated
REAC:R-HSA-5339716	0.0106365927257	0.2	GSK3B AXIN1	Signaling by GSK3beta mutants
WP:WP3658	0.0113553886492	0.2	AXIN2 GSK3B	Wnt beta catenin signaling pathway in leukemia
GO:1901800	0.0137249930817	0.4	AXIN2 AXIN1 GSK3B GSK3A	positive regulation of proteasomal protein catabolic process
GO:0090090	0.0149986773182	0.4	AXIN2 AXIN1 GSK3B GSK3A	negative regulation of canonical Wnt signaling pathway
GO:0046825	0.0176420810956	0.3	FRAT2 FRAT1 GSK3B	regulation of protein export from nucleus
WP:WP4844	0.0178579187559	0.2	GSK3B AXIN1	Influence of laminopathies on Wnt signaling
WP:WP127	0.0190825311458	0.2	GSK3A GSK3B	IL 5 signaling pathway
GO:2000077	0.0210690324038	0.2	GSK3A GSK3B	negative regulation of type B pancreatic cell development
GO:0007267	0.0220289791766	0.7	FRAT2 AXIN2 FRAT1 AXIN1 GSKIP GSK3B GSK3A	cell-cell signaling
GO:1903052	0.0255498654968	0.4	AXIN2 AXIN1 GSK3B GSK3A	positive regulation of proteolysis involved in protein catabolic process
WP:WP500	0.0272713027679	0.2	GSK3A GSK3B	Glycogen synthesis and degradation
GO:0032434	0.028615496869	0.4	AXIN2 AXIN1 GSK3B GSK3A	regulation of proteasomal ubiquitin-dependent protein catabolic process
REAC:R-HSA-5674400	0.0302795201711	0.2	GSK3A GSK3B	Constitutive Signaling by AKT1 E17K in Cancer
REAC:R-HSA-9683701	0.032790839879	0.2	GSK3A GSK3B	Translation of Structural Proteins
GO:0030178	0.0368293644996	0.4	AXIN2 AXIN1 GSK3B GSK3A	negative regulation of Wnt signaling pathway
KEGG:05165	0.0438405134702	0.3	AXIN2 AXIN1 GSK3B	Human papillomavirus infection
WP:WP4879	0.0441033585523	0.2	GSK3B AXIN1	Overlap between signal transduction pathways contributing to LMNA laminopathies

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
GSK3A	GSK3B	1.0	0.196		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction
GSK3A	RCAN1	0.999	0.184		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSK3A	FRAT1	0.999		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
FRAT2	RILPL2	0.999			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSKIP	GSK3A	0.999	0.09	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3A	AXIN1	0.998	0.23		hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
GSK3A	FRAT2	0.997		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSKIP	GSK3B	0.997	0.136		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AXIN2	GSK3A	0.997			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3B	FRAT2	0.996			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3B	RCAN1	0.996	0.088		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSK3B	AXIN1	0.995	0.256		hein_WMM bioplex3_WMM hein () gupta_WMM
AXIN2	GSK3B	0.992			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3B	FRAT1	0.992			hein_WMM bioplex3_WMM hein ()
FRAT1	AXIN1	0.946			bioplex3_WMM WMM_only
AXIN2	FRAT1	0.946			bioplex3_WMM WMM_only
AXIN2	AXIN1	0.946			bioplex3_WMM WMM_only
RCAN1	CATSPER2	0.928			bioplex3_HEK293 bioplex3_WMM WMM_only
FRAT1	RCAN1	0.905			bioplex3_WMM WMM_only
GSK3A	RILPL2	0.874	0.106		bioplex3_WMM WMM_only
GSKIP	FRAT1	0.792		mutually_exclusive (P49840)	bioplex3_WMM WMM_only
GSKIP	AXIN1	0.757	0.212		bioplex3_WMM WMM_only
AXIN1	RCAN1	0.757	0.267333333333		bioplex3_WMM WMM_only
GSK3B	RILPL2	0.74	0.038		bioplex3_WMM WMM_only
AXIN2	RCAN1	0.49			bioplex3_WMM WMM_only
GSKIP	RCAN1	0.467	0.134		bioplex3_WMM WMM_only
AXIN2	GSKIP	0.466			bioplex3_WMM WMM_only
AXIN2	FRAT2	0.274			bioplex3_WMM WMM_only
AXIN1	FRAT2	0.25			bioplex3_WMM WMM_only
FRAT1	FRAT2	0.135		mutually_exclusive (P49840)	bioplex3_WMM WMM_only
FRAT2	RCAN1	0.078			bioplex3_WMM WMM_only
GSKIP	FRAT2	0.078		mutually_exclusive (P49840)	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RCAN1	huMAP3_04454.1 huMAP3_06005.1 huMAP3_07944.1 huMAP3_10807.1 huMAP3_11257.1 huMAP3_15008.1
AXIN2	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1
GSKIP	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1 huMAP3_13368.1 huMAP3_14060.1
GSK3A	huMAP3_00673.1 huMAP3_04454.1 huMAP3_06005.1 huMAP3_07944.1 huMAP3_10801.1 huMAP3_10807.1 huMAP3_11257.1
FRAT2	huMAP3_01861.1 huMAP3_02919.1 huMAP3_09537.1 huMAP3_10801.1 huMAP3_11257.1
GSK3B	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1
FRAT1	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1
RILPL2	huMAP3_02919.1 huMAP3_09537.1 huMAP3_10801.1 huMAP3_11257.1
CATSPER2	huMAP3_11257.1
AXIN1	huMAP3_00673.1 huMAP3_01565.1 huMAP3_09115.1 huMAP3_10801.1 huMAP3_11257.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11257.1

Complex Portal: CPX-16629