hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11291.1
Complex Portal: CPX-22523
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | 5 | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | 5 | UniProt NCBI |
| MAPK1 | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | 5 | UniProt NCBI |
| PTPRR | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) | 5 | UniProt NCBI |
| IRGC | Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) | 4 | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | 5 | UniProt NCBI |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 2.47215416054e-07 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | RSK activation |
| REAC:R-HSA-199920 | 2.47215416054e-07 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | CREB phosphorylation |
| REAC:R-HSA-881907 | 3.94996643825e-06 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-198753 | 9.37394499108e-06 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | ERK/MAPK targets |
| WP:WP437 | 9.57931839251e-06 | 0.666666666667 | RPS6KA3 PTPRR RPS6KA1 RPS6KA2 | EGF EGFR signaling pathway |
| REAC:R-HSA-442742 | 1.08523688914e-05 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| WP:WP4877 | 1.11514262748e-05 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Host pathogen interaction of human coronaviruses MAPK signaling |
| GO:0004711 | 1.92180881975e-05 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | ribosomal protein S6 kinase activity |
| REAC:R-HSA-450282 | 2.85755298292e-05 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04720 | 4.89749392973e-05 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Long-term potentiation |
| KEGG:04010 | 5.63999263147e-05 | 0.666666666667 | RPS6KA3 PTPRR RPS6KA1 RPS6KA2 | MAPK signaling pathway |
| REAC:R-HSA-437239 | 0.000106578184795 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Recycling pathway of L1 |
| REAC:R-HSA-198725 | 0.000173933056475 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Nuclear Events (kinase and transcription factor activation) |
| KEGG:04914 | 0.000174105219358 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-450294 | 0.000194320923954 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.000264877822759 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Interleukin-17 signaling |
| WP:WP477 | 0.000288581380312 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Cytoplasmic ribosomal proteins |
| KEGG:04931 | 0.000298275635298 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Insulin resistance |
| KEGG:04722 | 0.000317011982633 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Neurotrophin signaling pathway |
| WP:WP4321 | 0.000330549913733 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Thermogenesis |
| REAC:R-HSA-438064 | 0.00035066958474 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Post NMDA receptor activation events |
| KEGG:04114 | 0.000356793103324 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Oocyte meiosis |
| KEGG:05135 | 0.000482933906752 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Yersinia infection |
| REAC:R-HSA-442755 | 0.000573821817121 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-168142 | 0.000618329565809 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.000618329565809 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.000618329565809 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 5 (TLR5) Cascade |
| WP:WP3915 | 0.000651957730868 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-975138 | 0.000665071217307 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.000689296551176 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.000689296551176 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-168138 | 0.000792051133325 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00084703415394 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.00090449234483 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00090449234483 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 0.000964479133971 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.000964479133971 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-181438 | 0.00102704788141 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00102704788141 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-2559582 | 0.00102704788141 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-187037 | 0.00102704788141 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Signaling by NTRK1 (TRKA) |
| KEGG:04150 | 0.00103019356944 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | mTOR signaling pathway |
| REAC:R-HSA-373760 | 0.00119511538043 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | L1CAM interactions |
| WP:WP481 | 0.00128798643756 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Insulin signaling |
| KEGG:05207 | 0.00137564197069 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-166520 | 0.00167064168535 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Signaling by NTRKs |
| REAC:R-HSA-166016 | 0.00209955523641 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-416476 | 0.00253713376791 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | G alpha (q) signalling events |
| KEGG:04714 | 0.00272913719926 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Thermogenesis |
| REAC:R-HSA-168898 | 0.00323172543915 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll-like Receptor Cascades |
| REAC:R-HSA-112314 | 0.00445044283113 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2559583 | 0.00604240808777 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Cellular Senescence |
| WP:WP4566 | 0.00820373460581 | 0.333333333333 | RPS6KA2 RPS6KA1 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-112315 | 0.0094130843296 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Transmission across Chemical Synapses |
| WP:WP304 | 0.0127325196108 | 0.333333333333 | RPS6KA3 RPS6KA1 | Kit receptor signaling pathway |
| WP:WP5353 | 0.0268597929621 | 0.333333333333 | RPS6KA3 RPS6KA1 | A network map of Macrophage stimulating protein MSP signaling |
| REAC:R-HSA-112316 | 0.0294801014222 | 0.5 | RPS6KA2 RPS6KA1 RPS6KA3 | Neuronal System |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPS6KA3 | RPS6KA2 | 0.999 |
mutually_exclusive (P28482)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RPS6KA3 | RPS6KA1 | 0.998 | 0.154 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MAPK1 | RPS6KA3 | 0.996 | 0.164 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPS6KA1 | RPS6KA2 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| MAPK1 | PTPRR | 0.977 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK1 | RPS6KA1 | 0.975 | 0.124 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction | |
| MAPK1 | RPS6KA2 | 0.948 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PHKG1 | RPS6KA1 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| IRGC | RPS6KA1 | 0.861 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| IRGC | RPS6KA2 | 0.827 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| IRGC | RPS6KA3 | 0.215 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| PHKG1 | RPS6KA2 | 0.078 | bioplex3_WMM WMM_only | ||
| PHKG1 | RPS6KA3 | 0.076 | bioplex3_WMM WMM_only | ||
| PHKG1 | MAPK1 | 0.04 | bioplex3_WMM WMM_only | ||
| MAPK1 | IRGC | 0.019 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes