hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11313.1
Complex Portal: CPX-20036
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ESRRB | Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2) | 5 | UniProt NCBI |
| PPARGC1B | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | 5 | UniProt NCBI |
| ESRRG | Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) | 5 | UniProt NCBI |
| ESRRA | Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) | 5 | UniProt NCBI |
| PROX1 | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-383280 | 0.00507136546841 | 0.5 | ESRRB ESRRG | Nuclear Receptor transcription pathway |
| GO:0050682 | 0.00842684400117 | 0.5 | PPARGC1B ESRRG | AF-2 domain binding |
| GO:0030518 | 0.0496619752722 | 0.75 | ESRRG ESRRB PPARGC1B | intracellular steroid hormone receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ESRRB | ESRRA | 0.992 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM hein () | |
| ESRRB | ESRRG | 0.987 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPARGC1B | ESRRG | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ESRRA | ESRRG | 0.982 | 0.144 |
mutually_exclusive (O95718)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| PROX1 | ESRRG | 0.923 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PPARGC1B | ESRRA | 0.415 | bioplex3_WMM WMM_only | ||
| ESRRB | PPARGC1B | 0.415 | bioplex3_WMM WMM_only | ||
| PROX1 | PPARGC1B | 0.25 | bioplex3_WMM WMM_only | ||
| PROX1 | ESRRB | 0.113 | bioplex3_WMM WMM_only | ||
| PROX1 | ESRRA | 0.095 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ESRRB | huMAP3_02597.1 huMAP3_11313.1 |
| PPARGC1B | huMAP3_02597.1 huMAP3_11313.1 |
| ESRRG | huMAP3_02597.1 huMAP3_11313.1 |
| ESRRA | huMAP3_02597.1 huMAP3_11313.1 huMAP3_11700.1 |
| PROX1 | huMAP3_01415.1 huMAP3_04075.1 huMAP3_10559.1 huMAP3_11313.1 huMAP3_13336.1 huMAP3_13456.1 huMAP3_13827.1 |