hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11318.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARRB1 | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) | 5 | UniProt NCBI |
| PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4) | 5 | UniProt NCBI |
| ARRB2 | Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) | 5 | UniProt NCBI |
| WDR70 | WD repeat-containing protein 70 | 3 | UniProt NCBI |
| SAG | S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) | 5 | UniProt NCBI |
| BRPF1 | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5635838 | 0.0011839189519 | 0.4 | ARRB2 ARRB1 | Activation of SMO |
| WP:WP4941 | 0.00123199381981 | 0.4 | ARRB2 ARRB1 | GPR143 in melanocytes and retinal pigment epithelium cells |
| WP:WP4871 | 0.00290547066497 | 0.4 | ARRB2 ARRB1 | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP4249 | 0.00389862536801 | 0.4 | ARRB2 ARRB1 | Hedgehog signaling pathway |
| REAC:R-HSA-2122948 | 0.00418294558639 | 0.4 | ARRB2 ARRB1 | Activated NOTCH1 Transmits Signal to the Nucleus |
| KEGG:04929 | 0.00447375439216 | 0.4 | ARRB2 ARRB1 | GnRH secretion |
| KEGG:04340 | 0.00447375439216 | 0.4 | ARRB2 ARRB1 | Hedgehog signaling pathway |
| REAC:R-HSA-456926 | 0.00531742996423 | 0.4 | ARRB2 ARRB1 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-6802948 | 0.0065872694687 | 0.4 | ARRB2 ARRB1 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5674135 | 0.00849065158197 | 0.4 | ARRB2 ARRB1 | MAP2K and MAPK activation |
| REAC:R-HSA-9656223 | 0.00900400267976 | 0.4 | ARRB2 ARRB1 | Signaling by RAF1 mutants |
| KEGG:05032 | 0.0102617382696 | 0.4 | ARRB2 ARRB1 | Morphine addiction |
| REAC:R-HSA-6802946 | 0.0106339701454 | 0.4 | ARRB2 ARRB1 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 0.0106339701454 | 0.4 | ARRB2 ARRB1 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.0106339701454 | 0.4 | ARRB2 ARRB1 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 0.0106339701454 | 0.4 | ARRB2 ARRB1 | Signaling by RAS mutants |
| WP:WP5094 | 0.0128896073912 | 0.4 | ARRB2 ARRB1 | Orexin receptor pathway |
| KEGG:04740 | 0.0149314441262 | 0.4 | ARRB2 ARRB1 | Olfactory transduction |
| KEGG:04928 | 0.0152980219787 | 0.4 | ARRB2 ARRB1 | Parathyroid hormone synthesis, secretion and action |
| WP:WP2355 | 0.0161598479529 | 0.4 | ARRB2 ARRB1 | Corticotropin releasing hormone signaling pathway |
| REAC:R-HSA-6802952 | 0.0232374901507 | 0.4 | ARRB2 ARRB1 | Signaling by BRAF and RAF1 fusions |
| REAC:R-HSA-1980143 | 0.0258071378099 | 0.4 | ARRB2 ARRB1 | Signaling by NOTCH1 |
| KEGG:04926 | 0.0258857078716 | 0.4 | ARRB2 ARRB1 | Relaxin signaling pathway |
| KEGG:04728 | 0.0263659307172 | 0.4 | ARRB2 ARRB1 | Dopaminergic synapse |
| GO:0031701 | 0.0280843539964 | 0.4 | ARRB2 ARRB1 | angiotensin receptor binding |
| WP:WP4659 | 0.0316649111647 | 0.4 | ARRB2 ARRB1 | Gastrin signaling pathway |
| WP:WP536 | 0.0360146352745 | 0.4 | ARRB2 ARRB1 | Calcium regulation in cardiac cells |
| REAC:R-HSA-6802957 | 0.0374197925333 | 0.4 | ARRB2 ARRB1 | Oncogenic MAPK signaling |
| WP:WP3929 | 0.0420114386662 | 0.4 | ARRB2 ARRB1 | Chemokine signaling pathway |
| KEGG:04062 | 0.0427854405203 | 0.4 | ARRB2 ARRB1 | Chemokine signaling pathway |
| REAC:R-HSA-5632684 | 0.0440242300692 | 0.4 | ARRB2 ARRB1 | Hedgehog 'on' state |
| WP:WP289 | 0.0492060648012 | 0.4 | ARRB2 ARRB1 | Myometrial relaxation and contraction pathways |
| CORUM:1297 | 0.0498708842806 | 0.2 | ARRB2 | MKK4-ARRB2-ASK1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ARRB1 | SAG | 0.999 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARRB2 | ARRB1 | 0.986 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ARRB2 | BRPF1 | 0.975 | 0.113666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| BRPF1 | ARRB1 | 0.968 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WDR70 | PLCD4 | 0.942 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ARRB2 | WDR70 | 0.903 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| BRPF1 | PLCD4 | 0.871 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BRPF1 | WDR70 | 0.37 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| BRPF1 | SAG | 0.303 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| ARRB2 | SAG | 0.213 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
| ARRB1 | WDR70 | 0.164 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes