hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11315.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CUL7 | Cullin-7 (CUL-7) | 5 | UniProt NCBI |
| MRI1 | Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) | 5 | UniProt NCBI |
| UBE2F | NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F) | 5 | UniProt NCBI |
| CUBN | Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) | 5 | UniProt NCBI |
| ZNF841 | Zinc finger protein 841 | 3 | UniProt NCBI |
| TP53 | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | 5 | UniProt NCBI |
| HNF4A | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | 5 | UniProt NCBI |
| CUL9 | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6577 | 3.43434208394e-07 | 0.375 | CUL7 TP53 CUL9 | 3M complex |
| REAC:R-HSA-8951664 | 0.0405199292649 | 0.375 | CUL7 UBE2F CUL9 | Neddylation |
| WP:WP1403 | 0.0430766937311 | 0.25 | HNF4A TP53 | AMP activated protein kinase signaling |
| CORUM:2681 | 0.0499436884912 | 0.125 | TP53 | p53 homotetramer complex |
| CORUM:5811 | 0.0499436884912 | 0.125 | TP53 | p53-BCL2 complex |
| CORUM:6474 | 0.0499436884912 | 0.125 | CUBN | Cubam complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CUL7 | CUL9 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TP53 | CUL9 | 0.997 | 0.658421901077 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CUL7 | TP53 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF841 | CUL9 | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2F | CUL9 | 0.98 | 0.066 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| MRI1 | CUL9 | 0.965 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| CUL9 | CUBN | 0.922 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TP53 | HNF4A | 0.839 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBE2F | CUBN | 0.415 | bioplex3_WMM WMM_only | |
| UBE2F | ZNF841 | 0.415 | bioplex3_WMM WMM_only | |
| ZNF841 | CUBN | 0.415 | bioplex3_WMM WMM_only | |
| CUL7 | MRI1 | 0.168 | bioplex3_WMM WMM_only | |
| CUL7 | UBE2F | 0.078 | bioplex3_WMM WMM_only | |
| CUL7 | CUBN | 0.078 | bioplex3_WMM WMM_only | |
| CUL7 | ZNF841 | 0.078 | bioplex3_WMM WMM_only | |
| UBE2F | TP53 | 0.076 | 0.57310232303 | bioplex3_WMM WMM_only |
| TP53 | CUBN | 0.076 | 0.241231788079 | bioplex3_WMM WMM_only |
| ZNF841 | TP53 | 0.076 | bioplex3_WMM WMM_only | |
| MRI1 | UBE2F | 0.03 | 0.052 | bioplex3_WMM WMM_only |
| MRI1 | CUBN | 0.03 | 0.024 | bioplex3_WMM WMM_only |
| MRI1 | ZNF841 | 0.03 | bioplex3_WMM WMM_only | |
| MRI1 | TP53 | 0.007 | 0.600598238132 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes