hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11326.1
Complex Portal: CPX-16972
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RACGAP1 | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | 5 | UniProt NCBI |
| USP8 | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | 5 | UniProt NCBI |
| CD2AP | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | 5 | UniProt NCBI |
| SHCBP1 | SHC SH2 domain-binding protein 1 | 3 | UniProt NCBI |
| SH3D19 | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | 5 | UniProt NCBI |
| KIF23 | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | 5 | UniProt NCBI |
| ASIC5 | Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Human intestine Na(+) channel) (HINaC) | 4 | UniProt NCBI |
| ZNF563 | Zinc finger protein 563 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7440 | 2.39226645298e-05 | 0.25 | RACGAP1 KIF23 | KIF23-RACGAP1 complex |
| CORUM:929 | 5.83116661483e-05 | 0.375 | RACGAP1 SHCBP1 KIF23 | CEN complex |
| CORUM:7439 | 7.17483486175e-05 | 0.25 | RACGAP1 KIF23 | ECT2-KIF23-RACGAP1 complex |
| HP:0025035 | 0.000226027933833 | 0.25 | RACGAP1 KIF23 | Abnormal proerythroblast morphology |
| HP:0033212 | 0.000677898190386 | 0.25 | RACGAP1 KIF23 | Abnormal total iron binding capacity |
| HP:0025196 | 0.000677898190386 | 0.25 | RACGAP1 KIF23 | Increased total iron binding capacity |
| WP:WP5199 | 0.00157457895347 | 0.25 | RACGAP1 KIF23 | PtdIns 4 5 P2 in cytokinesis pathway |
| HP:0012130 | 0.00474009355523 | 0.25 | RACGAP1 KIF23 | Abnormal erythroid lineage cell morphology |
| HP:0020047 | 0.00474009355523 | 0.25 | RACGAP1 KIF23 | Abnormal myeloid cell morphology |
| HP:0002315 | 0.00792261538488 | 0.5 | KIF23 RACGAP1 USP8 CD2AP | Headache |
| HP:0003452 | 0.00812142628406 | 0.25 | RACGAP1 KIF23 | Increased serum iron |
| HP:0011891 | 0.0101490036868 | 0.25 | RACGAP1 KIF23 | Post-partum hemorrhage |
| HP:0040130 | 0.0270195830756 | 0.25 | RACGAP1 KIF23 | Abnormal serum iron concentration |
| HP:0011273 | 0.0306138099712 | 0.25 | RACGAP1 KIF23 | Anisocytosis |
| HP:0002249 | 0.0344311064357 | 0.25 | RACGAP1 KIF23 | Melena |
| HP:0030140 | 0.0384712883781 | 0.25 | RACGAP1 KIF23 | Oral cavity bleeding |
| GO:0097149 | 0.0393180950424 | 0.25 | RACGAP1 KIF23 | centralspindlin complex |
| HP:0011031 | 0.0472195728067 | 0.25 | RACGAP1 KIF23 | Abnormality of iron homeostasis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KIF23 | RACGAP1 | 1.0 | 0.794 |
structurally_consistent (Q8NEM2)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SHCBP1 | RACGAP1 | 0.999 | 0.146 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM |
| RACGAP1 | USP8 | 0.993 | 0.05 | hein_WMM bioplex3_WMM WMM_only boldt_WMM | |
| SHCBP1 | KIF23 | 0.99 | 0.128 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM |
| SHCBP1 | CD2AP | 0.982 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| CD2AP | KIF23 | 0.978 | 0.249714285714 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| CD2AP | RACGAP1 | 0.976 | 0.168 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| SHCBP1 | ASIC5 | 0.941 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SHCBP1 | USP8 | 0.919 | 0.092 | hein_WMM bioplex3_WMM WMM_only boldt_WMM | |
| SHCBP1 | ZNF563 | 0.905 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SH3D19 | CD2AP | 0.883 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| SH3D19 | SHCBP1 | 0.873 | 0.042 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| SH3D19 | USP8 | 0.816 | 0.12 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KIF23 | USP8 | 0.585 | 0.11 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| CD2AP | USP8 | 0.385 | 0.128 | hein_WMM youn_WMM hein () gupta_WMM fraction | |
| SH3D19 | KIF23 | 0.234 | 0.074 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SH3D19 | RACGAP1 | 0.045 | 0.250526315789 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes