hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11272.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD50 | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | 5 | UniProt NCBI |
| CFAP161 | Cilia- and flagella-associated protein 161 | 4 | UniProt NCBI |
| MRE11 | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | 5 | UniProt NCBI |
| NBN | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:618 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:73 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:972 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:173 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:1081 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:2767 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | RAD50-MRE11-NBN-p200-p350 complex |
| CORUM:331 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:71 | 7.01606139244e-10 | 0.75 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:619 | 2.80628050973e-09 | 0.75 | RAD50 NBN MRE11 | MRE11A-RAD50-NBN-TRF2 complex |
| CORUM:2218 | 2.80628050973e-09 | 0.75 | RAD50 NBN MRE11 | MDC1-MRE11-RAD50-NBS1 complex |
| CORUM:627 | 2.80628050973e-09 | 0.75 | RAD50 NBN MRE11 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) |
| CORUM:202 | 2.80628050973e-09 | 0.75 | RAD50 NBN MRE11 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:964 | 2.80628050973e-09 | 0.75 | RAD50 NBN MRE11 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:1189 | 7.01534115619e-09 | 0.75 | RAD50 NBN MRE11 | DNA double-strand break end-joining complex |
| WP:WP2942 | 1.22309481131e-08 | 0.75 | RAD50 NBN MRE11 | DDX1 as a regulatory component of the Drosha microprocessor |
| CORUM:5197 | 1.40299620761e-08 | 0.75 | RAD50 NBN MRE11 | PTIP-DNA damage response complex |
| CORUM:2217 | 1.40299620761e-08 | 0.75 | RAD50 NBN MRE11 | MDC1-MRN-ATM-FANCD2 complex |
| REAC:R-HSA-5693548 | 2.80599241523e-08 | 0.75 | RAD50 NBN MRE11 | Sensing of DNA Double Strand Breaks |
| CORUM:2815 | 3.92798604902e-08 | 0.75 | RAD50 NBN MRE11 | BRCA1-BARD1-BACH1-DNA damage complex II |
| WP:WP5118 | 5.7648343278e-08 | 0.75 | RAD50 NBN MRE11 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome |
| WP:WP186 | 7.68605108093e-08 | 0.75 | RAD50 NBN MRE11 | Homologous recombination |
| CORUM:433 | 1.54282047245e-07 | 0.75 | RAD50 NBN MRE11 | BASC complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-5685939 | 2.31434954766e-07 | 0.75 | RAD50 NBN MRE11 | HDR through MMEJ (alt-NHEJ) |
| GO:0031860 | 1.53784171933e-06 | 0.75 | RAD50 NBN MRE11 | telomeric 3' overhang formation |
| HP:0030406 | 1.66514003543e-06 | 0.75 | RAD50 NBN MRE11 | Primary peritoneal carcinoma |
| REAC:R-HSA-9709603 | 2.8370403595e-06 | 0.75 | RAD50 NBN MRE11 | Impaired BRCA2 binding to PALB2 |
| WP:WP2516 | 2.94331624137e-06 | 0.75 | RAD50 NBN MRE11 | ATM signaling pathway |
| REAC:R-HSA-9701193 | 3.2237438451e-06 | 0.75 | RAD50 NBN MRE11 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9701192 | 3.2237438451e-06 | 0.75 | RAD50 NBN MRE11 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9704646 | 3.2237438451e-06 | 0.75 | RAD50 NBN MRE11 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9704331 | 3.2237438451e-06 | 0.75 | RAD50 NBN MRE11 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| KEGG:03440 | 3.38522311544e-06 | 0.75 | RAD50 NBN MRE11 | Homologous recombination |
| WP:WP3878 | 3.71869501007e-06 | 0.75 | RAD50 NBN MRE11 | ATM signaling in development and disease |
| GO:0030870 | 3.84440695359e-06 | 0.75 | RAD50 NBN MRE11 | Mre11 complex |
| REAC:R-HSA-5693554 | 4.0993398561e-06 | 0.75 | RAD50 NBN MRE11 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| CORUM:263 | 5.12628525639e-06 | 0.5 | RAD50 MRE11 | R/M complex (RAD50-MRE11 complex) |
| CORUM:264 | 5.12628525639e-06 | 0.5 | RAD50 MRE11 | R/M complex (RAD50-MRE11 complex) |
| CORUM:72 | 5.12628525639e-06 | 0.5 | RAD50 MRE11 | R/M complex (RAD50-MRE11 complex) |
| REAC:R-HSA-5693568 | 7.64413736449e-06 | 0.75 | RAD50 NBN MRE11 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| GO:0070533 | 7.68841921772e-06 | 0.75 | RAD50 NBN MRE11 | BRCA1-C complex |
| WP:WP3959 | 7.70512833643e-06 | 0.75 | RAD50 NBN MRE11 | DNA IR double strand breaks and cellular response via ATM |
| REAC:R-HSA-5693537 | 8.38346160394e-06 | 0.75 | RAD50 NBN MRE11 | Resolution of D-Loop Structures |
| REAC:R-HSA-9709570 | 8.38346160394e-06 | 0.75 | RAD50 NBN MRE11 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 9.16893973468e-06 | 0.75 | RAD50 NBN MRE11 | HDR through Single Strand Annealing (SSA) |
| HP:0011027 | 1.18865274487e-05 | 0.75 | RAD50 NBN MRE11 | Abnormal fallopian tube morphology |
| REAC:R-HSA-5693616 | 1.28002609524e-05 | 0.75 | RAD50 NBN MRE11 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 1.38374083551e-05 | 0.75 | RAD50 NBN MRE11 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 1.38374083551e-05 | 0.75 | RAD50 NBN MRE11 | Diseases of DNA Double-Strand Break Repair |
| WP:WP1530 | 1.52187722416e-05 | 0.75 | RAD50 NBN MRE11 | miRNA regulation of DNA damage response |
| WP:WP707 | 1.52187722416e-05 | 0.75 | RAD50 NBN MRE11 | DNA damage response |
| REAC:R-HSA-5693579 | 1.60766305396e-05 | 0.75 | RAD50 NBN MRE11 | Homologous DNA Pairing and Strand Exchange |
| GO:0110025 | 2.15253635486e-05 | 0.75 | RAD50 NBN MRE11 | DNA strand resection involved in replication fork processing |
| HP:0012125 | 2.49344480699e-05 | 0.75 | RAD50 NBN MRE11 | Prostate cancer |
| HP:0100787 | 2.49344480699e-05 | 0.75 | RAD50 NBN MRE11 | Prostate neoplasm |
| WP:WP4016 | 2.54708175834e-05 | 0.75 | RAD50 NBN MRE11 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-9675135 | 2.57917427086e-05 | 0.75 | RAD50 NBN MRE11 | Diseases of DNA repair |
| HP:0008775 | 4.17532321542e-05 | 0.75 | RAD50 NBN MRE11 | Abnormal prostate morphology |
| REAC:R-HSA-5693571 | 5.03512663474e-05 | 0.75 | RAD50 NBN MRE11 | Nonhomologous End-Joining (NHEJ) |
| CORUM:2766 | 5.12488211613e-05 | 0.5 | RAD50 MRE11 | TERF2-RAP1 complex |
| CORUM:1193 | 5.12488211613e-05 | 0.5 | RAD50 MRE11 | Rap1 complex |
| REAC:R-HSA-5685942 | 6.40033583955e-05 | 0.75 | RAD50 NBN MRE11 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-2559586 | 6.70000655285e-05 | 0.75 | RAD50 NBN MRE11 | DNA Damage/Telomere Stress Induced Senescence |
| HP:0033019 | 7.89834426977e-05 | 0.75 | RAD50 NBN MRE11 | Male reproductive system neoplasm |
| REAC:R-HSA-5693565 | 7.99206750774e-05 | 0.75 | RAD50 NBN MRE11 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| WP:WP4946 | 8.13748974369e-05 | 0.75 | RAD50 NBN MRE11 | DNA repair pathways full network |
| REAC:R-HSA-5693606 | 8.33911915483e-05 | 0.75 | RAD50 NBN MRE11 | DNA Double Strand Break Response |
| REAC:R-HSA-912446 | 8.33911915483e-05 | 0.75 | RAD50 NBN MRE11 | Meiotic recombination |
| WP:WP4262 | 0.000133081990362 | 0.75 | RAD50 NBN MRE11 | Breast cancer pathway |
| KEGG:03450 | 0.000137838736806 | 0.5 | RAD50 MRE11 | Non-homologous end-joining |
| REAC:R-HSA-69473 | 0.000148092217351 | 0.75 | RAD50 NBN MRE11 | G2/M DNA damage checkpoint |
| KEGG:04218 | 0.000152567450385 | 0.75 | RAD50 NBN MRE11 | Cellular senescence |
| REAC:R-HSA-6804756 | 0.000158650980172 | 0.75 | RAD50 NBN MRE11 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.000164113242291 | 0.75 | RAD50 NBN MRE11 | Processing of DNA double-strand break ends |
| HP:0000022 | 0.000181203229342 | 0.75 | RAD50 NBN MRE11 | Abnormal male internal genitalia morphology |
| HP:0100615 | 0.000199293446021 | 0.75 | RAD50 NBN MRE11 | Ovarian neoplasm |
| GO:0000729 | 0.000215165225046 | 0.75 | RAD50 NBN MRE11 | DNA double-strand break processing |
| HP:0003002 | 0.000218547832795 | 0.75 | RAD50 NBN MRE11 | Breast carcinoma |
| REAC:R-HSA-1500620 | 0.000219007946647 | 0.75 | RAD50 NBN MRE11 | Meiosis |
| HP:0002861 | 0.000228622881885 | 0.75 | RAD50 NBN MRE11 | Melanoma |
| REAC:R-HSA-1474165 | 0.00031803083943 | 0.75 | RAD50 NBN MRE11 | Reproduction |
| HP:0002894 | 0.000360544079166 | 0.75 | RAD50 NBN MRE11 | Neoplasm of the pancreas |
| REAC:R-HSA-5693567 | 0.000422025999557 | 0.75 | RAD50 NBN MRE11 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| GO:0031954 | 0.000437924933217 | 0.75 | RAD50 NBN MRE11 | positive regulation of protein autophosphorylation |
| HP:0010785 | 0.000466429417353 | 0.75 | RAD50 NBN MRE11 | Gonadal neoplasm |
| REAC:R-HSA-5693538 | 0.000487256563506 | 0.75 | RAD50 NBN MRE11 | Homology Directed Repair |
| HP:0100013 | 0.00050008620032 | 0.75 | RAD50 NBN MRE11 | Neoplasm of the breast |
| REAC:R-HSA-5633007 | 0.000799005459147 | 0.75 | RAD50 NBN MRE11 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.000897810107574 | 0.75 | RAD50 NBN MRE11 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.000915028341188 | 0.75 | RAD50 NBN MRE11 | G2/M Checkpoints |
| REAC:R-HSA-2559583 | 0.00122110889015 | 0.75 | RAD50 NBN MRE11 | Cellular Senescence |
| GO:0031952 | 0.00155882617412 | 0.75 | RAD50 NBN MRE11 | regulation of protein autophosphorylation |
| HP:0010787 | 0.00158938450477 | 0.75 | RAD50 NBN MRE11 | Genital neoplasm |
| WP:WP1971 | 0.00198508114189 | 0.5 | RAD50 MRE11 | Integrated cancer pathway |
| GO:0016233 | 0.0025122894873 | 0.75 | RAD50 NBN MRE11 | telomere capping |
| GO:0022616 | 0.00298219742351 | 0.75 | RAD50 NBN MRE11 | DNA strand elongation |
| REAC:R-HSA-69620 | 0.00495341247057 | 0.75 | RAD50 NBN MRE11 | Cell Cycle Checkpoints |
| GO:0031297 | 0.00544401218013 | 0.75 | RAD50 NBN MRE11 | replication fork processing |
| GO:0032508 | 0.00544401218013 | 0.75 | RAD50 NBN MRE11 | DNA duplex unwinding |
| GO:0044818 | 0.00582352741409 | 0.75 | RAD50 NBN MRE11 | mitotic G2/M transition checkpoint |
| HP:0000137 | 0.0058618765749 | 0.75 | RAD50 NBN MRE11 | Abnormality of the ovary |
| HP:0007379 | 0.0058618765749 | 0.75 | RAD50 NBN MRE11 | Neoplasm of the genitourinary tract |
| GO:0035825 | 0.00622026610693 | 0.75 | RAD50 NBN MRE11 | homologous recombination |
| WP:WP4656 | 0.0063063631888 | 0.5 | RAD50 MRE11 | Joubert syndrome |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | RAD50 NBN MRE11 | DNA Repair |
| GO:0045005 | 0.00847564117007 | 0.75 | RAD50 NBN MRE11 | DNA-templated DNA replication maintenance of fidelity |
| REAC:R-HSA-3700989 | 0.00879681508035 | 0.75 | RAD50 NBN MRE11 | Transcriptional Regulation by TP53 |
| GO:0032392 | 0.0089837173405 | 0.75 | RAD50 NBN MRE11 | DNA geometric change |
| GO:0010972 | 0.0100599149475 | 0.75 | RAD50 NBN MRE11 | negative regulation of G2/M transition of mitotic cell cycle |
| HPA:0301363 | 0.0101307410249 | 0.75 | RAD50 NBN MRE11 | lung; alveolar cells type I[High] |
| GO:1902750 | 0.0112187083505 | 0.75 | RAD50 NBN MRE11 | negative regulation of cell cycle G2/M phase transition |
| WP:WP2263 | 0.0113062844995 | 0.5 | RAD50 MRE11 | Androgen receptor network in prostate cancer |
| GO:0071103 | 0.0131184183431 | 0.75 | RAD50 NBN MRE11 | DNA conformation change |
| HP:0001732 | 0.014163057839 | 0.75 | RAD50 NBN MRE11 | Abnormality of the pancreas |
| HP:0034930 | 0.0144834290023 | 0.75 | RAD50 NBN MRE11 | Digestive system neoplasm |
| HP:0007378 | 0.0144834290023 | 0.75 | RAD50 NBN MRE11 | Neoplasm of the gastrointestinal tract |
| GO:0000019 | 0.0168521501606 | 0.5 | RAD50 MRE11 | regulation of mitotic recombination |
| GO:0032206 | 0.0183580179548 | 0.75 | RAD50 NBN MRE11 | positive regulation of telomere maintenance |
| HP:0011792 | 0.020281879533 | 0.75 | RAD50 NBN MRE11 | Neoplasm by histology |
| GO:0035861 | 0.0269276802074 | 0.75 | RAD50 NBN MRE11 | site of double-strand break |
| GO:0010389 | 0.0326725154884 | 0.75 | RAD50 NBN MRE11 | regulation of G2/M transition of mitotic cell cycle |
| HPA:0300201 | 0.0401447172992 | 0.75 | RAD50 NBN MRE11 | lung; endothelial cells[>=Low] |
| HP:0031093 | 0.0410470782574 | 0.75 | RAD50 NBN MRE11 | Abnormal breast morphology |
| HP:0000769 | 0.0420203461686 | 0.75 | RAD50 NBN MRE11 | Abnormality of the breast |
| HP:0003220 | 0.0441432413831 | 0.5 | RAD50 NBN | Abnormality of chromosome stability |
| GO:1902749 | 0.0449670283878 | 0.75 | RAD50 NBN MRE11 | regulation of cell cycle G2/M phase transition |
| HP:0000008 | 0.0467645338244 | 0.75 | RAD50 NBN MRE11 | Abnormal morphology of female internal genitalia |
| CORUM:7103 | 0.049938562206 | 0.25 | NBN | NBS1-VRK1 complex |
| CORUM:2723 | 0.049938562206 | 0.25 | NBN | ATM-NBN complex |
| CORUM:2776 | 0.049938562206 | 0.25 | RAD50 | RAD50-BRCA1 complex |
| CORUM:7104 | 0.049938562206 | 0.25 | NBN | NBS1-RNF8-VRK1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD50 | NBN | 0.951 | 0.522 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| NBN | CFAP161 | 0.925 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MRE11 | RAD50 | 0.872 | 0.796 | bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM |
| RAD50 | CFAP161 | 0.865 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| MRE11 | NBN | 0.844 | 0.486 | bioplex_WMM bioplex3_WMM WMM_only |
| MRE11 | CFAP161 | 0.502 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes