hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11314.1
Complex Portal: CPX-14453
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C22orf39 | Synaptic plasticity regulator PANTS (Plasticity-associated neural transcript short) | 5 | UniProt NCBI |
| RWDD2A | RWD domain-containing protein 2A | 2 | UniProt NCBI |
| CASP2 | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | 5 | UniProt NCBI |
| ATG7 | Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein) | 5 | UniProt NCBI |
| ATG10 | Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4863 | 0.00089796435942 | 0.4 | ATG7 ATG10 | Host pathogen interaction of human coronaviruses autophagy |
| WP:WP2509 | 0.00135500760343 | 0.4 | ATG7 ATG10 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 0.00196978543336 | 0.4 | ATG7 ATG10 | Autophagy - other |
| WP:WP4577 | 0.00456408083355 | 0.4 | ATG7 ATG10 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| WP:WP5205 | 0.0132783799217 | 0.4 | ATG7 ATG10 | Clock controlled autophagy in bone metabolism |
| CORUM:129 | 0.0498708842806 | 0.2 | CASP2 | PIDDsome complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATG7 | RWDD2A | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ATG7 | C22orf39 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ATG7 | ATG10 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ATG7 | CASP2 | 0.906 | 0.04 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CASP2 | C22orf39 | 0.043 | bioplex3_WMM WMM_only |
Related Complexes